Results 11 to 20 of about 19,855,151 (220)
Comparing substrate specificity between cytochrome c maturation and cytochrome c heme lyase systems for cytochrome c biogenesis [PDF]
Metallomics, 2011 Hemes c are characterized by their covalent attachment to a polypeptide via a widely conserved CXXCH motif. There are multiple biological systems that facilitate heme c biogenesis. System I, the cytochrome c maturation (CCM) system, is found in many bacteria and is commonly employed in the maturation of bacterial cytochromes c in Escherichia coli-based
Jesse G, Kleingardner, Kara L, Bren
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MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly [PDF]
Cell Reports, 2015 Cytochrome c oxidase, the terminal enzyme of the respiratory chain, is assembled from mitochondria- and nuclear-encoded subunits. The MITRAC complex represents the central assembly intermediate during this process as it receives imported subunits and ...
Sven Dennerlein +8 more
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Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012 Eukaryotic cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. COX is a multimeric enzyme formed by subunits of dual genetic origin which assembly is intricate and highly regulated. The COX catalytic core is formed by three mitochondrial DNA encoded subunits, Cox1, Cox2 and Cox3, conserved in the bacterial enzyme ...
Soto, Ileana C. +3 more
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Composition and function of cytochrome c biogenesis System II [PDF]
The FEBS Journal, 2011 Organisms employ one of several different enzyme systems to mature cytochromes c. The biosynthetic process involves the periplasmic reduction of cysteine residues in the heme c attachment motif of the apocytochrome, transmembrane transport of heme b and stereospecific covalent heme attachment via thioether bonds. The biogenesis System II (or Ccs system)
Jörg, Simon, Lars, Hederstedt
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In vitro studies on cytochrome c biogenesis [PDF]
, 2003 C-type cytochromes are essential for almost all organisms and are mainly involved in electron transport; they are characterised by the covalent attachment of heme to protein through two thioether bonds to a CXXCH peptide motif. This thesis describes the development of in vitro systems to establish chemical aspects of the process of cytochrome c ...
Daltrop, O, Daltrop, Oliver
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mBio, 2023 Heme trafficking is a fundamental biological process, yet its direct study has been hampered due to heme’s tight intracellular regulation, heme cytotoxicity, and the transient nature of trafficking.
Amber L. Grunow +3 more
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Reperfusion promotes mitochondrial biogenesis following focal cerebral ischemia in rats. [PDF]
PLoS ONE, 2014 BACKGROUND AND PURPOSE: Reperfusion after transient cerebral ischemia causes severe damage to mitochondria; however, little is known regarding the continuous change in mitochondrial biogenesis during reperfusion.
Yuying Xie +4 more
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Bacterial cytochromes c biogenesis. [PDF]
Genes & Development, 1992 We report the primary sequence analyses of two loci, hel and ccl, whose gene products are required specifically for the biogenesis of c-type cytochromes in the Gram-negative photosynthetic bacterium Rhodobacter capsulatus. Genetic and molecular analyses show that the hel locus contains at least four genes, helA, helB, helC, and orf52, and the ccl locus
D L, Beckman, D R, Trawick, R G, Kranz
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Brain Region Specificity of Mitochondrial Biogenesis and Bioenergetics Response to Nrf2 Knockdown: A Comparison Among Hippocampus, Prefrontal Cortex and Amygdala of Male Rat Brain [PDF]
Brazilian Archives of Biology and Technology, 2017 Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) has been identified as the well-known coordinator of intracellular antioxidant defense system. Herein, we aimed to evaluate the effects of Nrf2 silencing on mitochondrial biogenesis markers peroxisome ...
Solmaz Khalifeh +5 more
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Rcf1 Modulates Cytochrome c Oxidase Activity Especially Under Energy-Demanding Conditions
Frontiers in Physiology, 2020 The mitochondrial respiratory chain is assembled into supercomplexes. Previously, two respiratory supercomplex-associated proteins, Rcf1 and Rcf2, were identified in Saccharomyces cerevisiae, which were initially suggested to mediate supercomplex ...
Hannah Dawitz +5 more
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