Like iron in the blood of the people: the requirement for heme trafficking in iron metabolism [PDF]
Frontiers in Pharmacology, 2014 Heme is an iron-containing porphyrin ring that serves as a prosthetic group in proteins that function in diverse metabolic pathways. Heme is also a major source of bioavailable iron in the human diet.
Iqbal Hamza, Hamza Iqbal
exaly +4 more sources
Bacterial TANGO2 homologs are heme-trafficking proteins that facilitate biosynthesis of cytochromes c [PDF]
mBio, 2023 Heme, an essential molecule for virtually all living organisms, acts primarily as a cofactor in a large number of proteins. However, how heme is mobilized from the site of synthesis to the locations where hemoproteins are assembled remains largely ...
Sirui Han +4 more
doaj +2 more sources
Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes
Frontiers in Pharmacology, 2014 Heme (iron-protoporphyrin IX) is an essential co-factor involved in multiple biological processes: oxygen transport and storage, electron transfer, drug and steroid metabolism, signal transduction, and micro RNA processing.
Deborah Chiabrando +2 more
exaly +3 more sources
Analysis of putative heme ligands in the System I bacterial cytochrome c biogenesis heme transporter, CcmCD [PDF]
Microbiology SpectrumHeme is a key co-factor for biologically important proteins that are required for critical cellular functions such as oxygen transport and energy production.
Alicia N. Kreiman +5 more
doaj +2 more sources
Inhibitors of cytochrome c biogenesis pathways [PDF]
mBioThe unique composition of bacterial electron transport chains (ETCs), distinct from the human mitochondrial ETC, presents opportunities for selective antibacterial targeting.
Deanna L. Mendez +8 more
doaj +2 more sources
Regulation of intracellular heme trafficking revealed by subcellular reporters [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Xiaojing Yuan +2 more
exaly +2 more sources
Notes from the Underground: Heme Homeostasis in C. elegans
Biomolecules, 2023 Heme is an iron-containing tetrapyrrole that plays a critical role in various biological processes, including oxygen transport, electron transport, signal transduction, and catalysis.
Caiyong Chen, Iqbal Hamza
doaj +1 more source
In Campylobacter jejuni, a new type of chaperone receives heme from ferrochelatase
Frontiers in Genetics, 2023 Intracellular heme formation and trafficking are fundamental processes in living organisms. Bacteria and archaea utilize three biogenesis pathways to produce iron protoporphyrin IX (heme b) that diverge after the formation of the common intermediate ...
Jordi Zamarreño Beas +6 more
doaj +1 more source
mBio, 2023 Heme trafficking is a fundamental biological process, yet its direct study has been hampered due to heme’s tight intracellular regulation, heme cytotoxicity, and the transient nature of trafficking.
Amber L. Grunow +3 more
doaj +1 more source
Ferrochelatase: Mapping the Intersection of Iron and Porphyrin Metabolism in the Mitochondria
Frontiers in Cell and Developmental Biology, 2022 Porphyrin and iron are ubiquitous and essential for sustaining life in virtually all living organisms. Unlike iron, which exists in many forms, porphyrin macrocycles are mostly functional as metal complexes. The iron-containing porphyrin, heme, serves as
Chibuike David Obi +5 more
doaj +1 more source