Results 21 to 30 of about 732,679 (273)
mBio, 2023 Heme, an essential molecule for virtually all living organisms, acts primarily as a cofactor in a large number of proteins. However, how heme is mobilized from the site of synthesis to the locations where hemoproteins are assembled remains largely ...
Sirui Han +4 more
doaj +2 more sources
Plasmodium heme biosynthesis: To be or not to be essential?
PLoS Pathogens, 2017 Sequencing of the Plasmodium falciparum genome in 2002 sparked hopes that metabolic pathway annotation could identify new parasite-specific targets for therapeutic intervention [1].
Paul A. Sigala, Daniel E Goldberg
exaly +2 more sources
Mitochondrial ClpX activates a key enzyme for heme biosynthesis and erythropoiesis
Cell, 2015 SUMMARY The mitochondrion maintains and regulates its proteome with chaperones primarily inherited from its bacterial endosymbiont ancestor. Among these chaperones is the AAA+ unfoldase ClpX, an important regulator of prokaryotic physiology with poorly ...
J. Kardon +7 more
semanticscholar +2 more sources
Characterization of Human and Yeast Mitochondrial Glycine Carriers with Implications for Heme Biosynthesis and Anemia* [PDF]
Journal of Biological Chemistry, 2016 Heme is an essential molecule in many biological processes, such as transport and storage of oxygen and electron transfer as well as a structural component of hemoproteins.
P. Lunetti +9 more
semanticscholar +2 more sources
Frontiers in Molecular Neuroscience, 2022 BackgroundThe prognosis of diffusely infiltrating glioma patients is dismal but varies greatly between individuals. While characterization of gliomas primarily relied on histopathological features, molecular markers increasingly gained importance and ...
Mario Mischkulnig +21 more
doaj +1 more source
Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer?
Acta Biochimica Indonesiana, 2022 Heme is a compound consisting of an iron (Fe) atom bound to a pyrrole ring forming protoporphyrin IX (PPIX). Protoporphyrin combines with a protein-forming hemoprotein compound that plays an essential role in oxygen-binding and transport as well as in ...
Raisa Nauli, Sri Widia A Jusman
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2023 Heme is an important tetrapyrrole compound, and has been widely applied in food and medicine industries. Although microbial production of heme has been developed with metabolic engineering strategies during the past 20 years, the production levels are ...
Yingyu Zhou +24 more
doaj +1 more source
Fluorescence-based Heme Quantitation in Toxoplasma Gondii
Bio-Protocol, 2021 Toxoplasma gondii is a highly prevalent protozoan pathogen throughout the world. As a eukaryotic intracellular pathogen, Toxoplasma ingests nutrients from host cells to support its intracellular growth. The parasites also encode full or partial metabolic
Amy Bergmann, Zhicheng Dou
doaj +1 more source
Growth phenotype analysis of heme synthetic enzymes in a halophilic archaeon, Haloferax volcanii. [PDF]
PLoS ONE, 2017 Halophilic euryarchaea lack many of the genes necessary for the protoporphyrin-dependent heme biosynthesis pathway previously identified in animals and plants.
Naoki Kosugi +4 more
doaj +1 more source
ACS Central Science, 2021 Isonitrile natural products exhibit promising antibacterial activities. However, their mechanism of action (MoA) remains largely unknown. Based on the nanomolar potency of xanthocillin X (Xan) against diverse difficult-to-treat Gram-negative bacteria ...
Ines Hübner +8 more
semanticscholar +1 more source