Identification of natural cytochalasins as leads for neglected tropical diseases drug discovery [PDF]
PLoS ONE, 2022 Investigating the chemical diversity of natural products from tropical environments is an inspiring approach to developing new drug candidates for neglected tropical diseases (NTDs).
Marilia Valli +6 more
doaj +3 more sources
Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B [PDF]
Molecules, 2014 Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger.
Lene M. Petersen +6 more
doaj +4 more sources
Six Unprecedented Cytochalasin Derivatives from the Potato Endophytic Fungus Xylaria curta E10 and Their Cytotoxicity [PDF]
Pharmaceuticals, 2023 Six previously undescribed cytochalasins, Curtachalasins X1–X6 (1–6), together with six known compounds (7–12) were isolated from the endophytic fungus Xylaria curta E10 harbored in the plant Solanum tuberosum.
Xian Zhang +7 more
doaj +2 more sources
Pentacyclic Cytochalasins and Their Derivatives from the Endophytic Fungus Phomopsis sp. xz-18 [PDF]
Molecules, 2021 Eight new cytochalasins 1–8 and ten known analogs 9–18 were isolated from the endophytic fungus Phomopsis sp. xz-18. The planar structures of the cytochalasins were determined by HR-ESI-MS and NMR analysis.
Guichon Huang +7 more
doaj +2 more sources
Cytochalasins as Modulators of Stem Cell Differentiation [PDF]
CellsRegenerative medicine aims to identify new research strategies for the repair and restoration of tissues damaged by pathological or accidental events. Mesenchymal stem cells (MSCs) play a key role in regenerative medicine approaches due to their specific
Luca Pampanella +6 more
doaj +2 more sources
Discovery of Secondary Metabolites from the Sponge-Derived Fungus Aspergillus templicola [PDF]
Marine DrugsCombining biosynthetic gene cluster analysis with the OSMAC strategy, fractionation of the fermentation extract of Aspergillus templicola from the sponge Agelas sp. led to the isolation of four novel cytochalasins, colachalasins J–M (1–4), a novel cyclic
Kai Li +5 more
doaj +2 more sources
Immunosuppressive Cytochalasins from the Mangrove Endophytic Fungus Phomopsis asparagi DHS-48 [PDF]
Marine Drugs, 2022 Three new cytochalasins, phomoparagins A-C (1–3), along with five known analogs (4–8), were isolated from Phomopsis asparagi DHS-48, a mangrove-derived endophytic fungus.
Zhao Feng +7 more
doaj +2 more sources
Epigenetic Manipulation Induced Production of Immunosuppressive Chromones and Cytochalasins from the Mangrove Endophytic Fungus Phomopsis asparagi DHS-48 [PDF]
Marine Drugs, 2022 A mangrove endophytic fungus Phomopsis asparagi DHS-48 was found to be particularly productive with regard to the accumulation of substantial new compounds in our previous study.
Ting Feng +5 more
doaj +2 more sources
The Cytochalasins and Polyketides from a Mangrove Endophytic Fungus Xylaria arbuscula QYF [PDF]
Marine DrugsTwelve compounds, including four undescribed cytochalasins, xylariachalasins A–D (1–4), four undescribed polyketides (5–8), and four known cytochalasins (9–12), were isolated from the mangrove endophytic fungus Xylaria arbuscula QYF. Their structures and
Qi Tan +10 more
doaj +2 more sources
Unconventional semi-solid cultivation enhances cytochalasins production by the Colombian fungus Xylaria sp. CM-UDEA-H199 [PDF]
BMC BiotechnologyFungal species of the order Xylariales, particularly those from tropical and untapped areas like the Amazon region, denote an intriguing reservoir of biodiversity and chemically varied metabolites.
Daniela Valencia-Revelo +8 more
doaj +2 more sources