Results 31 to 40 of about 44,892 (270)
Active Turnover of Heme in Hibernation Period in Mammals
Frontiers in Physiology, 2020 Heme oxygenase (HO)-1 plays an important role during hibernation by catalyzing the degradation of heme to biliverdin/bilirubin, ferrous iron, and carbon monoxide, which activates the protective mechanisms against stress. In this context, it was important
Phil Jun Lee +5 more
doaj +1 more source
Identification of a bacteria-like ferrochelatase in Strongyloides venezuelensis, an animal parasitic nematode. [PDF]
PLoS ONE, 2013 Heme is an essential molecule for vast majority of organisms serving as a prosthetic group for various hemoproteins. Although most organisms synthesize heme from 5-aminolevulinic acid through a conserved heme biosynthetic pathway composed of seven ...
Eiji Nagayasu +6 more
doaj +1 more source
Biosynthesis of heme in leukemic leukocytes [PDF]
Cancer, 1967 The incorporation of 59Fe into heme and the synthesis of δ-aminolevulinic acid by leukocyte homogenates were studied. Whereas polymorphonudear peritoneal exudates from rabbits, as well as leukocytes from healthy adult volunteers and patients with chronic leukemia, lacked the capacity to incorporate radioiron into heme, immature leukemic cells from ...
T R, Walters +3 more
openaire +2 more sources
Biosynthesis of heme in mammals
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006 Most iron in mammalian systems is routed to mitochondria to serve as a substrate for ferrochelatase. Ferrochelatase inserts iron into protoporphyrin IX to form heme which is incorporated into hemoglobin and cytochromes, the dominant hemoproteins in mammals. Tissue-specific regulatory features characterize the heme biosynthetic pathway.
Ajioka, Richard S. +2 more
openaire +2 more sources
The Trypanosoma cruzi Protein TcHTE Is Critical for Heme Uptake. [PDF]
PLoS Neglected Tropical Diseases, 2016 Trypanosoma cruzi, the etiological agent of Chagas' disease, presents nutritional requirements for several metabolites. It requires heme for the biosynthesis of several heme-proteins involved in essential metabolic pathways like mitochondrial cytochromes
Marcelo L Merli +6 more
doaj +1 more source
Deconvoluting heme biosynthesis to target blood-stage malaria parasites
eLife, 2015 Heme metabolism is central to blood-stage infection by the malaria parasite Plasmodium falciparum. Parasites retain a heme biosynthesis pathway but do not require its activity during infection of heme-rich erythrocytes, where they can scavenge host heme ...
Paul A Sigala +3 more
doaj +1 more source
Biosynthesis of High‐Active Hemoproteins by the Efficient Heme‐Supply Pichia Pastoris Chassis
Advanced Science, 2023 Microbial synthesis of valuable hemoproteins has become a popular research topic, and Pichia pastoris is a versatile platform for the industrial production of recombinant proteins.
Fei Yu +6 more
doaj +1 more source
Biomolecules, 2021 This study hypothesizes that bacteria inhabiting shale rock affect the content of the sedimentary cobalt protoporphyrin present in it and can use it as a precursor for heme synthesis.
Robert Stasiuk, Renata Matlakowska
doaj +1 more source
Am J Physiol Lung Cell Mol Physiol, 2022 This study examines if heme biosynthesis-associated iron metabolism is regulated in pulmonary arteries by endothelin-1 (ET1) potentially through modulating cartilage oligomeric matrix protein (COMP) availability.
Yu H +7 more
europepmc +2 more sources
Biotechnology for Biofuels and Bioproducts, 2023 Background Heme has attracted much attention because of its wide applications in medicine and food. The products of genes hemBCDEFY convert 5-aminolevulinic acid to protoporphyrin IX (PPIX; the immediate precursor of heme); protoporphyrin ferrochelatase (
Jian Zhang +7 more
doaj +1 more source