Results 11 to 20 of about 213,829 (198)
From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme [PDF]
Cells, 2020 Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo ...
Samantha A. Swenson +5 more
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Hemoglobin Endocytosis and Intracellular Trafficking: A Novel Way of Heme Acquisition by Leishmania
Pathogens, 2022 Leishmania species are causative agents of human leishmaniasis, affecting 12 million people annually. Drugs available for leishmaniasis are toxic, and no vaccine is available. Thus, the major thrust is to identify new therapeutic targets.
Irshad Ansari +2 more
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Heme, an iron-containing organic ring, is a vital cofactor responsible for diverse biologicalfunctions and is the major source of bioavailable iron in the human diet.
Dutt, Sohini
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Intracellular iron and heme trafficking and metabolism in developing erythroblasts. [PDF]
Metallomics, 2017 Vertebrate red blood cells (RBCs) arise from erythroblasts in the human bone marrow through a process known as erythropoiesis.
Kafina MD, Paw BH.
europepmc +4 more sources
Key roles of GAPDH, Hsp90, and NO in heme trafficking. [PDF]
J Inorg BiochemIntracellular trafficking of mitochondrial heme to create functional heme proteins presents a fundamental challenge in animal cells. This article provides some background on heme allocation, discusses some of the concepts, and then reviews research from the last two decades that has uncovered unexpected and important roles for glyceraldehyde 3 ...
Stuehr DJ +6 more
europepmc +4 more sources
Heme Gazing: Illuminating Eukaryotic Heme Trafficking, Dynamics, and Signaling with Fluorescent Heme Sensors. [PDF]
Biochemistry, 2017 Heme (iron protoporphyrin IX) is an essential protein prosthetic group and signaling molecule required for most life on Earth. All heme-dependent processes require the dynamic and rapid mobilization of heme from sites of synthesis or uptake to hemoproteins present in virtually every subcellular compartment.
Hanna DA, Martinez-Guzman O, Reddi AR.
europepmc +4 more sources
A new member of the flavodoxin superfamily from Fusobacterium nucleatum that functions in heme trafficking and reduction of anaerobilin. [PDF]
J Biol Chem, 2023 Fusobacterium nucleatum is an opportunistic oral pathogen that is associated with various cancers. To fulfill its essential need for iron, this anaerobe will express heme uptake machinery encoded at a single genetic locus. The heme uptake operon includes HmuW, a class C radical SAM-dependent methyltransferase that degrades heme anaerobically to release
McGregor AK +6 more
europepmc +3 more sources
Interaction of holoCcmE with CcmF in heme trafficking and cytochrome c biosynthesis. [PDF]
J Mol Biol, 2014 The periplasmic heme chaperone holoCcmE is essential for heme trafficking in the cytochrome c biosynthetic pathway in many bacteria, archaea, and plant mitochondria. This pathway, called system I, involves two steps: (i) formation and release of holoCcmE (by the ABC-transporter complex CcmABCD) and (ii) delivery of the heme in holoCcmE to the putative ...
San Francisco B, Kranz RG.
europepmc +4 more sources
HEME Trafficking by the Cytochrome C Biogenesis Pathways [PDF]
Biophysical Journal, 2017 Cytochromes function in electron transport chains to perform critical cellular functions, such as respiration and photosynthesis. Cytochromes c are unique due to their requirement for the covalent attachment of heme via two thioether bonds at a conserved CXXCH motif. Three pathways have been identified for cytochrome c maturation: System I (prokaryotes)
Molly C. Sutherland +2 more
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Ferric reductase-related proteins mediate fungal heme acquisition
eLife, 2022 Heme can serve as iron source in many environments, including the iron-poor animal host environment. The fungal pathobiont Candida albicans expresses a family of extracellular CFEM hemophores that capture heme from host proteins and transfer it across ...
Udita Roy +6 more
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