Results 1 to 10 of about 42,954 (256)

A Pivotal Heme-transfer Reaction Intermediate in Cytochrome c Biogenesis [PDF]

Journal of Biological Chemistry, 2012
c-Type cytochromes are widespread proteins, fundamental for respiration or photosynthesis in most cells. They contain heme covalently bound to protein in a highly conserved, highly stereospecific post-translational modification. In many bacteria, mitochondria, and archaea this heme attachment is catalyzed by the cytochrome c maturation (Ccm) proteins ...
Despoina A I Mavridou, Julie M Stevens, Oliver Daltrop   +2 more
exaly   +8 more sources

Coordination of metal center biogenesis in human cytochrome c oxidase [PDF]

Nature Communications, 2022
Mitochondrial cytochrome c oxidase is a heme aa3-copper oxygen reductase. Here, authors report that metal center-specific metallochaperones form dynamic assemblies to control heme a biosynthesis and coordinate copper transfer to the copper sites.
Eva Nývltová, Jonathan V. Dietz, Javier Seravalli, Oleh Khalimonchuk, Antoni Barrientos   +4 more
doaj   +7 more sources

Inhibitors of cytochrome c biogenesis pathways [PDF]

mBio
The unique composition of bacterial electron transport chains (ETCs), distinct from the human mitochondrial ETC, presents opportunities for selective antibacterial targeting.
Deanna L. Mendez, Pema L. Childs, Amidala J. Martinie, Jonathan Q. Huynh, Andy F. Zhu, Samuel R. McKee, George S. Ghabrial, Christina L. Stallings, Robert G. Kranz   +8 more
doaj   +3 more sources

Cytochrome c biogenesis System I [PDF]

FEBS Journal, 2011
Cytochromes c are widespread respiratory proteins characterized by the covalent attachment of heme. The formation of c‐type cytochromes requires, in all but a few exceptional cases, the formation of two thioether bonds between the two cysteine sulfurs in a –CXXCH– motif in the protein and the vinyl groups of heme.
Julie M Stevens, Despoina A I Mavridou, Rebecca Hamer   +2 more
exaly   +6 more sources

Biochemical mapping reveals a conserved heme transport mechanism via CcmCD in System I bacterial cytochrome c biogenesis [PDF]

mBio
Heme is a redox-active cofactor for essential processes across all domains of life. Heme’s redox capabilities are responsible for its biological significance but also make it highly cytotoxic, requiring tight intracellular regulation.
Alicia N. Kreiman, Sarah E. Garner, Susan C. Carroll, Molly C. Sutherland   +3 more
doaj   +2 more sources

Mitochondrial cytochrome c biogenesis: no longer an enigma. [PDF]

Trends Biochem Sci, 2015
Cytochromes c (cyt c) and c1 are heme proteins that are essential for aerobic respiration. Release of cyt c from mitochondria is an important signal in apoptosis initiation. Biogenesis of c-type cytochromes involves covalent attachment of heme to two cysteines (at a conserved CXXCH sequence) in the apocytochrome.
Babbitt SE, Sutherland MC, San Francisco B, Mendez DL, Kranz RG.   +4 more
europepmc   +4 more sources

Analysis of putative heme ligands in the System I bacterial cytochrome c biogenesis heme transporter, CcmCD [PDF]

Microbiology Spectrum
Heme is a key co-factor for biologically important proteins that are required for critical cellular functions such as oxygen transport and energy production.
Alicia N. Kreiman, Susan C. Carroll, Nikita P. Varde, Sarah E. Garner, Donna R. Price, Molly C. Sutherland   +5 more
doaj   +2 more sources

Continued surprises in the cytochrome c biogenesis story. [PDF]

Protein Cell, 2012
Cytochromes c covalently bind their heme prosthetic groups through thioether bonds between the vinyl groups of the heme and the thiols of a CXXCH motif within the protein. In Gram-negative bacteria, this process is catalyzed by the Ccm (cytochrome c maturation) proteins, also called System I.
Sawyer EB, Barker PD.
europepmc   +4 more sources

Cytochrome c biogenesis: the Ccm system. [PDF]

Trends Microbiol, 2010
Cytochromes of c-type contain covalently attached hemes that are formed via thioether bonds between the vinyls of heme b and cysteines within C(1)XXC(2)H motifs of apocytochromes. In diverse organisms this post-translational modification relies on membrane-associated specific biogenesis proteins, referred to as cytochrome c maturation (Ccm) systems.
Sanders C, Turkarslan S, Lee DW, Daldal F.   +3 more
europepmc   +4 more sources

HIGD-Driven Regulation of Cytochrome c Oxidase Biogenesis and Function [PDF]

Cells, 2020
The biogenesis and function of eukaryotic cytochrome c oxidase or mitochondrial respiratory chain complex IV (CIV) undergo several levels of regulation to adapt to changing environmental conditions. Adaptation to hypoxia and oxidative stress involves CIV
Alba Timón-Gómez, Emma L. Bartley-Dier, Flavia Fontanesi, Antoni Barrientos   +3 more
doaj   +3 more sources