Results 51 to 60 of about 19,855,151 (220)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

XC_0531 encodes a c-type cytochrome biogenesis protein and is required for pathogenesis in Xanthomonas campestris pv. campestris

BMC Microbiology, 2017
Background The phytopathogenic Xanthomonas campestris pv.campestris is a gram-negative bacterium and the causal agent of black-rot disease of cruciferous crops.
Lei Chen, Mingpeng Wang, Li Huang, Zhaojie Zhang, Fanghua Liu, Guangtao Lu   +5 more
doaj   +1 more source

The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1α signalling pathway

Adipocyte, 2020
The diabetes medication canagliflozin (Cana) is a sodium glucose cotransporter 2 (SGLT2) inhibitor acting by increasing urinary glucose excretion and thus reducing hyperglycaemia. Cana treatment also reduces body weight.
Xuping Yang, Qinhui Liu, Yanping Li, Qin Tang, Tong Wu, Lei Chen, Shiyun Pu, Yingnan Zhao, Guorong Zhang, Cuiyuan Huang, Jinhang Zhang, Zijing Zhang, Ya Huang, Min Zou, Xiongjie Shi, Wei Jiang, Rui Wang, Jinhan He   +17 more
doaj   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Mitochondrial cytochrome c oxidase biogenesis: Recent developments

Seminars in Cell & Developmental Biology, 2018
Mitochondrial cytochrome c oxidase (COX) is the primary site of cellular oxygen consumption and is essential for aerobic energy generation in the form of ATP. Human COX is a copper-heme A hetero-multimeric complex formed by 3 catalytic core subunits encoded in the mitochondrial DNA and 11 subunits encoded in the nuclear genome.
Timon-Gomez, A, Nyvltova, E, Abriata, LA, Vila, AJ, Hosler, J, Barrientos, A   +5 more
openaire   +5 more sources

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Analysis of putative heme ligands in the System I bacterial cytochrome c biogenesis heme transporter, CcmCD

Microbiology Spectrum
Heme is a key co-factor for biologically important proteins that are required for critical cellular functions such as oxygen transport and energy production.
Alicia N. Kreiman, Susan C. Carroll, Nikita P. Varde, Sarah E. Garner, Donna R. Price, Molly C. Sutherland   +5 more
doaj   +1 more source

Absence of Thiol-Disulfide Oxidoreductase DsbA Impairs cbb3-Type Cytochrome c Oxidase Biogenesis in Rhodobacter capsulatus

Frontiers in Microbiology, 2017
The thiol-disulfide oxidoreductase DsbA carries out oxidative folding of extra-cytoplasmic proteins by catalyzing the formation of intramolecular disulfide bonds. It has an important role in various cellular functions, including cell division. The purple
Ozlem Onder, Andreia F. Verissimo, Bahia Khalfaoui-Hassani, Annette Peters, Hans-Georg Koch, Fevzi Daldal   +5 more
doaj   +1 more source

Ornithine Lipid is Required for c‐type Cytochrome Biogenesis

The FASEB Journal, 2006
In phototrophic bacteria like Rhodobacter capsulatus (Rc), c‐type cytochrome (cyt) biogenesis is encoded by the ccmABCDEFGHI genes. Using the cyt cbb3 oxidase‐ phenotype, additional required genes were sought. This search yielded mutants that exhibited medium‐dependent photosynthetic growth, and that lacked various c‐type cyts ...
Goldfine, H, Aygun-Sunar, S, Mandaci, S, Daldal, F   +3 more
openaire   +2 more sources