Bacterial TANGO2 Homologs Are Heme-Trafficking Proteins That Facilitate Biosynthesis of Cytochromes c. [PDF]
MBio, 2023 Heme, an essential molecule for virtually all living organisms, acts primarily as a cofactor in a large number of proteins. However, how heme is mobilized from the site of synthesis to the locations where hemoproteins are assembled remains largely ...
Yizhi Jane Tao, Haichun Gao
exaly +4 more sources
Like Iron in the Blood of the People: The Requirement for Heme Trafficking in Iron Metabolism [PDF]
Frontiers in Pharmacology, 2014 Heme is an iron-containing porphyrin ring that serves as a prosthetic group in proteins that function in diverse metabolic pathways. Heme is also a major source of bioavailable iron in the human diet.
Iqbal Hamza
exaly +4 more sources
Heme in Pathophysiology: A Matter of Scavenging, Metabolism and Trafficking Across Cell Membranes
Frontiers in Pharmacology, 2014 Heme (iron-protoporphyrin IX) is an essential co-factor involved in multiple biological processes: oxygen transport and storage, electron transfer, drug and steroid metabolism, signal transduction, and micro RNA processing.
Veronica Fiorito +2 more
exaly +3 more sources
Pathways of copper import and utilization that support respiration in Bacillus subtilis [PDF]
mBioCopper is an enzyme cofactor that is essential for cellular respiration in most aerobic organisms but can be toxic in excess. Although most copper enzymes are localized within or external to the cell membrane, proper copper loading often relies on copper
Grayson Barnes +4 more
doaj +2 more sources
Regulation of Intracellular Heme Trafficking Revealed by Subcellular Reporters [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Hanna Kwon, Xiaojing Yuan, Emma L. Raven
exaly +2 more sources
Progesterone Receptor Membrane Component 1 (PGRMC1) Regulates Heme Trafficking Through Mitochondria-ER Junctions [PDF]
Journal of Inorganic BiochemistryPiel Iii RB +15 more
exaly +2 more sources
Notes from the Underground: Heme Homeostasis in C. elegans
Biomolecules, 2023 Heme is an iron-containing tetrapyrrole that plays a critical role in various biological processes, including oxygen transport, electron transport, signal transduction, and catalysis.
Caiyong Chen, Iqbal Hamza
doaj +1 more source
In Campylobacter jejuni, a new type of chaperone receives heme from ferrochelatase
Frontiers in Genetics, 2023 Intracellular heme formation and trafficking are fundamental processes in living organisms. Bacteria and archaea utilize three biogenesis pathways to produce iron protoporphyrin IX (heme b) that diverge after the formation of the common intermediate ...
Jordi Zamarreño Beas +6 more
doaj +1 more source
mBio, 2023 Heme trafficking is a fundamental biological process, yet its direct study has been hampered due to heme’s tight intracellular regulation, heme cytotoxicity, and the transient nature of trafficking.
Amber L. Grunow +3 more
doaj +1 more source
Ferrochelatase: Mapping the Intersection of Iron and Porphyrin Metabolism in the Mitochondria
Frontiers in Cell and Developmental Biology, 2022 Porphyrin and iron are ubiquitous and essential for sustaining life in virtually all living organisms. Unlike iron, which exists in many forms, porphyrin macrocycles are mostly functional as metal complexes. The iron-containing porphyrin, heme, serves as
Chibuike David Obi +5 more
doaj +1 more source