Hemoglobin Endocytosis and Intracellular Trafficking: A Novel Way of Heme Acquisition by Leishmania [PDF]
Pathogens, 2022 Leishmania species are causative agents of human leishmaniasis, affecting 12 million people annually. Drugs available for leishmaniasis are toxic, and no vaccine is available. Thus, the major thrust is to identify new therapeutic targets.
Irshad Ansari +2 more
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From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme [PDF]
Cells, 2020 Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo ...
Samantha A. Swenson +5 more
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Structure-Function Analysis of the Bifunctional CcsBA Heme Exporter and Cytochrome
mBio, 2018 Although intracellular heme trafficking must occur for heme protein assembly, only a few heme transporters have been unequivocally discovered and nothing is known about their structure or mechanisms.
Molly C. Sutherland +5 more
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Identification of the Mitochondrial Heme Metabolism Complex. [PDF]
PLoS ONE, 2015 Heme is an essential cofactor for most organisms and all metazoans. While the individual enzymes involved in synthesis and utilization of heme are fairly well known, less is known about the intracellular trafficking of porphyrins and heme, or regulation ...
Amy E Medlock +6 more
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Role of Heme in Intracellular Trafficking of Thyroperoxidase and Involvement of H 2 O 2 Generated at the Apical Surface of Thyroid Cells in Autocatalytic Covalent Heme Binding [PDF]
Journal of Biological Chemistry, 1999 International audienceThyroperoxidase (TPO) is a glycosylated hemoprotein that plays a key role in thyroid hormone synthesis. We previously showed that in CHO cells expressing human TPO (hTPO) only 2% of synthesized hTPO reaches the cell surface. Herein,
Fayadat, Laurence +3 more
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The Trypanosoma cruzi Protein TcHTE Is Critical for Heme Uptake. [PDF]
PLoS Neglected Tropical Diseases, 2016 Trypanosoma cruzi, the etiological agent of Chagas' disease, presents nutritional requirements for several metabolites. It requires heme for the biosynthesis of several heme-proteins involved in essential metabolic pathways like mitochondrial cytochromes
Marcelo L Merli +6 more
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COORDINATED TRAFFICKING OF HEME TRANSPORTERS BY CARGO SORTING COMPLEXES IS ESSENTIAL FOR ORGANISMAL HEME HOMEOSTASIS [PDF]
Heme, an iron-containing organic ring, is a vital cofactor responsible for diverse biologicalfunctions and is the major source of bioavailable iron in the human diet.
Dutt, Sohini
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Cj1386 Is an Ankyrin-Containing Protein Involved in Heme Trafficking to Catalase in Campylobacter jejuni [PDF]
Journal of Bacteriology, 2012 Campylobacter jejuni , a microaerophilic bacterium, is the most frequent cause of human bacterial gastroenteritis. C. jejuni is exposed to harmful reactive oxygen species (ROS) produced during its own normal metabolic ...
Yi-Qian Sun, Annika Flint, Alain Stintzi
core +4 more sources
Investigating the Connection Between Endogenous Heme Accumulation and COX2 Activity in Cancer Cells [PDF]
Frontiers in Oncology, 2019 Heme, an iron-containing porphyrin, is fundamental for a variety of functions in cell homeostasis. Nevertheless, recent data indicate that dysregulation of heme metabolism might promote tumorigenesis.
Francesca Destefanis +3 more
doaj +3 more sources
HDP-a novel heme detoxification protein from the malaria parasite. [PDF]
PLoS Pathogens, 2008 When malaria parasites infect host red blood cells (RBC) and proteolyze hemoglobin, a unique, albeit poorly understood parasite-specific mechanism, detoxifies released heme into hemozoin (Hz).
Dewal Jani +7 more
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