Results 41 to 50 of about 213,829 (198)
The Role of the Cytoplasmic Heme-binding Protein (PhuS) of Pseudomonas aeruginosa in Intracellular Heme Trafficking and Iron Homeostasis [PDF]
Journal of Biological Chemistry, 2009 The cytoplasmic heme-binding protein PhuS, encoded within the Fur-regulated Pseudomonas heme utilization (phu) operon, has previously been shown to traffic heme to the iron-regulated heme oxygenase (HO). We further investigate the role of PhuS in heme trafficking to HO on disruption of the phuS and hemO genes in a Pseudomonas aeruginosa siderophore ...
Ajinder P, Kaur +2 more
openaire +2 more sources
Mucosal Immunology, 2022 Heme metabolism is a key regulator of inflammatory responses. Cobalt protoporphyrin IX (CoPP) is a heme analog and mimic that potently activates the NRF2/heme oxygenase-1 (HO-1) pathway, especially in monocytes and macrophages. We investigated the influence of CoPP on inflammatory responses using a murine model of colitis.
Rachel E.M. Schaefer +7 more
openaire +2 more sources
Angewandte Chemie, EarlyView.A meso‐carboxamide‐substituted BODIPY fluorescent probe reports myeloperoxidase (MPO) activity via electrophilic chlorination by MPO‐derived HOCl, generating a highly emissive chlorinated product with a ca. 40 nm bathochromic shift. Applications in quantitative MPO assays, cellular imaging of MPO‐derived HOCl, redox‐dependent discrimination of cancer ...
Siyoung Cho +3 more
wiley +2 more sources
Probing Heme Trafficking Using Genetically Encoded Fluorescent Heme Sensors
, 2021 In this thesis, we describe genetic screens in Baker’s yeast to identify factors that regulate a. steady-state heme availability, b. the dynamics of heme mobilization to different subcellular compartments as it is being synthesized, and c.
Martinez-Guzman, Osiris
core
mBioHeme is a redox-active cofactor for essential processes across all domains of life. Heme’s redox capabilities are responsible for its biological significance but also make it highly cytotoxic, requiring tight intracellular regulation.
Alicia N. Kreiman +3 more
doaj +1 more source
Scientific Reports, 2022 Soluble guanylate cyclase (sGC) requires a heme-group bound in order to produce cGMP, a second messenger involved in memory formation, while heme-free sGC is inactive.
Ellis Nelissen +11 more
doaj +1 more source
Investigating the Connection Between Endogenous Heme Accumulation and COX2 Activity in Cancer Cells
Frontiers in Oncology, 2019 Heme, an iron-containing porphyrin, is fundamental for a variety of functions in cell homeostasis. Nevertheless, recent data indicate that dysregulation of heme metabolism might promote tumorigenesis.
Francesca Destefanis +3 more
doaj +1 more source
Cj1386 Is an Ankyrin-Containing Protein Involved in Heme Trafficking to Catalase in Campylobacter jejuni [PDF]
Journal of Bacteriology, 2012 ABSTRACT Campylobacter jejuni , a microaerophilic bacterium, is the most frequent cause of human bacterial gastroenteritis. C. jejuni is exposed to harmful reactive oxygen species (ROS) produced during its own normal metabolic processes and during infection from the host immune system and from ...
Annika, Flint +2 more
openaire +2 more sources
Frontiers in Physiology, 2022 Throughout mammal erythroid differentiation, erythroblasts undergo enucleation and organelle clearance becoming mature red blood cell. Organelles are cleared by autophagic pathways non-specifically targeting organelles and cytosolic content or by ...
Alice Dussouchaud +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source