Results 1 to 10 of about 21,140,305 (164)
Inhibitors of cytochrome c biogenesis pathways [PDF]
mBioThe unique composition of bacterial electron transport chains (ETCs), distinct from the human mitochondrial ETC, presents opportunities for selective antibacterial targeting.
Deanna L. Mendez +8 more
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Release of Cytochrome C from Bax Pores at the Mitochondrial Membrane
Scientific Reports, 2017 How cytochrome C is released from the mitochondria to the cytosol via Bax oligomeric pores, a process which is required for apoptosis, is still a mystery.
Mingzhen Zhang +3 more
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Sublethal Cytochrome-c release generates drug-tolerant persister cells
Cell, 2022 SUMMARY: Drug-tolerant persister cells (persisters) evade apoptosis upon targeted and conventional cancer therapies and represent a major non-genetic barrier to effective cancer treatment. Here we show that cells that survive treatment with pro-apoptotic
H. Kalkavan +7 more
semanticscholar +1 more source
Interspecies Variation in the Functional Consequences of Mutation of Cytochrome c. [PDF]
PLoS ONE, 2015 The naturally occurring human cytochrome c variant (G41S) is associated with a mild autosomal dominant thrombocytopenia (Thrombocytopenia Cargeeg) caused by dysregulation of platelet production.
Tracy M Josephs +4 more
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Cytochrome c Negatively Regulates NLRP3 Inflammasomes. [PDF]
PLoS ONE, 2016 The release of cytochrome c from the inner mitochondrial membrane, where it is anchored by caridolipin, triggers the formation of the Apaf-1 apoptosome. Cardiolipin also interacts with NLRP3 recruiting NLRP3 to mitochondria and facilitating inflammasome ...
Chong-Shan Shi, John H Kehrl
doaj +1 more source
Cytochrome-C Oxidase Deficiency
Definitions, 2020 The severity of cytochrome c oxidase deficiency varies widely among affected individuals, even among those in the same family. People who are mildly affected tend to have muscle weakness (myopathy) and poor muscle tone (hypotonia) with no other related ...
M. Brischigliaro, M. Zeviani
semanticscholar +2 more sources
New insight into the mechanism of mitochondrial cytochrome c function. [PDF]
PLoS ONE, 2017 We investigate functional role of the P76GTKMIFA83 fragment of the primary structure of cytochrome c. Based on the data obtained by the analysis of informational structure (ANIS), we propose a model of functioning of cytochrome c. According to this model,
Rita V Chertkova +9 more
doaj +1 more source
Lysine-PEGylated Cytochrome C with Enhanced Shelf-Life Stability
Biosensors, 2022 Cytochrome c (Cyt-c), a small mitochondrial electron transport heme protein, has been employed in bioelectrochemical and therapeutic applications. However, its potential as both a biosensor and anticancer drug is significantly impaired due to poor long ...
João H. P. M. Santos +6 more
doaj +1 more source
In-silico assessment of protein-protein electron transfer. a case study: cytochrome c peroxidase--cytochrome c. [PDF]
PLoS Computational Biology, 2013 The fast development of software and hardware is notably helping in closing the gap between macroscopic and microscopic data. Using a novel theoretical strategy combining molecular dynamics simulations, conformational clustering, ab-initio quantum ...
Frank H Wallrapp +2 more
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Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase
Cells, 2021 Cytochrome c oxidase (COX), the rate-limiting enzyme of mitochondrial respiration, is regulated by various mechanisms. Its regulation by ATP (adenosine triphosphate) appears of particular importance, since it evolved early during evolution and is still ...
Rabia Ramzan +2 more
doaj +1 more source