Results 31 to 40 of about 1,936 (197)

Phytochemistry and Biological Activities of Endophytic Fungi from the Meliaceae Family

open access: yesMolecules, 2023
Meliaceae plants are found worldwide in tropical or subtropical climates. They are important ethnobotanically as sources of traditional medicine, with 575 species and 51 genera.
Yeni Mulyani   +2 more
doaj   +1 more source

Antiproliferative and Cytotoxic Cytochalasins from Sparticola triseptata Inhibit Actin Polymerization and Aggregation

open access: yesJournal of Fungi, 2022
Laying the groundwork on preliminary structure–activity relationship study relating to the disruptive activity of cytochalasan derivatives on mammalian cell actin cytoskeleton, we furthered our study on the cytochalasans of the Dothideomycetes fungus ...
Katherine Yasmin M. Garcia   +11 more
doaj   +1 more source

In vitro growth inhibitory effects of cytochalasins and derivatives in cancer cells

open access: yes, 2011
The in vitro anticancer activity of eight natural cytochalasins and three hemisynthetic derivatives of cytochalasin B on six cancer cell lines was evaluated. The IC(50) in vitro growth inhibitory concentrations, as determined by an MTT colorimetric assay,
Mathieu V.   +6 more
core   +2 more sources

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

open access: yesAdvanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino   +12 more
wiley   +1 more source

Three Novel Cytochalasins X, Y, and Z from Pseudeurotium zonatum

open access: yes, 2002
Fermentation of Pseudeurotium zonatum led to the isolation of the known cytochalasin G (1) and three new cytochalasins, X, Y, and Z (2-4). These four compounds are the only naturally occurring cytochalasins reported to date that contain an indole ...
Feng, YJ   +3 more
core   +1 more source

Actin cytoskeletal inhibitor 19,20-epoxycytochalasin Q sensitizes yeast cells lacking ERG6 through actin-targeting and secondarily through disruption of lipid homeostasis

open access: yesScientific Reports, 2021
Repetitive uses of antifungals result in a worldwide crisis of drug resistance; therefore, natural fungicides with minimal side-effects are currently sought after.
Kwanrutai Watchaputi   +4 more
doaj   +1 more source

Multilayered Digital Microfluidic Chip for Cell‐Based Assays

open access: yesAdvanced Materials Interfaces, EarlyView.
A multilayered digital microfluidic (mDMF) chip architecture is introduced to improve throughput and robustness in cell‐based assays. By multilayering electrode components and dielectric layers on glass, this design significantly reduces actuation voltage, maintains reliability, and enables expansion of the operational area with minimum current leakage.
Mert Ozden   +2 more
wiley   +1 more source

Interaction between rabbit muscle actin and several chaetoglobosins or cytochalasins

open access: yes, 1979
The mold metabolites chaetoglobosins Ch-A, B, C, E, F, and J exert, as do the cytochalasins CB, CD, CE, and CG, enhancing effects of various strength on the polymerization of rabbit muscle G-actin. The polymers formed differ widely in their viscosity, Ch-
Yoshihira, K.   +5 more
core   +1 more source

High‐Performance Prevascularized SHED‐Laden rGO@Hydrogel Achieves Optimized Diabetic Bone Defect Repair

open access: yesAdvanced Science, EarlyView.
A high‐performance 3D scaffold integrating rGO and SHEDs is developed to overcome impaired healing in diabetic bone defects. By driving extracellular matrix remodeling, rGO creates a pro‐angiogenic niche that significantly accelerates in vitro vascular network formation.
Can Zhang   +12 more
wiley   +1 more source

Three New Cytochalasins Produced by an Endophytic Fungus in the Genus Rhinocladiella

open access: yes, 2016
Three new cytotoxic cytochalasins (1−3) and the previously reported cytochalasin E (4) were isolated from a culture of the endophytic fungus Rhinocladiella sp. using bioassay-guided fractionation. Extensive NMR and HRCIMS experiments identified these new
Melissa M. Wagenaar (2694457)   +3 more
core   +1 more source

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