Bacterial TANGO2 homologs are heme-trafficking proteins that facilitate biosynthesis of cytochromes c. [PDF]
mBio, 2023 Heme, an essential molecule for virtually all living organisms, acts primarily as a cofactor in a large number of proteins. However, how heme is mobilized from the site of synthesis to the locations where hemoproteins are assembled remains largely ...
Han S, Guo K, Wang W, Tao YJ, Gao H.
europepmc +4 more sources
Like iron in the blood of the people: the requirement for heme trafficking in iron metabolism. [PDF]
Front Pharmacol, 2014 Heme is an iron-containing porphyrin ring that serves as a prosthetic group in proteins that function in diverse metabolic pathways. Heme is also a major source of bioavailable iron in the human diet.
Korolnek T, Hamza I.
europepmc +5 more sources
Analysis of putative heme ligands in the System I bacterial cytochrome <i>c</i> biogenesis heme transporter, CcmCD. [PDF]
Microbiol SpectrHeme is a key co-factor for biologically important proteins that are required for critical cellular functions such as oxygen transport and energy production.
Kreiman AN +5 more
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Inhibitors of cytochrome <i>c</i> biogenesis pathways. [PDF]
mBioThe unique composition of bacterial electron transport chains (ETCs), distinct from the human mitochondrial ETC, presents opportunities for selective antibacterial targeting.
Mendez DL +8 more
europepmc +2 more sources
Notes from the Underground: Heme Homeostasis in C. elegans
Biomolecules, 2023 Heme is an iron-containing tetrapyrrole that plays a critical role in various biological processes, including oxygen transport, electron transport, signal transduction, and catalysis.
Caiyong Chen, Iqbal Hamza
doaj +1 more source
In Campylobacter jejuni, a new type of chaperone receives heme from ferrochelatase
Frontiers in Genetics, 2023 Intracellular heme formation and trafficking are fundamental processes in living organisms. Bacteria and archaea utilize three biogenesis pathways to produce iron protoporphyrin IX (heme b) that diverge after the formation of the common intermediate ...
Jordi Zamarreño Beas +6 more
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mBio, 2023 Heme trafficking is a fundamental biological process, yet its direct study has been hampered due to heme’s tight intracellular regulation, heme cytotoxicity, and the transient nature of trafficking.
Amber L. Grunow +3 more
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Ferrochelatase: Mapping the Intersection of Iron and Porphyrin Metabolism in the Mitochondria
Frontiers in Cell and Developmental Biology, 2022 Porphyrin and iron are ubiquitous and essential for sustaining life in virtually all living organisms. Unlike iron, which exists in many forms, porphyrin macrocycles are mostly functional as metal complexes. The iron-containing porphyrin, heme, serves as
Chibuike David Obi +5 more
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Ferric reductase-related proteins mediate fungal heme acquisition
eLife, 2022 Heme can serve as iron source in many environments, including the iron-poor animal host environment. The fungal pathobiont Candida albicans expresses a family of extracellular CFEM hemophores that capture heme from host proteins and transfer it across ...
Udita Roy +6 more
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Structures of the CcmABCD heme release complex at multiple states
Nature Communications, 2022 Bacterial ABC transporter complex CcmABCD, a part of cytochrome c maturation system, transfers heme from one binding partner (CcmC) to another (CcmE). Here authors describe high resolution cryo-EM structures of CcmABCD in multiple states and propose a ...
Jiao Li +14 more
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