Results 91 to 100 of about 203,240 (311)

Coordination Geometry Tuning in a Single‐Atom Nanozyme to Mimic Metalloenzymes with Nonplanar Active Site

Advanced Science, EarlyView.
Correlation between coordination geometry and catalytic activity of carbonic anhydrase‐mimetic single‐atom Zn–N4 active sites is revealed. Among tetrahedral, distorted tetrahedral, and square‐planar Zn–N4 geometric configurations, the distorted tetrahedral Zn–N4 exhibits superior CO2 hydrolysis performance. This is attributed to increased Lewis acidity,
Hyesung Lee, Changjoon Keum, Choah Kwon, Sangtae Kim, Youngdo Jeong, Sang‐Yup Lee   +5 more
wiley   +1 more source

A Needle‐Like H2S‐Releasing and H2O2 Self‐Replenishing Nanoplatform for Enhanced Chemodynamic Tumor Immunotherapy

Advanced Science, EarlyView.
The PTA‐SnS2@GOx cascade nanosystem presents a smart paradigm for cancer theranostics, integrating self‐supplied H2S/H2O2‐augmented chemodynamic therapy (CDT) with sensitized immunotherapy. Its needle‐like SnS2 shell enhances tumor‐specific uptake, ensuring biosafety.
Xiaoxiao Sun, Xia Zhang, Haiyan Qin, Lingling Li   +3 more
wiley   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

Cellular and Molecular Evidence of Acetaldehyde Elimination and Intracellular Environment Antioxidation by L-Cysteine

Journal of Chemistry, 2018
Acetaldehyde is a harmful metabolite of smoking and drinking. This study was initially intended to facilitate the understanding of the possible injury mechanism of A549 cells damaged by acetaldehyde and the possible protective mechanism of L-cysteine (L ...
Zhenjing Li, Xiaohong Zhang, Yibin Xue, Jingkai Zhang, Meiling Li, Cheng Luo   +5 more
doaj   +1 more source

Structural Re-arrangement and Peroxidase Activation of Cytochrome c by Anionic Analogues of Vitamin E, Tocopherol Succinate and Tocopherol Phosphate*

Journal of Biological Chemistry, 2014
Background: An anionic phospholipid, cardiolipin, converts cytochrome c into a peroxidase. Results: Anionic tocopherol derivatives, tocopherol succinate and tocopherol phosphate, similarly to cardiolipin, unfold cytpchrome c and stimulate its peroxidase ...
N. Yanamala, A. Kapralov, M. Djukic, J. Peterson, G. Mao, J. Klein-Seetharaman, D. Stoyanovsky, J. Štursa, J. Neuzil, V. Kagan   +9 more
semanticscholar   +1 more source

Application of docking method to assess the activity of hydrocarbonoclastic bacteria (HCB) from marine origin in bioremediation process

Squalen, 2010
Hydrocarbons are one of the main sources of acute and chronic stressors in marine environmentthat are potentially damaging the ecosystem if not properly overcame.
Ariyanti Suhita Dewi
doaj   +1 more source

Activation of Cytochrome C Peroxidase Function Through Coordinated Foldon Loop Dynamics upon Interaction with Anionic Lipids. [PDF]

J Mol Biol, 2021
Li M, Sun W, Tyurin VA, DeLucia M, Ahn J, Kagan VE, van der Wel PCA.   +6 more
europepmc   +1 more source

Cardiolipin Membranes Promote Cytochrome c Transformation of Polycyclic Aromatic Hydrocarbons and Their In Vivo Metabolites

Molecules
The catalytic properties of cytochrome c (Cc) have captured great interest in respect to mitochondrial physiology and apoptosis, and hold potential for novel enzymatic bioremediation systems.
João Lopes, Dorinda Marques-da-Silva, Paula A. Videira, Alejandro K. Samhan-Arias, Ricardo Lagoa   +4 more
doaj   +1 more source

Proteomic analysis reveals large amounts of decomposition enzymes and major metabolic pathways involved in algicidal process of Trametes versicolor F21a

Scientific Reports, 2017
A recent algicidal mode indicates that fungal mycelia can wrap and eliminate almost all co-cultivated algal cells within a short time span. However, the underlying molecular mechanism is rarely understood. We applied proteomic analysis to investigate the
Xueyan Gao, Congyan Wang, Wei Dai, Shenrong Ren, Fang Tao, Xingbing He, Guomin Han, Wei Wang   +7 more
doaj   +1 more source