Results 1 to 10 of about 260 (109)
Coordination of metal center biogenesis in human cytochrome c oxidase
Nature Communications, 2022 Mitochondrial cytochrome c oxidase is a heme aa3-copper oxygen reductase. Here, authors report that metal center-specific metallochaperones form dynamic assemblies to control heme a biosynthesis and coordinate copper transfer to the copper sites.
Eva Nývltová +4 more
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Inhibitors of cytochrome c biogenesis pathways
mBioThe unique composition of bacterial electron transport chains (ETCs), distinct from the human mitochondrial ETC, presents opportunities for selective antibacterial targeting.
Deanna L. Mendez +8 more
doaj +3 more sources
HIGD-Driven Regulation of Cytochrome c Oxidase Biogenesis and Function [PDF]
Cells, 2020 The biogenesis and function of eukaryotic cytochrome c oxidase or mitochondrial respiratory chain complex IV (CIV) undergo several levels of regulation to adapt to changing environmental conditions. Adaptation to hypoxia and oxidative stress involves CIV
Alba Timón-Gómez +3 more
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A Pivotal Heme-Transfer Reaction Intermediate in Cytochrome c Biogenesis [PDF]
Journal of Biological Chemistry, 2012 c-Type cytochromes are widespread proteins, fundamental for respiration or photosynthesis in most cells. They contain heme covalently bound to protein in a highly conserved, highly stereospecific post-translational modification. In many bacteria, mitochondria, and archaea this heme attachment is catalyzed by the cytochrome c maturation (Ccm) proteins ...
Despoina A.I. Mavridou +2 more
exaly +4 more sources
A Novel Pathway for Cytochromes c Biogenesis in Chloroplasts
Biochimica Et Biophysica Acta - Bioenergetics, 1998 The cytochromes c are a useful model for the study of the pathways and mechanisms of assembly of the cofactor-containing components of energy transducing membranes. Genetic analyses have identified proteins that are required for the assembly of c-type cytochromes in mitochondria, bacteria and chloroplasts.
Sabeeha Merchant
exaly +3 more sources
Cox1 mutation abrogates need for Cox23 in cytochrome c oxidase biogenesis [PDF]
Microbial Cell, 2016 Cox23 is a known conserved assembly factor for cytochrome c oxidase, although its role in cytochrome c oxidase (CcO) biogenesis remains unresolved. To gain additional insights into its role, we isolated spontaneous suppressors of the respiratory growth ...
Richard Dela Cruz +2 more
doaj +3 more sources
In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases
eLife, 2021 Cytochromes c are ubiquitous heme proteins in mitochondria and bacteria, all possessing a CXXCH (CysXxxXxxCysHis) motif with covalently attached heme. We describe the first in vitro reconstitution of cytochrome c biogenesis using purified mitochondrial ...
Molly C Sutherland +8 more
doaj +1 more source
Selenite stimulates mitochondrial biogenesis signaling and enhances mitochondrial functional performance in murine hippocampal neuronal cells. [PDF]
PLoS ONE, 2012 Supplementation of selenium has been shown to protect cells against free radical mediated cell damage. The objectives of this study are to examine whether supplementation of selenium stimulates mitochondrial biogenesis signaling pathways and whether ...
Natalia Mendelev +4 more
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Cytochrome c biogenesis: the Ccm system [PDF]
Trends in Microbiology, 2010 Cytochromes of c-type contain covalently attached hemes that are formed via thioether bonds between the vinyls of heme b and cysteines within C(1)XXC(2)H motifs of apocytochromes. In diverse organisms this post-translational modification relies on membrane-associated specific biogenesis proteins, referred to as cytochrome c maturation (Ccm) systems.
Carsten, Sanders +3 more
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Cytochrome c biogenesis System I [PDF]
The FEBS Journal, 2011 Cytochromes c are widespread respiratory proteins characterized by the covalent attachment of heme. The formation of c ‐type cytochromes requires, in all but a few exceptional cases, the formation of two thioether bonds between the two cysteine sulfurs ...
Julie M. Stevens +5 more
openaire +3 more sources