Results 11 to 20 of about 732,679 (273)

Biosynthesis of High‐Active Hemoproteins by the Efficient Heme‐Supply Pichia Pastoris Chassis

Advanced Science, 2023
Microbial synthesis of valuable hemoproteins has become a popular research topic, and Pichia pastoris is a versatile platform for the industrial production of recombinant proteins.
Fei Yu, Xinrui Zhao, Jingwen Zhou, Wei Lu, Jianghua Li, Jian Chen, Guocheng Du   +6 more
doaj   +2 more sources

Heme biosynthesis in prokaryotes.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020
The cyclic tetrapyrrole heme is used as a prosthetic group in a broad variety of different proteins in almost all organisms. Often, it is essential for vital biochemical processes such as aerobic and anaerobic respiration as well as photosynthesis.
G. Layer
semanticscholar   +4 more sources

Regulation of heme biosynthesis via the coproporphyrin dependent pathway in bacteria

Frontiers in Microbiology
Heme biosynthesis in the Gram-positive bacteria occurs mostly via a pathway that is distinct from that of eukaryotes and Gram-negative bacteria in the three terminal heme synthesis steps.
Hadia Aftab, Rebecca K. Donegan
doaj   +2 more sources

Heme biosensor-guided in vivo pathway optimization and directed evolution for efficient biosynthesis of heme

Biotechnology for Biofuels and Bioproducts, 2023
Background Heme has attracted much attention because of its wide applications in medicine and food. The products of genes hemBCDEFY convert 5-aminolevulinic acid to protoporphyrin IX (PPIX; the immediate precursor of heme); protoporphyrin ferrochelatase (
Jian Zhang, Qingbin Li, Qi Wang, Jingyu Zhao, Yuan Zhu, Tianyuan Su, Qingsheng Qi, Qian Wang   +7 more
doaj   +2 more sources

SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia

Cell Reports, 2022
SUMMARY Histone methyltransferase SETD1A is critical for acute myeloid leukemia (AML) cell survival, but the molecular mechanism driving SETD1A gene regulation remains elusive.
Tomoyoshi Soga, Bahityar Rahmutulla, Takayuki Hoshii   +2 more
exaly   +2 more sources

Applications of the Whole-Cell System in the Efficient Biosynthesis of Heme

International Journal of Molecular Sciences, 2023
Heme has a variety of functions, from electronic reactions to binding gases, which makes it useful in medical treatments, dietary supplements, and food processing.
Hongfei Su, Xiao-Lin Chen, Shijing Chen, Ming-Zhang Guo, Hui-Lin Liu   +4 more
semanticscholar   +2 more sources

Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia

Cell
The ubiquitous metabolite heme has diverse enzymatic and signaling functions in most mammalian cells. Through integrated analyses of mouse models, human cell lines, and primary patient samples, we identify de novo heme biosynthesis as a selective ...
Emily Gruber, Lev Kats, Kristin Brown
exaly   +2 more sources

Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity

Cell Metabolism, 2019
Crosstalk between metabolic and survival pathways is critical for cellular homeostasis, but the connectivity between these processes remains poorly defined.
Abigail Xie, Timothy Robert Koves, David Rizzieri   +2 more
exaly   +2 more sources

Heme biosynthesis and the porphyrias [PDF]

Molecular Genetics and Metabolism, 2019
Porphyrias, is a general term for a group of metabolic diseases that are genetic in nature. In each specific porphyria the activity of specific enzymes in the heme biosynthetic pathway is defective and leads to accumulation of pathway intermediates ...
J. Phillips
semanticscholar   +3 more sources

Biosynthesis, acquisition, regulation, and upcycling of heme: recent advances

Critical Reviews in Biotechnology
Heme, an iron-containing tetrapyrrole in hemoproteins, including: hemoglobin, myoglobin, catalase, cytochrome c, and cytochrome P450, plays critical physiological roles in different organisms.
Xinrui Zhao, Guocheng Du, Jingwen Zhou
exaly   +2 more sources