Whole‐Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine‐Tuned Heme Biosynthesis [PDF]
Advanced Science, 2023 By exploiting versatile P450 enzymes, whole‐cell biocatalysis can be performed to synthesize valuable compounds in Escherichia coli. However, the insufficient supply of heme limits the whole‐cell P450 biocatalytic activity.
Baodong Hu +7 more
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Iron Metabolism in the Disorders of Heme Biosynthesis [PDF]
Metabolites, 2022 Given its remarkable property to easily switch between different oxidative states, iron is essential in countless cellular functions which involve redox reactions. At the same time, uncontrolled interactions between iron and its surrounding milieu may be
Andrea Ricci +5 more
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Toxoplasma gondii requires its plant-like heme biosynthesis pathway for infection. [PDF]
PLoS Pathogens, 2020 Heme, an iron-containing organic ring, is essential for virtually all living organisms by serving as a prosthetic group in proteins that function in diverse cellular activities ranging from diatomic gas transport and sensing, to mitochondrial respiration,
Amy Bergmann +8 more
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Regulation of heme biosynthesis via the coproporphyrin dependent pathway in bacteria [PDF]
Frontiers in MicrobiologyHeme biosynthesis in the Gram-positive bacteria occurs mostly via a pathway that is distinct from that of eukaryotes and Gram-negative bacteria in the three terminal heme synthesis steps.
Hadia Aftab, Rebecca K. Donegan
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Structural aspects of enzymes involved in prokaryotic Gram-positive heme biosynthesis [PDF]
Computational and Structural Biotechnology Journal, 2023 The coproporphyrin dependent heme biosynthesis pathway is almost exclusively utilized by Gram-positive bacteria. This fact makes it a worthwhile topic for basic research, since a fundamental understanding of a metabolic pathway is necessary to translate ...
Nikolaus Falb +4 more
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Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase [PDF]
Nature Communications, 2020 Heme biosynthesis depends on iron-sulfur (Fe-S) cluster biogenesis but the molecular connection between these pathways is not fully understood. Here, the authors show that the heme biosynthesis enzyme ALAD contains an Fe-S cluster, disruption of which ...
Gang Liu +6 more
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The impact of heme biosynthesis regulation on glioma aggressiveness: Correlations with diagnostic molecular markers [PDF]
Frontiers in Molecular Neuroscience, 2022 BackgroundThe prognosis of diffusely infiltrating glioma patients is dismal but varies greatly between individuals. While characterization of gliomas primarily relied on histopathological features, molecular markers increasingly gained importance and ...
Mario Mischkulnig +21 more
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A role of splenic heme biosynthesis pathway in the persistent prophylactic actions of arketamine in lipopolysaccharide-treated mice [PDF]
Translational Psychiatry, 2023 Relapse is common in remitted patients with major depressive disorder (MDD). Arketamine, an (R)-enantiomer of ketamine, has persistent prophylactic actions in an inflammatory model of depression.
Li Ma +4 more
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Heme Biosynthesis Factors and 5-ALA Induced Fluorescence: Analysis of mRNA and Protein Expression in Fluorescing and Non-fluorescing Gliomas [PDF]
Frontiers in Medicine, 2022 ObjectiveThe intraoperative visualization of adult-type diffuse gliomas with 5-aminolevulinic acid (5-ALA) induced fluorescence is widely used in the neurosurgical field.
Mario Mischkulnig +23 more
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Heme biosynthesis in prokaryotes
Biochimica Et Biophysica Acta - Molecular Cell Research, 2021 The cyclic tetrapyrrole heme is used as a prosthetic group in a broad variety of different proteins in almost all organisms. Often, it is essential for vital biochemical processes such as aerobic and anaerobic respiration as well as photosynthesis. In Nature, heme is made from the common tetrapyrrole precursor 5-aminolevulinic acid, and for a long time
Gunhild Layer
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