Results 31 to 40 of about 11,485 (176)

Progesterone receptor membrane component 1 (PGRMC1) regulates Heme trafficking through mitochondria-ER junctions. [PDF]

J Inorg Biochem
Heme is a cofactor essential for a multitude of biological reactions. The terminal step of heme synthesis occurs in the mitochondrial matrix which means that heme must be trafficked from there to other locales in the cell. Thus, identifying intracellular heme chaperones is crucial to understanding regulation of global cellular metabolism.
Piel Iii RB, Obi CD, Viana MP, Willoughby MM, Martinez-Guzman O, Wadley A, Jami-Alahmadi Y, Wohlschlegel JA, Hicks KG, Rutter J, Maschek JA, Catrow JL, Cox J, Reddi AR, Khalimonchuk O, Medlock AE.   +15 more
europepmc   +3 more sources

Heme degrading protein HemS is involved in oxidative stress response of Bartonella henselae. [PDF]

PLoS ONE, 2012
Bartonellae are hemotropic bacteria, agents of emerging zoonoses. These bacteria are heme auxotroph Alphaproteobacteria which must import heme for supporting their growth, as they cannot synthesize it.
MaFeng Liu, Henri-Jean Boulouis, Francis Biville   +2 more
doaj   +1 more source

Down the Iron Path: Mitochondrial Iron Homeostasis and Beyond

Cells, 2021
Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent. Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate these cofactors along with iron ions into mitochondrial proteins that support ...
Jonathan V. Dietz, Jennifer L. Fox, Oleh Khalimonchuk   +2 more
doaj   +1 more source

Biosynthesis and trafficking of heme o and heme a: new structural insights and their implications for reaction mechanisms and prenylated heme transfer

Critical Reviews in Biochemistry and Molecular Biology, 2021
Aerobic respiration is a key energy-producing pathway in many prokaryotes and virtually all eukaryotes. The final step of aerobic respiration is most commonly catalyzed by heme-copper oxidases embedded in the cytoplasmic or mitochondrial membrane. The majority of these terminal oxidases contain a prenylated heme (typically heme a or occasionally heme o)
Elise D. Rivett, Lim Heo, Michael Feig, Eric L. Hegg   +3 more
openaire   +3 more sources

The Trypanosoma cruzi Protein TcHTE Is Critical for Heme Uptake. [PDF]

PLoS Neglected Tropical Diseases, 2016
Trypanosoma cruzi, the etiological agent of Chagas' disease, presents nutritional requirements for several metabolites. It requires heme for the biosynthesis of several heme-proteins involved in essential metabolic pathways like mitochondrial cytochromes
Marcelo L Merli, Lucas Pagura, Josefina Hernández, María Julia Barisón, Elizabeth M F Pral, Ariel M Silber, Julia A Cricco   +6 more
doaj   +1 more source

An Intercellular Heme-Trafficking Protein Delivers Maternal Heme to the Embryo during Development in C. elegans [PDF]

Cell, 2011
Extracellular free heme can intercalate into membranes and promote damage to cellular macromolecules. Thus it is likely that specific intercellular pathways exist for the directed transport, trafficking, and delivery of heme to cellular destinations, although none have been found to date.
Chen, Caiyong, Samuel, Tamika K., Sinclair, Jason, Dailey, Harry A., Hamza, Iqbal   +4 more
openaire   +2 more sources

Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans. [PDF]

PLoS Genetics, 2010
Heme is a cofactor in proteins that function in almost all sub-cellular compartments and in many diverse biological processes. Heme is produced by a conserved biosynthetic pathway that is highly regulated to prevent the accumulation of heme--a cytotoxic,
Scott Severance, Abbhirami Rajagopal, Anita U Rao, Gustavo C Cerqueira, Makedonka Mitreva, Najib M El-Sayed, Michael Krause, Iqbal Hamza   +7 more
doaj   +1 more source

F-actin and myosin F control apicoplast elongation dynamics which drive apicoplast-centrosome association in Toxoplasma gondii

mBio, 2023
Toxoplasma gondii contains an essential plastid organelle called the apicoplast that is necessary for fatty acid, isoprenoid, and heme synthesis. Perturbations affecting apicoplast function or inheritance lead to parasite death.
Parvathi Madhavi Devarakonda, Valeria Sarmiento, Aoife T. Heaslip   +2 more
doaj   +1 more source

CytochromecBiogenesis: Mechanisms for Covalent Modifications and Trafficking of Heme and for Heme-Iron Redox Control [PDF]

Microbiology and Molecular Biology Reviews, 2009
SUMMARYHeme is the prosthetic group for cytochromes, which are directly involved in oxidation/reduction reactions inside and outside the cell. Many cytochromes contain heme with covalent additions at one or both vinyl groups. These include farnesylation at one vinyl in hemesoandaand thioether linkages to each vinyl in cytochromec(at CXXCH of the ...
Robert G, Kranz, Cynthia, Richard-Fogal, John-Stephen, Taylor, Elaine R, Frawley   +3 more
openaire   +2 more sources

Active Turnover of Heme in Hibernation Period in Mammals

Frontiers in Physiology, 2020
Heme oxygenase (HO)-1 plays an important role during hibernation by catalyzing the degradation of heme to biliverdin/bilirubin, ferrous iron, and carbon monoxide, which activates the protective mechanisms against stress. In this context, it was important
Phil Jun Lee, Phil Jun Lee, Namki Cho, Hee Min Yoo, Hong Pyo Kim, Hong Pyo Kim   +5 more
doaj   +1 more source