Results 1 to 10 of about 649,169 (309)

Import of cytochrome c into mitochondria [PDF]

European Journal of Biochemistry, 1987
The import of cytochrome c into mitochondria can be resolved into a number of discrete steps. Here we report on the covalent attachment of heme to apocytochrome c by the enzyme cytochrome c heme lyase in mitochondria from Neurospora crassa. A new method
Basile G., Burnette W. N., Chance B., Dumont M. E., Ernst V., Estabrook R. W., Freitag H., Gasser S. M., Hackenbrock C. R., Hay R., Heller J., Hennig B., Hennig B., Hennig B., Kanarek L., Korb H., Laemmli U. K., Lederer F., Matner R. R., Matsuura S., Means G. E., Mihara K., Nicholson D. W., Nozaki M., Pelham H. R. B., Rietveld A., Rietveld A., Rietveld A., Rietveld A., Scarpulla R. C., Schmidt B., Sherman F., Stewart J. W., Taniuchi H., Taniuchi H., Towbin H., Veloso D., Visco C., Yuan P.-M., Zimmermann R., Zimmermann R., Zimmermann R., Zitomer R. S.   +42 more
core   +3 more sources

Structural Insights into Mechanisms Underlying Mitochondrial and Bacterial Cytochrome c Synthases [PDF]

Biomolecules
Mitochondrial holocytochrome c synthase (HCCS) is an essential protein in assembling cytochrome c (cyt c) of the electron transport system. HCCS binds heme and covalently attaches the two vinyls of heme to two cysteine thiols of the cyt c CXXCH motif ...
Pema L. Childs, Ethan P. Lowder, Deanna L. Mendez, Shalon E. Babbitt, Amidala Martinie, Jonathan Q. Huynh, Robert G. Kranz   +6 more
doaj   +2 more sources

Cytochrome c Negatively Regulates NLRP3 Inflammasomes. [PDF]

PLoS ONE, 2016
The release of cytochrome c from the inner mitochondrial membrane, where it is anchored by caridolipin, triggers the formation of the Apaf-1 apoptosome. Cardiolipin also interacts with NLRP3 recruiting NLRP3 to mitochondria and facilitating inflammasome ...
Chong-Shan Shi, John H Kehrl
doaj   +1 more source

Crystallographic studies of cytochrome c and cytochrome c oxidase [PDF]

The Journal of Biochemistry, 2021
I started on crystallographic studies of cytochrome c (Cyt.c) in the later 1960s at Institute for Protein Research, Osaka University. The institute successfully built the structural model of ferro-Cyt.c by the multiple heavy atom replacement method in the early 1970s.
openaire   +2 more sources

Interspecies Variation in the Functional Consequences of Mutation of Cytochrome c. [PDF]

PLoS ONE, 2015
The naturally occurring human cytochrome c variant (G41S) is associated with a mild autosomal dominant thrombocytopenia (Thrombocytopenia Cargeeg) caused by dysregulation of platelet production.
Tracy M Josephs, Moira E Hibbs, Lily Ong, Ian M Morison, Elizabeth C Ledgerwood   +4 more
doaj   +1 more source

New insight into the mechanism of mitochondrial cytochrome c function. [PDF]

PLoS ONE, 2017
We investigate functional role of the P76GTKMIFA83 fragment of the primary structure of cytochrome c. Based on the data obtained by the analysis of informational structure (ANIS), we propose a model of functioning of cytochrome c. According to this model,
Rita V Chertkova, Nadezda A Brazhe, Tatiana V Bryantseva, Alexey N Nekrasov, Dmitry A Dolgikh, Alexander I Yusipovich, Olga Sosnovtseva, Georgy V Maksimov, Andrei B Rubin, Mikhail P Kirpichnikov   +9 more
doaj   +1 more source

Lysine-PEGylated Cytochrome C with Enhanced Shelf-Life Stability

Biosensors, 2022
Cytochrome c (Cyt-c), a small mitochondrial electron transport heme protein, has been employed in bioelectrochemical and therapeutic applications. However, its potential as both a biosensor and anticancer drug is significantly impaired due to poor long ...
João H. P. M. Santos, Valker A. Feitosa, Giovanna P. Meneguetti, Gustavo Carretero, João A. P. Coutinho, Sónia P. M. Ventura, Carlota O. Rangel-Yagui   +6 more
doaj   +1 more source

Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase

Cells, 2021
Cytochrome c oxidase (COX), the rate-limiting enzyme of mitochondrial respiration, is regulated by various mechanisms. Its regulation by ATP (adenosine triphosphate) appears of particular importance, since it evolved early during evolution and is still ...
Rabia Ramzan, Bernhard Kadenbach, Sebastian Vogt   +2 more
doaj   +1 more source

In-silico assessment of protein-protein electron transfer. a case study: cytochrome c peroxidase--cytochrome c. [PDF]

PLoS Computational Biology, 2013
The fast development of software and hardware is notably helping in closing the gap between macroscopic and microscopic data. Using a novel theoretical strategy combining molecular dynamics simulations, conformational clustering, ab-initio quantum ...
Frank H Wallrapp, Alexander A Voityuk, Victor Guallar   +2 more
doaj   +1 more source

Mitochondrial Encephalopathy and Cytochrome C

Pediatric Neurology Briefs, 1997
Benefits from treatment of mitochondrial encephalomyopathy (MEM) with cytochrome C (6.25 mg) and vitamins Bl (25 mg) and B2 (12.5 mg), in daily injections, are reported from Osaka University Medical School and other centers in Japan.
J Gordon Millichap
doaj   +1 more source