Heme biosynthesis and its regulation: towards understanding and improvement of heme biosynthesis in filamentous fungi [PDF]
Applied Microbiology and Biotechnology, 2011 Heme biosynthesis in fungal host strains has acquired considerable interest in relation to the production of secreted heme-containing peroxidases. Class II peroxidase enzymes have been suggested as eco-friendly replacements of polluting chemical processes in industry.
Arthur Ram +2 more
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Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase [PDF]
Nature Communications, 2020 Heme biosynthesis depends on iron-sulfur (Fe-S) cluster biogenesis but the molecular connection between these pathways is not fully understood. Here, the authors show that the heme biosynthesis enzyme ALAD contains an Fe-S cluster, disruption of which ...
Gang Liu +6 more
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Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study [PDF]
Scientific Reports, 2022 Obstructive sleep apnea (OSA) is a common disorder associated with increased risk of cardiovascular disease and mortality. Iron and heme metabolism, implicated in ventilatory control and OSA comorbidities, was associated with OSA phenotypes in recent ...
Heming Wang +26 more
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Erythropoietin signaling regulates heme biosynthesis [PDF]
eLife, 2017 Heme is required for survival of all cells, and in most eukaryotes, is produced through a series of eight enzymatic reactions. Although heme production is critical for many cellular processes, how it is coupled to cellular differentiation is unknown ...
Jacky Chung +21 more
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Involvement of Small Colony Variant-Related Heme Biosynthesis Genes in Staphylococcus aureus Persister Formation in vitro [PDF]
Frontiers in Microbiology, 2021 Background: Persisters are important reasons for persistent infections, and they can lead to antibiotic treatment failure in patients and consequently chronic infection.
Xuyang Wang +8 more
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Structure and function of enzymes in heme biosynthesis [PDF]
Protein Science, 2010 AbstractTetrapyrroles like hemes, chlorophylls, and cobalamin are complex macrocycles which play essential roles in almost all living organisms. Heme serves as prosthetic group of many proteins involved in fundamental biological processes like respiration, photosynthesis, and the metabolism and transport of oxygen.
Gunhild Layer, Dieter Jahn
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Exploiting Differences in Heme Biosynthesis between Bacterial Species to Screen for Novel Antimicrobials [PDF]
Biomolecules, 2023 John Phillips +2 more
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SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia [PDF]
Cell Reports, 2022 Tomoyoshi Soga +2 more
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Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer?
Acta Biochimica Indonesiana, 2022 Heme is a compound consisting of an iron (Fe) atom bound to a pyrrole ring forming protoporphyrin IX (PPIX). Protoporphyrin combines with a protein-forming hemoprotein compound that plays an essential role in oxygen-binding and transport as well as in ...
Raisa Nauli, Sri Widia A Jusman
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Frontiers in Bioengineering and Biotechnology, 2023 Heme is an important tetrapyrrole compound, and has been widely applied in food and medicine industries. Although microbial production of heme has been developed with metabolic engineering strategies during the past 20 years, the production levels are ...
Yingyu Zhou +24 more
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