Results 41 to 50 of about 44,892 (270)

Fine-Tuning of hemB Using CRISPRi for Increasing 5-Aminolevulinic Acid Production in Escherichia coli

Frontiers in Microbiology, 2019
5-aminolevulinic acid (5-ALA) is an important metabolic intermediate in the biosynthesis of heme and has been broadly applied in medicine, agriculture, and organic synthesis.
Tianyuan Su, Qi Guo, Yi Zheng, Quanfeng Liang, Qian Wang, Qingsheng Qi, Qingsheng Qi   +6 more
doaj   +1 more source

Coordination of metal center biogenesis in human cytochrome c oxidase

Nature Communications, 2022
Mitochondrial cytochrome c oxidase is a heme aa3-copper oxygen reductase. Here, authors report that metal center-specific metallochaperones form dynamic assemblies to control heme a biosynthesis and coordinate copper transfer to the copper sites.
Eva Nývltová, Jonathan V. Dietz, Javier Seravalli, Oleh Khalimonchuk, Antoni Barrientos   +4 more
doaj   +1 more source

Circadian Genes Expression Patterns in Disorders Due to Enzyme Deficiencies in the Heme Biosynthetic Pathway

Biomedicines, 2022
Heme is a member of the porphyrins family of cyclic tetrapyrroles and influences various cell processes and signalling pathways. Enzyme deficiencies in the heme biosynthetic pathway provoke rare human inherited metabolic diseases called porphyrias ...
Maria Savino, Claudio Carmine Guida, Maria Nardella, Emanuele Murgo, Bartolomeo Augello, Giuseppe Merla, Salvatore De Cosmo, Antonio Fernando Savino, Roberto Tarquini, Francesco Cei, Filippo Aucella, Gianluigi Mazzoccoli   +11 more
doaj   +1 more source

Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene

Scientific Reports, 2022
In humans, disruptions in the heme biosynthetic pathway are associated with various types of porphyrias, including variegate porphyria that results from the decreased activity of protoporphyrinogen oxidase IX (PPO; E.C.1.3.3.4), the enzyme catalyzing the
Zora Novakova, Mirko Milosevic, Zsofia Kutil, Marketa Ondrakova, Barbora Havlinova, Petr Kasparek, Cristian Sandoval-Acuña, Zuzana Korandova, Jaroslav Truksa, Marek Vrbacky, Jakub Rohlena, Cyril Barinka   +11 more
doaj   +1 more source

Microbial Synthesis of Heme b: Biosynthetic Pathways, Current Strategies, Detection, and Future Prospects

Molecules, 2023
Heme b, which is characterized by a ferrous ion and a porphyrin macrocycle, acts as a prosthetic group for many enzymes and contributes to various physiological processes. Consequently, it has wide applications in medicine, food, chemical production, and
Qiuyu Yang, Juntao Zhao, Yangyang Zheng, Tao Chen, Zhiwen Wang   +4 more
doaj   +1 more source

Heme acquisition and tolerance in Gram-positive model bacteria: An orchestrated balance

Heliyon, 2023
As a nutrient, heme is important for various cellular processes of organism. Bacteria can obtain heme via heme biosynthesis or/and uptake of exogenous heme from the host. On the other side, absorption of excess heme is cytotoxic to bacteria.
Mengying Wang, Yuwei Wang, Mingshu Wang, Mafeng Liu, Anchun Cheng   +4 more
doaj   +1 more source

Development and validation of a method for porphyrins quantification using HPLC-UV in urine

Фармакокинетика и Фармакодинамика, 2022
Porphyrias are the group of orphan diseases, related to pathological disruptions of heme biosynthesis. These diseases are hard to diagnose timely and existing methods lack universality.
D. A. Kildyushkin, A. E. Petukhov, E. A. Litvin   +2 more
doaj   +1 more source

Proteomic Analysis of Ferrochelatase Interactome in Erythroid and Non-Erythroid Cells

Life, 2023
Heme is an essential cofactor for multiple cellular processes in most organisms. In developing erythroid cells, the demand for heme synthesis is high, but is significantly lower in non-erythroid cells.
Chibuike David Obi, Harry A. Dailey, Yasaman Jami-Alahmadi, James A. Wohlschlegel, Amy E. Medlock   +4 more
doaj   +1 more source

Distributions of particulate Heme b in the Atlantic and Southern Oceans-Implications for electron transport in phytoplankton

, 2013
Concentrations of heme b, the iron-containing component of b-type hemoproteins, ranged from  500). High chl a:heme b ratios resulted from relative decreases in heme b, suggesting proteins such as cytochrome b6f, the core complex of photosystem II, and ...
Nielsdottir, Maria C., Micha J. A. Rijkenberg, Achterberg, Eric P., David J. Honey, Rijkenberg, Micha J.A., Eric P. Achterberg, Maria C. Nielsdottir, Honey, David J., Rijkenberg, Micha J. A., Gledhill, Martha, Martha Gledhill   +10 more
core   +1 more source

An alternative model for heme biosynthesis in the malarial parasite

, 2007
The malarial parasite imports an infected host's red blood cell enzymes for heme biosynthesis during the intraerythrocytic stage. This is despite all the genes of the heme-biosynthetic pathway having been identified on the parasite genome.
Nagaraj, Viswanathan Arun, Rangarajan, Pundi N., Padmanaban, Govindarajan   +2 more
core   +2 more sources