Results 1 to 10 of about 271,428 (260)

In-silico assessment of protein-protein electron transfer. a case study: cytochrome c peroxidase--cytochrome c. [PDF]

PLoS Computational Biology, 2013
The fast development of software and hardware is notably helping in closing the gap between macroscopic and microscopic data. Using a novel theoretical strategy combining molecular dynamics simulations, conformational clustering, ab-initio quantum ...
Frank H Wallrapp, Alexander A Voityuk, Victor Guallar   +2 more
doaj   +3 more sources

Cytochrome c peroxidase facilitates the beneficial use of H₂O₂ in prokaryotes. [PDF]

Proc Natl Acad Sci U S A, 2017
Kaya A, Mariotti M, Gladyshev VN.
europepmc   +4 more sources

Structural basis for cytochrome c Y67H mutant to function as a peroxidase.

PLoS ONE, 2014
The catalytic activity of cytochrome c (cyt c) to peroxidize cardiolipin to its oxidized form is required for the release of pro-apoptotic factors from mitochondria, and for execution of the subsequent apoptotic steps.
Wenxian Lan, Zhonghua Wang, Zhongzheng Yang, Tianlei Ying, Xu Zhang, Xiangshi Tan, Maili Liu, Chunyang Cao, Zhong-Xian Huang   +8 more
doaj   +3 more sources

Enhancing Mn(II)-Binding and Manganese Peroxidase Activity in a Designed Cytochrome c Peroxidase through Fine-Tuning Secondary-Sphere Interactions. [PDF]

Biochemistry, 2016
Hosseinzadeh P, Mirts EN, Pfister TD, Gao YG, Mayne C, Robinson H, Tajkhorshid E, Lu Y.   +7 more
europepmc   +4 more sources

The effect of cardiolipin side chain composition on cytochrome c protein conformation and peroxidase activity

Physiological Reports, 2021
Skeletal muscle, a highly active tissue, makes up 40% of the total body weight. This tissue relies on mitochondria for ATP production, calcium homeostasis, and programed cell death.
Jennifer A. Wilkinson, Sebastian Silvera, Paul J. LeBlanc   +2 more
doaj   +2 more sources

Cytochrome c-peroxidase modulates ROS homeostasis to regulate the sexual mating of Sporisorium scitamineum [PDF]

Microbiology Spectrum, 2023
Sugarcane smut, caused by the basidiomycetous fungus Sporisorium scitamineum, is a global fungal disease resulting in substantial economic losses. Our previous research has highlighted the significant role of reactive oxide species (ROS) in the sexual ...
Enping Cai, Huan Jia, Ruqing Feng, Wenqiang Zheng, Lei Li, Li Zhang, Zide Jiang, Changqing Chang   +7 more
doaj   +2 more sources

Multiple Mutations in the Non-Ordered Red Ω-Loop Enhance the Membrane-Permeabilizing and Peroxidase-like Activity of Cytochrome c

Biomolecules, 2022
A key event in the cytochrome c-dependent apoptotic pathway is the permeabilization of the outer mitochondrial membrane, resulting in the release of various apoptogenic factors, including cytochrome c, into the cytosol.
Rita V. Chertkova, Alexander M. Firsov, Nadezda A. Brazhe, Evelina I. Nikelshparg, Zhanna V. Bochkova, Tatyana V. Bryantseva, Marina A. Semenova, Adil A. Baizhumanov, Elena A. Kotova, Mikhail P. Kirpichnikov, Georgy V. Maksimov, Yuriy N. Antonenko, Dmitry A. Dolgikh   +12 more
doaj   +2 more sources

How Does Replacement of the Axial Histidine Ligand in Cytochrome <i>c</i> Peroxidase by N_δ-Methyl Histidine Affect Its Properties and Functions? A Computational Study. [PDF]

Int J Mol Sci, 2020
Heme peroxidases have important functions in nature related to the detoxification of H2O2. They generally undergo a catalytic cycle where, in the first stage, the iron(III)–heme–H2O2 complex is converted into an iron(IV)–oxo–heme cation radical species ...
Lee CWZ, Mubarak MQE, Green AP, de Visser SP.   +3 more
europepmc   +2 more sources

Evolutionary Approaches to Study Cytochrome c Peroxidase

CHIMIA, 2001
Directed molecular evolution of enzymes and proteins has emerged as an extremely powerful method to create proteins with novel properties, both for practical applications as well as for mechanistic studies.
André Iffland, Petra Tafelmeyer, Susanne Gendreizig, Kai Johnsson   +3 more
doaj   +5 more sources

The response of glutathione oxidase and cytochrome c to exercise training and sodium selenite in the heart tissue of male rats [PDF]

Biochemistry and Biophysics Reports
Introduction: Exercise training combined with supplements may be effective in enhancing antioxidant defense and mitochondrial function. Therefore, this study aimed to determine the response of glutathione peroxidase and cytochrome c to forced resistance ...
Farah Nameni, Fatemeh Elikaei
doaj   +2 more sources