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Whole-Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine-Tuned Heme Biosynthesis
Advanced Science, 2023 By exploiting versatile P450 enzymes, whole‐cell biocatalysis can be performed to synthesize valuable compounds in Escherichia coli. However, the insufficient supply of heme limits the whole‐cell P450 biocatalytic activity.
Xinrui Zhao, Guocheng Du, Jingwen Zhou
exaly +4 more sources
Iron Metabolism in the Disorders of Heme Biosynthesis [PDF]
Metabolites, 2022 Given its remarkable property to easily switch between different oxidative states, iron is essential in countless cellular functions which involve redox reactions. At the same time, uncontrolled interactions between iron and its surrounding milieu may be
Andrea Ricci +5 more
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Toxoplasma gondii requires its plant-like heme biosynthesis pathway for infection [PDF]
PLoS Pathogens, 2020 Heme, an iron-containing organic ring, is essential for virtually all living organisms by serving as a prosthetic group in proteins that function in diverse cellular activities ranging from diatomic gas transport and sensing, to mitochondrial respiration,
Melanie Key +2 more
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Microbial Cell Factories, 2023 Background Heme is an iron/porphyrin complex compound, widely used in the health care, food, and pharmaceutical industries. It is more advantageous and attractive to develop microbial cell factories to produce heme by fermentation, with lower production ...
Shaomei Yang +9 more
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Erythropoietin signaling regulates heme biosynthesis [PDF]
eLife, 2017 Heme is required for survival of all cells, and in most eukaryotes, is produced through a series of eight enzymatic reactions. Although heme production is critical for many cellular processes, how it is coupled to cellular differentiation is unknown ...
Jacky Chung +21 more
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Translational Psychiatry, 2023 Relapse is common in remitted patients with major depressive disorder (MDD). Arketamine, an (R)-enantiomer of ketamine, has persistent prophylactic actions in an inflammatory model of depression.
Li Ma +4 more
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Frontiers in Medicine, 2022 ObjectiveThe intraoperative visualization of adult-type diffuse gliomas with 5-aminolevulinic acid (5-ALA) induced fluorescence is widely used in the neurosurgical field.
Mario Mischkulnig +23 more
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Cellular Zinc Deficiency Impairs Heme Biosynthesis in Developing Erythroid Progenitors [PDF]
Nutrients, 2023 Anemia is the most prevalent nutrition-related disorder worldwide. Zinc is an essential trace element for various biological processes in the body, and zinc deficiency has been associated with anemia in humans.
Juyoung Kim, Jaekwon Lee, Moon-Suhn Ryu
semanticscholar +2 more sources
Structural aspects of enzymes involved in prokaryotic Gram-positive heme biosynthesis
Computational and Structural Biotechnology Journal, 2023 The coproporphyrin dependent heme biosynthesis pathway is almost exclusively utilized by Gram-positive bacteria. This fact makes it a worthwhile topic for basic research, since a fundamental understanding of a metabolic pathway is necessary to translate ...
Nikolaus Falb +4 more
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Nature Communications, 2020 Heme biosynthesis depends on iron-sulfur (Fe-S) cluster biogenesis but the molecular connection between these pathways is not fully understood. Here, the authors show that the heme biosynthesis enzyme ALAD contains an Fe-S cluster, disruption of which ...
Gang Liu +6 more
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