Results 21 to 30 of about 42,175 (244)
Fluorescence-based Heme Quantitation in Toxoplasma Gondii
Bio-Protocol, 2021 Toxoplasma gondii is a highly prevalent protozoan pathogen throughout the world. As a eukaryotic intracellular pathogen, Toxoplasma ingests nutrients from host cells to support its intracellular growth. The parasites also encode full or partial metabolic
Amy Bergmann, Zhicheng Dou
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Growth phenotype analysis of heme synthetic enzymes in a halophilic archaeon, Haloferax volcanii. [PDF]
PLoS ONE, 2017 Halophilic euryarchaea lack many of the genes necessary for the protoporphyrin-dependent heme biosynthesis pathway previously identified in animals and plants.
Naoki Kosugi +4 more
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Frontiers in Chemistry, 2022 Cytochrome P450 enzymes (P450s) are a superfamily of monooxygenases that utilize a cysteine thiolate–ligated heme moiety to perform a wide range of demanding oxidative transformations.
Anja Greule +19 more
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Plasmodium heme biosynthesis: To be or not to be essential? [PDF]
PLoS Pathogens, 2017 Paul Sigala, Daniel Goldberg
exaly +2 more sources
Cells, 2021 Iron metabolism and heme biosynthesis are essential processes in cells during the energy cycle. Alteration in these processes could create an inflammatory condition, which results in tumorigenesis.
Dong Young Kang +4 more
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Active Turnover of Heme in Hibernation Period in Mammals
Frontiers in Physiology, 2020 Heme oxygenase (HO)-1 plays an important role during hibernation by catalyzing the degradation of heme to biliverdin/bilirubin, ferrous iron, and carbon monoxide, which activates the protective mechanisms against stress. In this context, it was important
Phil Jun Lee +5 more
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Identification of a bacteria-like ferrochelatase in Strongyloides venezuelensis, an animal parasitic nematode. [PDF]
PLoS ONE, 2013 Heme is an essential molecule for vast majority of organisms serving as a prosthetic group for various hemoproteins. Although most organisms synthesize heme from 5-aminolevulinic acid through a conserved heme biosynthetic pathway composed of seven ...
Eiji Nagayasu +6 more
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Biosynthesis of heme in leukemic leukocytes [PDF]
Cancer, 1967 The incorporation of 59Fe into heme and the synthesis of δ-aminolevulinic acid by leukocyte homogenates were studied. Whereas polymorphonudear peritoneal exudates from rabbits, as well as leukocytes from healthy adult volunteers and patients with chronic leukemia, lacked the capacity to incorporate radioiron into heme, immature leukemic cells from ...
T R, Walters +3 more
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Biosynthesis of heme in mammals
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006 Most iron in mammalian systems is routed to mitochondria to serve as a substrate for ferrochelatase. Ferrochelatase inserts iron into protoporphyrin IX to form heme which is incorporated into hemoglobin and cytochromes, the dominant hemoproteins in mammals. Tissue-specific regulatory features characterize the heme biosynthetic pathway.
Ajioka, Richard S. +2 more
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The Trypanosoma cruzi Protein TcHTE Is Critical for Heme Uptake. [PDF]
PLoS Neglected Tropical Diseases, 2016 Trypanosoma cruzi, the etiological agent of Chagas' disease, presents nutritional requirements for several metabolites. It requires heme for the biosynthesis of several heme-proteins involved in essential metabolic pathways like mitochondrial cytochromes
Marcelo L Merli +6 more
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