Results 41 to 50 of about 732,679 (273)

An alternative model for heme biosynthesis in the malarial parasite

, 2007
The malarial parasite imports an infected host's red blood cell enzymes for heme biosynthesis during the intraerythrocytic stage. This is despite all the genes of the heme-biosynthetic pathway having been identified on the parasite genome.
Nagaraj, Viswanathan Arun, Rangarajan, Pundi N., Padmanaban, Govindarajan   +2 more
core   +2 more sources

The Trypanosoma cruzi Protein TcHTE Is Critical for Heme Uptake. [PDF]

PLoS Neglected Tropical Diseases, 2016
Trypanosoma cruzi, the etiological agent of Chagas' disease, presents nutritional requirements for several metabolites. It requires heme for the biosynthesis of several heme-proteins involved in essential metabolic pathways like mitochondrial cytochromes
Marcelo L Merli, Lucas Pagura, Josefina Hernández, María Julia Barisón, Elizabeth M F Pral, Ariel M Silber, Julia A Cricco   +6 more
doaj   +1 more source

Sedimentary Cobalt Protoporphyrin as a Potential Precursor of Prosthetic Heme Group for Bacteria Inhabiting Fossil Organic Matter-Rich Shale Rock

Biomolecules, 2021
This study hypothesizes that bacteria inhabiting shale rock affect the content of the sedimentary cobalt protoporphyrin present in it and can use it as a precursor for heme synthesis.
Robert Stasiuk, Renata Matlakowska
doaj   +1 more source

Deconvoluting heme biosynthesis to target blood-stage malaria parasites

eLife, 2015
Heme metabolism is central to blood-stage infection by the malaria parasite Plasmodium falciparum. Parasites retain a heme biosynthesis pathway but do not require its activity during infection of heme-rich erythrocytes, where they can scavenge host heme ...
Paul A Sigala, Jan R Crowley, Jeffrey P Henderson, Daniel E Goldberg   +3 more
doaj   +1 more source

The predicted heme biosynthesis pathway in sponges (modified from [61]).

, 2020
The predicted heme biosynthesis pathway in sponges (modified from [61]).
Alexander D. Finoshin (8478489), Igor A. Kosevich (8478504), Elena I. Shagimardanova (8478513), Oleg A. Gusev (8478516), Anton A. Georgiev (8478498), Kirill V. Mikhailov (6732260), Oksana I. Kravchuk (8478495), Kim I. Adameyko (8478492), Guzel R. Gazizova (8478510), Nicolay G. Gornostaev (8478501), Victor S. Mikhailov (8478507), Yulia V. Lyupina (8478519)   +11 more
core   +1 more source

Endothelin-1 Depletion of Cartilage Oligomeric Matrix Protein Modulates Pulmonary Artery Superoxide and Iron Metabolism-Associated Mitochondrial Heme Biosynthesis

, 2022
This study examines if heme biosynthesis-associated iron metabolism is regulated in pulmonary arteries by endothelin-1 (ET1) potentially through modulating cartilage oligomeric matrix protein (COMP) availability.
Wolin, Michael S, Dong Sun, Liu, Aijing, Michael S. Wolin, Aijing Liu, Wang, Yingqi, Norah Alruwaili, Hang Yu, Alruwaili, Norah, Kelly, Melissa R, Yingqi Wang, Zhang, Bin, Melissa R. Kelly, Sun, Dong, Yu, Hang, Bin Zhang   +15 more
core   +1 more source

Fine-Tuning of hemB Using CRISPRi for Increasing 5-Aminolevulinic Acid Production in Escherichia coli

Frontiers in Microbiology, 2019
5-aminolevulinic acid (5-ALA) is an important metabolic intermediate in the biosynthesis of heme and has been broadly applied in medicine, agriculture, and organic synthesis.
Tianyuan Su, Qi Guo, Yi Zheng, Quanfeng Liang, Qian Wang, Qingsheng Qi, Qingsheng Qi   +6 more
doaj   +1 more source

Coordination of metal center biogenesis in human cytochrome c oxidase

Nature Communications, 2022
Mitochondrial cytochrome c oxidase is a heme aa3-copper oxygen reductase. Here, authors report that metal center-specific metallochaperones form dynamic assemblies to control heme a biosynthesis and coordinate copper transfer to the copper sites.
Eva Nývltová, Jonathan V. Dietz, Javier Seravalli, Oleh Khalimonchuk, Antoni Barrientos   +4 more
doaj   +1 more source

Circadian Genes Expression Patterns in Disorders Due to Enzyme Deficiencies in the Heme Biosynthetic Pathway

Biomedicines, 2022
Heme is a member of the porphyrins family of cyclic tetrapyrroles and influences various cell processes and signalling pathways. Enzyme deficiencies in the heme biosynthetic pathway provoke rare human inherited metabolic diseases called porphyrias ...
Maria Savino, Claudio Carmine Guida, Maria Nardella, Emanuele Murgo, Bartolomeo Augello, Giuseppe Merla, Salvatore De Cosmo, Antonio Fernando Savino, Roberto Tarquini, Francesco Cei, Filippo Aucella, Gianluigi Mazzoccoli   +11 more
doaj   +1 more source

Protein interactions with heme are vital for pathogenic bacteria, particularly in the utilization of heme as an iron source [PDF]

, 2023
Iron is an essential nutrient for many pathogenic bacteria, and the most abundant source of the metal in the host is heme. Heme is often degraded by a heme oxygenase, and the first such enzyme (HO-1) was discovered in mammals.
Lyles, Kristin V
core   +1 more source