Results 11 to 20 of about 44,892 (270)
Heme biosynthesis and its regulation: towards understanding and improvement of heme biosynthesis in filamentous fungi [PDF]
Applied Microbiology and Biotechnology, 2011 Heme biosynthesis in fungal host strains has acquired considerable interest in relation to the production of secreted heme-containing peroxidases. Class II peroxidase enzymes have been suggested as eco-friendly replacements of polluting chemical processes in industry.
Arthur F J Ram +2 more
exaly +7 more sources
Erythropoietin signaling regulates heme biosynthesis [PDF]
eLife, 2017 Heme is required for survival of all cells, and in most eukaryotes, is produced through a series of eight enzymatic reactions. Although heme production is critical for many cellular processes, how it is coupled to cellular differentiation is unknown ...
Jacky Chung +21 more
doaj +7 more sources
Heme Biosynthesis mRNA Expression Signature: Towards a Novel Prognostic Biomarker in Patients with Diffusely Infiltrating Gliomas [PDF]
Cancers, 2021 Diffusely infiltrating gliomas are characterized by a variable clinical course, and thus novel prognostic biomarkers are needed. The heme biosynthesis cycle constitutes a fundamental metabolic pathway and might play a crucial role in glioma biology.
Mario Mischkulnig +2 more
exaly +3 more sources
Heme biosynthesis and the porphyrias [PDF]
Molecular Genetics and Metabolism, 2019 Porphyrias, is a general term for a group of metabolic diseases that are genetic in nature. In each specific porphyria the activity of specific enzymes in the heme biosynthetic pathway is defective and leads to accumulation of pathway intermediates.
Phillips JD.
openaire +3 more sources
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012 Respiration in plants, most animals and many aerobic microbes is dependent on heme A. This is a highly specialized type of heme found as prosthetic group in cytochrome a-containing respiratory oxidases. Heme A differs structurally from heme B (protoheme IX) by the presence of a hydroxyethylfarnesyl group instead of a vinyl side group at the C2 position
Hederstedt, Lars, Hederstedt, Lars,
openaire +3 more sources
Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study [PDF]
Scientific Reports, 2022 Obstructive sleep apnea (OSA) is a common disorder associated with increased risk of cardiovascular disease and mortality. Iron and heme metabolism, implicated in ventilatory control and OSA comorbidities, was associated with OSA phenotypes in recent ...
Heming Wang +26 more
doaj +2 more sources
Microbial Cell Factories, 2023 Background Heme is an iron/porphyrin complex compound, widely used in the health care, food, and pharmaceutical industries. It is more advantageous and attractive to develop microbial cell factories to produce heme by fermentation, with lower production ...
Shaomei Yang +9 more
doaj +2 more sources
Zinc supplementation improves heme biosynthesis in rats exposed to lead
Universa Medicina, 2016 BACKGROUND Lead acetate (Pb) inhibits heme biosynthesis through inhibition of δ-aminolevulinic acid dehydrogenase (δ-ALAD), copro porphyrinogen oxidase, and ferro chelatase. Zinc supplementation increases lead-binding metallothionein proteins.
Budi Santoso +3 more
doaj +2 more sources
SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia [PDF]
Cell Reports, 2022 Takayuki Hoshii +2 more
exaly +2 more sources
Cellular Zinc Deficiency Impairs Heme Biosynthesis in Developing Erythroid Progenitors. [PDF]
Nutrients, 2023 Anemia is the most prevalent nutrition-related disorder worldwide. Zinc is an essential trace element for various biological processes in the body, and zinc deficiency has been associated with anemia in humans.
Kim J, Lee J, Ryu MS.
europepmc +2 more sources