Results 11 to 20 of about 42,954 (256)
Cox1 mutation abrogates need for Cox23 in cytochrome c oxidase biogenesis [PDF]
Microbial Cell, 2016 Cox23 is a known conserved assembly factor for cytochrome c oxidase, although its role in cytochrome c oxidase (CcO) biogenesis remains unresolved. To gain additional insights into its role, we isolated spontaneous suppressors of the respiratory growth ...
Richard Dela Cruz +2 more
doaj +5 more sources
Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core [PDF]
Biochimica Et Biophysica Acta - Bioenergetics, 2012 Eukaryotic cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. COX is a multimeric enzyme formed by subunits of dual genetic origin which assembly is intricate and highly regulated. The COX catalytic core is formed by three mitochondrial DNA encoded subunits, Cox1, Cox2 and Cox3, conserved in the bacterial enzyme ...
Flavia Fontanesi, Antoni Barrientos
exaly +4 more sources
Comparing substrate specificity between cytochrome c maturation and cytochrome c heme lyase systems for cytochrome c biogenesis [PDF]
Metallomics, 2011 Hemes c are characterized by their covalent attachment to a polypeptide via a widely conserved CXXCH motif. There are multiple biological systems that facilitate heme c biogenesis. System I, the cytochrome c maturation (CCM) system, is found in many bacteria and is commonly employed in the maturation of bacterial cytochromes c in Escherichia coli-based
Jesse G, Kleingardner, Kara L, Bren
openaire +4 more sources
Cytochrome c biogenesis in bacteria [PDF]
, 1998 Cytochromes c are electron transfer proteins in which haem is covalently attached to the polypeptide chain via thioether bonds formed from thiol groups of the two cysteines and the two vinyl groups of haem. This attachment is a post translational process and in many species of bacteria as many as approximately twelve gene products, the functions of ...
Sinha, N, Sinha, Neeti
core +7 more sources
In vitro studies on cytochrome c biogenesis [PDF]
, 2003 C-type cytochromes are essential for almost all organisms and are mainly involved in electron transport; they are characterised by the covalent attachment of heme to protein through two thioether bonds to a CXXCH peptide motif. This thesis describes the development of in vitro systems to establish chemical aspects of the process of cytochrome c ...
Daltrop, O, Daltrop, Oliver
core +8 more sources
Exosome profile and composite indices reflect immune exhaustion in periodontitis [PDF]
Scientific ReportsIntroduction Exosomes are small extracellular vesicles that regulate immune responses, inflammation, and tissue homeostasis. While several exosomal molecules have been investigated individually in periodontitis, a functional characterization based on ...
Marco Bonilla +3 more
doaj +2 more sources
Composition and function of cytochrome c biogenesis System II [PDF]
The FEBS Journal, 2011 Organisms employ one of several different enzyme systems to mature cytochromes c. The biosynthetic process involves the periplasmic reduction of cysteine residues in the heme c attachment motif of the apocytochrome, transmembrane transport of heme b and stereospecific covalent heme attachment via thioether bonds. The biogenesis System II (or Ccs system)
Jörg, Simon, Lars, Hederstedt
openaire +4 more sources
Mitochondrial cytochrome c oxidase biogenesis: Recent developments
Seminars in Cell and Developmental Biology, 2018 Mitochondrial cytochrome c oxidase (COX) is the primary site of cellular oxygen consumption and is essential for aerobic energy generation in the form of ATP. Human COX is a copper-heme A hetero-multimeric complex formed by 3 catalytic core subunits encoded in the mitochondrial DNA and 11 subunits encoded in the nuclear genome.
Alba Timón-Gómez +2 more
exaly +6 more sources
Biogenesis of cbb3-type cytochrome c oxidase in Rhodobacter capsulatus [PDF]
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012 The cbb(3)-type cytochrome c oxidases (cbb(3)-Cox) constitute the second most abundant cytochrome c oxidase (Cox) group after the mitochondrial-like aa(3)-type Cox. They are present in bacteria only, and are considered to represent a primordial innovation in the domain of Eubacteria due to their phylogenetic distribution and their similarity to nitric ...
Ekici, Seda +4 more
core +5 more sources
Structurally Mapping Endogenous Heme in the CcmCDE Membrane Complex for Cytochrome c Biogenesis [PDF]
Journal of Molecular Biology, 2018 Molly C Sutherland +2 more
exaly +2 more sources