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Cytochalasins: Structure-activity relationships
Phytochemistry, 1990Abstract Seven cytochalasins, 17- O -acetylcytochalasin A and two derivatives of cytochalasin B were assayed for Pseudomonas syringae , Bacillus megaterium , and for Geotrichum candidum . Their ability to inhibit the growth of tomato seedlings and their toxicity to brine shrimp (% larvae mortality were also investigated.
Bottalico A +4 more
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Cytochalasin binding to macrophages
Cellular Immunology, 1978Cytochalasin-sensitive structures are involved in macrophage motility, membrane recognition phenomena and the internalization of phagocytic particles. The purpose of this study was to characterize the binding of cytochalasins to rabbit alveolar macrophages.
J P, Atkinson, C W, Parker
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Effects of Cytochalasins on Lymphocytes: Some Distinctive Features of Cytochalasin-E
Journal of Immunopharmacology, 1984Cytochalasin-E (CE) has specific properties that distinguishes it from other cytochalasin congeners. We have taken advantage of these in investigating the mechanisms operative in the effects of cytochalasins on lymphocyte proliferative responses to phytomitogens.
B K, Mookerjee, C Y, Jung
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Cytochalasin-u and Cytochalasin-v, 2 New Cytochalasins, From Phoma-exigua Var Heteromorpha
1992Two additional cytochalasins were isolated from liquid culture filtrates of Phoma exiqua var. heteromorpha together with some already known cytochalasins. The two new metabolites, named cytochalasin U and V, represent the first natural occurrence of a 25,26-dioxa[16] and 25-oxa[15]cytochalasan, respectively, both bearing a formyl group on the ...
EVIDENTE, ANTONIO +4 more
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Structure of cytochalasins and cytochalasin B binding sites in human erythrocyte membranes
Biochemistry, 1980Twenty cytochalasins were tested for binding to and for inhibition of glucose transport in human erythrocyte membrane. In this membrane three cytochalasin B (CB) binding sites have been identified. All but three of the cytochalasins bind at site II. On the other hand, only nine of them, which are structurally closely related, bind at site I and inhibit
A L, Rampal, H B, Pinkofsky, C Y, Jung
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Cytochalasin B inhibits thyroid secretion
Biochemical and Biophysical Research Communications, 1971The addition in vitro of cytochalasin B at concentrations of 0.5–3.0 μg/ml to prelabeled mouse thyroid glands interferes with release of iodine derived from thyroglobulin and blocks colloid endocytosis. It is suggested that cytoplasmic microfilaments are involved in the secretory process.
J A, Williams, J, Wolff
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Archives of Biochemistry and Biophysics, 1988
The effects on actin self-assembly of 9 common cytochalasins and 9 synthetic analogs have been assayed using fluorescence photobleaching recovery (FPR). The specific assembly activities of cytochalasins determined by this assay are (i) reduction of the fraction of actin molecules incorporated into filaments; (ii) increase of the steady-state diffusion ...
E A, Walling, G A, Krafft, B R, Ware
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The effects on actin self-assembly of 9 common cytochalasins and 9 synthetic analogs have been assayed using fluorescence photobleaching recovery (FPR). The specific assembly activities of cytochalasins determined by this assay are (i) reduction of the fraction of actin molecules incorporated into filaments; (ii) increase of the steady-state diffusion ...
E A, Walling, G A, Krafft, B R, Ware
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Cytochalasin B induces cellular DNA fragmentation
The FASEB Journal, 1990Cellular DNA fragmentation can be induced in many biological instances without plasma membrane damage. The fungal metabolite, cytochalasin B, is capable of modifying numerous cellular functions related to DNA synthesis. In this work it is demonstrated that cytochalasin B is capable of inducing DNA fragmentation in a number of cells
M A, Kolber +2 more
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