Results 31 to 40 of about 732,679 (273)

The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage

Frontiers in Chemistry, 2022
Cytochrome P450 enzymes (P450s) are a superfamily of monooxygenases that utilize a cysteine thiolate–ligated heme moiety to perform a wide range of demanding oxidative transformations.
Anja Greule, Anja Greule, Thierry Izoré, Thierry Izoré, Daniel Machell, Daniel Machell, Daniel Machell, Mathias H. Hansen, Mathias H. Hansen, Mathias H. Hansen, Melanie Schoppet, Melanie Schoppet, James J. De Voss, Louise K. Charkoudian, Ralf B. Schittenhelm, Ralf B. Schittenhelm, Jeffrey R. Harmer, Max J. Cryle, Max J. Cryle, Max J. Cryle   +19 more
doaj   +1 more source

New Insights into the Pivotal Role of Iron/Heme Metabolism in TLR4/NF-κB Signaling-Mediated Inflammatory Responses in Human Monocytes

Cells, 2021
Iron metabolism and heme biosynthesis are essential processes in cells during the energy cycle. Alteration in these processes could create an inflammatory condition, which results in tumorigenesis.
Dong Young Kang, Nipin Sp, Eun Seong Jo, Jin-Moo Lee, Kyoung-Jin Jang   +4 more
doaj   +1 more source

Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase

bioRxiv, 2021
Heme is an essential cofactor required for a plethora of cellular processes in eukaryotes. In metazoans the heme biosynthetic pathway is typically partitioned between the cytosol and mitochondria, with the first and final steps taking place in the ...
Jonathan V. Dietz, Mathilda M. Willoughby, Robert Piel, T. Ross, I. Bohovych, Hannah G Addis, J. Fox, W. Lanzilotta, H. Dailey, J. Wohlschlegel, Amit R. Reddi, A. Medlock, O. Khalimonchuk   +12 more
semanticscholar   +1 more source

Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α [PDF]

, 2005
Inducible hepatic porphyrias are inherited genetic disorders of enzymes of heme biosynthesis. The main clinical manifestations are acute attacks of neuropsychiatric symptoms frequently precipitated by drugs, hormones, or fasting, associated with ...
Lin, J., Handschin, Christoph, Rhee, James, Peyer, Anne-Kathrin, Meyer, Urs A, Handschin, C., Spiegelman, Bruce M, Meyer, U. A., Lin, Jiandie, Rhee, J., Wu, P. -H., Peyer, A. -K., Chin, Sherry, Spiegelman, B. M., Chin, S., Wu, Pei-Hsuan   +15 more
core   +1 more source

Structure and Function of the Bacterial Heterodimeric ABC Transporter CydDC: Stimulation of the ATPase Activity by Thiol and Heme Compounds [PDF]

, 2014
In Escherichia coli, the biogenesis of both cytochrome bd-type quinol oxidases and periplasmic cytochromes requires the ABC- type cysteine/glutathione (GSH) transporter, CydDC.
Xie, H, Poole, Robert K,, Nyathi, Yvonne, Booth, WI, Nyathi, Y, Bullough, PA, Booth, Wesley I., Xie, Hua, Postis, Vincent; id_orcid, Poole, R. K., Tzokov, Svetomir B., Booth, W.I., Postis, Vincent, Yamashita, M., Booth, W. I., Baldwin, SA, Tzokov, S, Baldwin, Stephen A., Bullough, Per A, Postis, V, Postis, V., Yamashita, Masao, Yamashita, M, Bullough, Per A., Tzokov, Svetomir, Shepherd, M., Poole, RK, Bullough, P.A., Xie, Hao, Bullough, P. A., Poole, Robert K, Poole, R.K., Booth, Wesley I, Nyathi, Y., Tzokov, S. B., Xie, H., Baldwin, Stephen A, Baldwin, S.A., Tzokov, SB, Baldwin, S. A., Shepherd, Mark, Tzokov, S.B., Shepherd, M   +42 more
core   +1 more source

Active Turnover of Heme in Hibernation Period in Mammals

Frontiers in Physiology, 2020
Heme oxygenase (HO)-1 plays an important role during hibernation by catalyzing the degradation of heme to biliverdin/bilirubin, ferrous iron, and carbon monoxide, which activates the protective mechanisms against stress. In this context, it was important
Phil Jun Lee, Phil Jun Lee, Namki Cho, Hee Min Yoo, Hong Pyo Kim, Hong Pyo Kim   +5 more
doaj   +1 more source

Identification of a bacteria-like ferrochelatase in Strongyloides venezuelensis, an animal parasitic nematode. [PDF]

PLoS ONE, 2013
Heme is an essential molecule for vast majority of organisms serving as a prosthetic group for various hemoproteins. Although most organisms synthesize heme from 5-aminolevulinic acid through a conserved heme biosynthetic pathway composed of seven ...
Eiji Nagayasu, Sohta A Ishikawa, Shigeru Taketani, Gunimala Chakraborty, Ayako Yoshida, Yuji Inagaki, Haruhiko Maruyama   +6 more
doaj   +1 more source

Biosynthesis of heme in mammals

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006
Most iron in mammalian systems is routed to mitochondria to serve as a substrate for ferrochelatase. Ferrochelatase inserts iron into protoporphyrin IX to form heme which is incorporated into hemoglobin and cytochromes, the dominant hemoproteins in mammals. Tissue-specific regulatory features characterize the heme biosynthetic pathway.
Ajioka, Richard S., Phillips, John D., Kushner, James P.   +2 more
openaire   +2 more sources

Biosynthesis of heme in leukemic leukocytes [PDF]

Cancer, 1967
The incorporation of 59Fe into heme and the synthesis of δ-aminolevulinic acid by leukocyte homogenates were studied. Whereas polymorphonudear peritoneal exudates from rabbits, as well as leukocytes from healthy adult volunteers and patients with chronic leukemia, lacked the capacity to incorporate radioiron into heme, immature leukemic cells from ...
T R, Walters, F H, Welland, T J, Gribble, H C, Schwartz   +3 more
openaire   +2 more sources

Mutation to a cytochrome P450 -like gene alters the leaf color by affecting the heme and chlorophyll biosynthesis pathways in Brassica napus.

The Plant Journal, 2023
The regulated biosynthesis of chlorophyll is important because of its effects on plant photosynthesis and dry biomass production. In this study, a map-based cloning approach was used to isolate the cytochrome P450 -like gene BnaC08g34840D (BnCDE1) from a
Mao Yang, Shubei Wan, Jun Chen, Wenjing Chen, Yangming Wang, Weiya Li, Meihong Wang, Rong-Zhan Guan   +7 more
semanticscholar   +1 more source