Results 21 to 30 of about 44,892 (270)

Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer?

Acta Biochimica Indonesiana, 2022
Heme is a compound consisting of an iron (Fe) atom bound to a pyrrole ring forming protoporphyrin IX (PPIX). Protoporphyrin combines with a protein-forming hemoprotein compound that plays an essential role in oxygen-binding and transport as well as in ...
Raisa Nauli, Sri Widia A Jusman
doaj   +1 more source

Development of a growth-coupled selection platform for directed evolution of heme biosynthetic enzymes in Corynebacterium glutamicum

Frontiers in Bioengineering and Biotechnology, 2023
Heme is an important tetrapyrrole compound, and has been widely applied in food and medicine industries. Although microbial production of heme has been developed with metabolic engineering strategies during the past 20 years, the production levels are ...
Yingyu Zhou, Yingyu Zhou, Jiuzhou Chen, Jiuzhou Chen, Wei Pu, Wei Pu, Ningyun Cai, Ningyun Cai, Bin Che, Bin Che, Jinxing Yang, Jinxing Yang, Mengmeng Wang, Mengmeng Wang, Shasha Zhong, Shasha Zhong, Xingtao Zuo, Xingtao Zuo, Depei Wang, Yu Wang, Yu Wang, Ping Zheng, Ping Zheng, Jibin Sun, Jibin Sun   +24 more
doaj   +1 more source

Herbicides as fungicides: Targeting heme biosynthesis in the maize pathogen Ustilago maydis. [PDF]

Mol Plant Pathol
Pathogens must efficiently acquire nutrients from host tissue to proliferate, and strategies to block pathogen access therefore hold promise for disease control. In this study, we investigated whether heme biosynthesis is an effective target for ablating
Damoo D, Kretschmer M, Lee CWJ, Herrfurth C, Feussner I, Heimel K, Kronstad JW.   +6 more
europepmc   +2 more sources

Fluorescence-based Heme Quantitation in Toxoplasma Gondii

Bio-Protocol, 2021
Toxoplasma gondii is a highly prevalent protozoan pathogen throughout the world. As a eukaryotic intracellular pathogen, Toxoplasma ingests nutrients from host cells to support its intracellular growth. The parasites also encode full or partial metabolic
Amy Bergmann, Zhicheng Dou
doaj   +1 more source

Growth phenotype analysis of heme synthetic enzymes in a halophilic archaeon, Haloferax volcanii. [PDF]

PLoS ONE, 2017
Halophilic euryarchaea lack many of the genes necessary for the protoporphyrin-dependent heme biosynthesis pathway previously identified in animals and plants.
Naoki Kosugi, Takuma Araki, Junpei Fujita, Satoru Tanaka, Taketomo Fujiwara   +4 more
doaj   +1 more source

The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage

Frontiers in Chemistry, 2022
Cytochrome P450 enzymes (P450s) are a superfamily of monooxygenases that utilize a cysteine thiolate–ligated heme moiety to perform a wide range of demanding oxidative transformations.
Anja Greule, Anja Greule, Thierry Izoré, Thierry Izoré, Daniel Machell, Daniel Machell, Daniel Machell, Mathias H. Hansen, Mathias H. Hansen, Mathias H. Hansen, Melanie Schoppet, Melanie Schoppet, James J. De Voss, Louise K. Charkoudian, Ralf B. Schittenhelm, Ralf B. Schittenhelm, Jeffrey R. Harmer, Max J. Cryle, Max J. Cryle, Max J. Cryle   +19 more
doaj   +1 more source

New Insights into the Pivotal Role of Iron/Heme Metabolism in TLR4/NF-κB Signaling-Mediated Inflammatory Responses in Human Monocytes

Cells, 2021
Iron metabolism and heme biosynthesis are essential processes in cells during the energy cycle. Alteration in these processes could create an inflammatory condition, which results in tumorigenesis.
Dong Young Kang, Nipin Sp, Eun Seong Jo, Jin-Moo Lee, Kyoung-Jin Jang   +4 more
doaj   +1 more source

Plasmodium heme biosynthesis: To be or not to be essential? [PDF]

PLoS Pathogens, 2017
Daniel E Goldberg, Paul A Sigala
exaly   +2 more sources

Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α [PDF]

, 2005
Inducible hepatic porphyrias are inherited genetic disorders of enzymes of heme biosynthesis. The main clinical manifestations are acute attacks of neuropsychiatric symptoms frequently precipitated by drugs, hormones, or fasting, associated with ...
Lin, J., Handschin, Christoph, Rhee, James, Peyer, Anne-Kathrin, Meyer, Urs A, Spiegelman, Bruce M., Handschin, C., Spiegelman, Bruce M, Meyer, U. A., Lin, Jiandie, Rhee, J., Wu, P. -H., Peyer, A. -K., Chin, Sherry, Meyer, Urs A., Spiegelman, B. M., Chin, S., Wu, Pei-Hsuan   +17 more
core   +1 more source

Structure and Function of the Bacterial Heterodimeric ABC Transporter CydDC: Stimulation of the ATPase Activity by Thiol and Heme Compounds [PDF]

, 2014
In Escherichia coli, the biogenesis of both cytochrome bd-type quinol oxidases and periplasmic cytochromes requires the ABC- type cysteine/glutathione (GSH) transporter, CydDC.
Xie, H, Poole, Robert K,, Nyathi, Yvonne, Booth, WI, Nyathi, Y, Bullough, PA, Booth, Wesley I., Xie, Hua, Postis, Vincent; id_orcid, Poole, R. K., Tzokov, Svetomir B., Booth, W.I., Postis, Vincent, Yamashita, M., Booth, W. I., Baldwin, SA, Tzokov, S, Baldwin, Stephen A., Bullough, Per A, Postis, V, Postis, V., Yamashita, Masao, Yamashita, M, Bullough, Per A., Tzokov, Svetomir, Shepherd, M., Poole, RK, Bullough, P.A., Xie, Hao, Bullough, P. A., Poole, Robert K, Poole, R.K., Booth, Wesley I, Nyathi, Y., Tzokov, S. B., Xie, H., Baldwin, Stephen A, Baldwin, S.A., Tzokov, SB, Baldwin, S. A., Shepherd, Mark, Tzokov, S.B., Shepherd, M   +42 more
core   +1 more source