Results 41 to 50 of about 19,855,151 (220)

Biochemical mapping reveals a conserved heme transport mechanism via CcmCD in System I bacterial cytochrome c biogenesis

mBio
Heme is a redox-active cofactor for essential processes across all domains of life. Heme’s redox capabilities are responsible for its biological significance but also make it highly cytotoxic, requiring tight intracellular regulation.
Alicia N. Kreiman, Sarah E. Garner, Susan C. Carroll, Molly C. Sutherland   +3 more
doaj   +1 more source

Upregulation of Mitochondrial Content in Cytochrome c Oxidase Deficient Fibroblasts. [PDF]

PLoS ONE, 2016
Cytochrome-c-oxidase (COX) deficiency is a frequent cause of mitochondrial disease and is associated with a wide spectrum of clinical phenotypes. We studied mitochondrial function and biogenesis in fibroblasts derived from the Cohen (CDs) rat, an animal ...
Aviram Kogot-Levin, Ann Saada, Gil Leibowitz, Devorah Soiferman, Liza Douiev, Itamar Raz, Sarah Weksler-Zangen   +6 more
doaj   +1 more source

Mitochondrial protein assemblies: Biogenesis of the cytochrome c oxidase and mitophagic signaling complexes [PDF]

, 2015
Mitochondrial physiology requires a constant balance between biosynthesis and degradation events. This thesis addresses both mitochondrial biogenesis, exemplified by cytochrome c oxidase assembly, and mitochondrial removal in the course of mitophagy ...
Levchenko, Mariia, Schwappach, Blanche, Rehling, Peter, Georg-August-Universität Göttingen, null null, Mariia Levchenko   +5 more
core   +1 more source

Perturbation of Cytochrome c Maturation Reveals Adaptability of the Respiratory Chain in Mycobacterium tuberculosis

mBio, 2013
Mycobacterium tuberculosis depends on aerobic respiration for growth and utilizes an aa3-type cytochrome c oxidase for terminal electron transfer. Cytochrome c maturation in bacteria requires covalent attachment of heme to apocytochrome c, which occurs ...
Jennifer L. Small, Sae Woong Park, Bavesh D. Kana, Thomas R. Ioerger, James C. Sacchettini, Sabine Ehrt   +5 more
doaj   +1 more source

Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.

PLoS ONE, 2011
Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR).
Fernanda M Cerqueira, Francisco R M Laurindo, Alicia J Kowaltowski   +2 more
doaj   +1 more source

Cytochrome c Oxidase Biogenesis and Metallochaperone Interactions: Steps in the Assembly Pathway of a Bacterial Complex. [PDF]

PLoS ONE, 2017
Biogenesis of mitochondrial cytochrome c oxidase (COX) is a complex process involving the coordinate expression and assembly of numerous subunits (SU) of dual genetic origin.
Sonja Schimo, Ilka Wittig, Klaas M Pos, Bernd Ludwig   +3 more
doaj   +1 more source

Resveratrol Improves Mitochondrial Biogenesis Function and Activates PGC-1α Pathway in a Preclinical Model of Early Brain Injury Following Subarachnoid Hemorrhage

Frontiers in Molecular Biosciences, 2021
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) has been shown to play a pivotal role in the regulation of mitochondrial biogenesis in diseases.
Jian Zhou, Zaijia Yang, Ruiming Shen, Wangwang Zhong, Huiduan Zheng, Zhenggang Chen, Jianjian Tang, Juan Zhu   +7 more
doaj   +1 more source

Cytochrome c biogenesis in bacteria

, 1998
Cytochromes c are electron transfer proteins in which haem is covalently attached to the polypeptide chain via thioether bonds formed from thiol groups of the two cysteines and the two vinyl groups of haem. This attachment is a post translational process and in many species of bacteria as many as approximately twelve gene products, the functions of ...
Sinha, N, Sinha, Neeti
openaire   +2 more sources

Cytochrome c oxidase biogenesis: New levels of regulation [PDF]

IUBMB Life, 2008
AbstractEukaryotic cytochrome c oxidase (COX), the last enzyme of the mitochondrial respiratory chain, is a multimeric enzyme of dual genetic origin, whose assembly is a complicated and highly regulated process. COX displays a concerted accumulation of its constitutive subunits. Data obtained from studies performed with yeast mutants indicate that most
Flavia, Fontanesi, Ileana C, Soto, Antoni, Barrientos   +2 more
openaire   +2 more sources

c-Type cytochrome biogenesis can occur via a natural Ccm system lacking CcmH, CcmG, and the heme-binding histidine of CcmE

, 2012
The Ccm cytochrome c maturation System I catalyzes covalent attachment of heme to apocytochromes c in many bacterial species and some mitochondria. A covalent, but transient, bond between heme and a conserved histidine in CcmE along with an interaction ...
Feng Rao (115532), Alan Goddard (17158585), Weelee Chan (17253865), Julie M. Stevens (1301319), David J. Richardson (632524), James W. A. Allen (17186398), Despoina A. I. Mavridou (8693736), Stuart J. Ferguson (160601)   +7 more
core   +4 more sources