Cytochalasins from the Ash Endophytic Fungus Nemania diffusa DSM 116299 [PDF]
MoleculesThe secondary metabolome of Nemania diffusa, isolated as an ash endophytic fungus, was analyzed in detail. From its cultures, a previously undescribed cytochalasin 1 was isolated using preparative HPLC, together with six known congeners: 18-dehydroxy ...
Özge Demir +4 more
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Novel inducible nitric oxide synthase-inhibiting cytochalasins from an oyster-derived fungus Westerdykella dispersa Ca4-13: structural insights and molecular docking analysis [PDF]
Botanical StudiesBackground Marine-derived microorganisms are renowned for producing structurally diverse secondary metabolites with notable biological activities, serving as a promising reservoir for pharmaceutical development.
Shu-Jung Huang +6 more
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Harziachalasins A–G, polycyclic-fused cytochalasins from the endophytic fungus Trichoderma harzianum MLJ-4 with HIV latency reversal activity [PDF]
Natural Products and BioprospectingSeven new polycyclic-fused cytochalasins (CYTs), harziachalasins A–G (1–7), together with three known analogues (8–10) were isolated from the solid culture of the endophytic fungus Trichoderma harzianum MLJ-4, which was originally isolated from the ...
Yan-Jiang Zhang +10 more
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Metabolic Blockade-Based Genome Mining of Malbranchea circinata SDU050: Discovery of Diverse Secondary Metabolites [PDF]
Marine DrugsMalbranchea circinata SDU050, a fungus derived from deep-sea sediment, is a prolific producer of diverse secondary metabolites. Genome sequencing revealed the presence of at least 69 biosynthetic gene clusters (BGCs), including 30 encoding type I ...
Hu Yang +7 more
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Chemical structures, biological activities, and biosynthetic analysis of secondary metabolites of the Diatrypaceae family: A comprehensive review [PDF]
MycologyThe family Diatrypaceae is a less well-known group within the order Xylariales (Ascomycota). Initially, the focus on its metabolites was related to the pathogenicity of one of its members, Eutypa lata.
Shi-Jie Kang +4 more
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Neglected Tropical Diseases: A Chemoinformatics Approach for the Use of Biodiversity in Anti-Trypanosomatid Drug Discovery [PDF]
BiomoleculesThe development of new treatments for neglected tropical diseases (NTDs) remains a major challenge in the 21st century. In most cases, the available drugs are obsolete and have limitations in terms of efficacy and safety.
Marilia Valli +5 more
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New polyketides from the liquid culture of Diaporthe breyniae sp. nov. (Diaporthales, Diaporthaceae) [PDF]
MycoKeys, 2022 During the course of a study on the biodiversity of endophytes from Cameroon, a fungal strain was isolated. A multigene phylogenetic inference using five DNA loci revealed that this strain represents an undescribed species of Diaporthe, which is ...
Blondelle Matio Kemkuignou +6 more
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Molecules, 2021 In our continuous search for antibacterial agents against Pseudomonas syringae pv. actinidiae (Psa) from kiwi-associated fungi, two pairs of epimeric cytochalasins, zopfiellasins A–D (1–4), were characterized from the fungus Zopfiella sp.
Jie-Yu Zhang +4 more
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The Journal of Immunology, 1972 Abstract Cytochalasin B (2 to 4 µg/ml) reversibly inhibits the chemotactic response of human and rabbit polymorphonuclear leukocytes to a bacterial chemotactic factor or to the complement derived factor, C5a. At lower concentrations (1 to 0.1 µg/ml or less) Cytochalasin B actually stimulates chemotaxis.
Elmer L Becker +3 more
openaire +2 more sources
Frontiers in Microbiology, 2020 Cryptococcus neoformans is an important human pathogen with limited options for treatments. We have interrogated extracts from fungal fermentations to find Cryptococcus-inhibiting natural products using assays for growth inhibition, differential ...
Bruno Perlatti +6 more
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