Results 31 to 40 of about 11,782 (206)

DataSheet1_In Campylobacter jejuni, a new type of chaperone receives heme from ferrochelatase.docx [PDF]

, 2023
Intracellular heme formation and trafficking are fundamental processes in living organisms. Bacteria and archaea utilize three biogenesis pathways to produce iron protoporphyrin IX (heme b) that diverge after the formation of the common intermediate ...
Frederico M. Lourenço, Frederico M. Lourenço (16409352), Lígia M. Saraiva (501957), Jordi Zamarreño Beas, Mafalda R. Almeida, Jordi Zamarreño Beas (9592457), Val Karavaeva (16409349), Filipa Sousa (6595073), Lígia M. Saraiva, Mafalda R. Almeida (6666956), Val Karavaeva, Marco A. M. Videira, Filipa Sousa, Marco A. M. Videira (16409346)   +13 more
core   +1 more source

The Regulatory Function of Heme Oxygenase in Modulating Mammalian Heme Bioavailability and Homeostasis [PDF]

, 2022
Heme is an essential cofactor that participates in a myriad of biological processes. The vast number and variety of heme-associated processes necessitates the tightly controlled distribution and bioavailability of heme to ensure its proper amount and ...
Liu, Liu
core   +1 more source

Heme Trafficking and Modifications during System I Cytochrome c Biogenesis: Insights from Heme Redox Potentials of Ccm Proteins. [PDF]

Biochemistry, 2016
Cytochromes c require covalent attachment of heme via two thioether bonds at conserved CXXCH motifs, a process accomplished in prokaryotes by eight integral membrane proteins (CcmABCDEFGH), termed System I. Heme is trafficked from inside the cell to outside (via CcmABCD) and chaperoned (holoCcmE) to the cytochrome c synthetase (CcmF/H). Purification of
Sutherland MC, Rankin JA, Kranz RG.
europepmc   +4 more sources

Heme Oxygenase-1 Regulates Myeloid Cell Trafficking in AKI [PDF]

Journal of the American Society of Nephrology, 2015
Renal ischemia-reperfusion injury is mediated by a complex cascade of events, including the immune response, that occur secondary to injury to renal epithelial cells. We tested the hypothesis that heme oxygenase-1 (HO-1) expression, which is protective in ischemia-reperfusion injury, regulates trafficking of myeloid-derived immune cells in the kidney ...
Travis D, Hull, Ahmed I, Kamal, Ravindra, Boddu, Subhashini, Bolisetty, Lingling, Guo, Cornelia C, Tisher, Sunil, Rangarajan, Bo, Chen, Lisa M, Curtis, James F, George, Anupam, Agarwal   +10 more
openaire   +2 more sources

Heme degrading protein HemS is involved in oxidative stress response of Bartonella henselae. [PDF]

PLoS ONE, 2012
Bartonellae are hemotropic bacteria, agents of emerging zoonoses. These bacteria are heme auxotroph Alphaproteobacteria which must import heme for supporting their growth, as they cannot synthesize it.
MaFeng Liu, Henri-Jean Boulouis, Francis Biville   +2 more
doaj   +1 more source

Genetic screens reveal CCDC115 as a modulator of erythroid iron and heme trafficking [PDF]

American Journal of Hematology, 2020
AbstractTransferrin‐bound iron (TBI), the physiological circulating iron form, is acquired by cells through the transferrin receptor (TfR1) by endocytosis. In erythroid cells, most of the acquired iron is incorporated into heme in the mitochondria. Cellular trafficking of heme is indispensable for erythropoiesis and many other essential biological ...
Amin Sobh, Alex Loguinov, Jie Zhou, Supak Jenkitkasemwong, Rola Zeidan, Nader El Ahmadie, Abderrahmane Tagmount, Mitchell Knutson, Paula G. Fraenkel, Christopher D. Vulpe   +9 more
openaire   +2 more sources

Down the Iron Path: Mitochondrial Iron Homeostasis and Beyond

Cells, 2021
Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent. Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate these cofactors along with iron ions into mitochondrial proteins that support ...
Jonathan V. Dietz, Jennifer L. Fox, Oleh Khalimonchuk   +2 more
doaj   +1 more source

Progesterone receptor membrane component 1 (PGRMC1) regulates Heme trafficking through mitochondria-ER junctions. [PDF]

J Inorg Biochem
Heme is a cofactor essential for a multitude of biological reactions. The terminal step of heme synthesis occurs in the mitochondrial matrix which means that heme must be trafficked from there to other locales in the cell. Thus, identifying intracellular heme chaperones is crucial to understanding regulation of global cellular metabolism.
Piel Iii RB, Obi CD, Viana MP, Willoughby MM, Martinez-Guzman O, Wadley A, Jami-Alahmadi Y, Wohlschlegel JA, Hicks KG, Rutter J, Maschek JA, Catrow JL, Cox J, Reddi AR, Khalimonchuk O, Medlock AE.   +15 more
europepmc   +3 more sources

Biosynthesis and trafficking of heme o and heme a: new structural insights and their implications for reaction mechanisms and prenylated heme transfer

Critical Reviews in Biochemistry and Molecular Biology, 2021
Aerobic respiration is a key energy-producing pathway in many prokaryotes and virtually all eukaryotes. The final step of aerobic respiration is most commonly catalyzed by heme-copper oxidases embedded in the cytoplasmic or mitochondrial membrane. The majority of these terminal oxidases contain a prenylated heme (typically heme a or occasionally heme o)
Elise D. Rivett, Lim Heo, Michael Feig, Eric L. Hegg   +3 more
openaire   +3 more sources

Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans. [PDF]

PLoS Genetics, 2010
Heme is a cofactor in proteins that function in almost all sub-cellular compartments and in many diverse biological processes. Heme is produced by a conserved biosynthetic pathway that is highly regulated to prevent the accumulation of heme--a cytotoxic,
Scott Severance, Abbhirami Rajagopal, Anita U Rao, Gustavo C Cerqueira, Makedonka Mitreva, Najib M El-Sayed, Michael Krause, Iqbal Hamza   +7 more
doaj   +1 more source