Results 251 to 260 of about 203,240 (311)

1,8‐Cineole Protects Against Liver Toxicity Induced by Aroclor‐1254 in a Rat Model

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 8, August 2025.
This study aimed to determine the protective role of 1,8‐cineol in Aroclor‐1254 induced liver toxicity in a rat model. 1,8‐cineol may be a protective agent due to its anti‐apoptotic effect, reduction of oxidative damage, anti‐inflammatory efficacy, and amelioration of histopathological changes in liver toxicity. ABSTRACT This study aimed to demonstrate
Hadiqa Arshad, Muhammed Fatih Doğan, Münevver Nazlıcan Zengin, Özlem Özmen, Osman Çiftçi   +4 more
wiley   +1 more source

Mitochondria as Regulators of Nonapoptotic Cell Death in Cancer

MedComm, Volume 6, Issue 8, August 2025.
Mitochondrial fission and fusion are key processes in maintaining cellular health. Fission is driven by proteins like, Fis‐1, which recruits DRP‐1, to facilitate the division of mitochondria. Fusion, however, is mediated by mitofusion 1(MFN1), mitofusion 2(MFN2), and optic atrophy 1 (OPA1), which work together to merge mitochondria, allowing functional
Saloni Malla, Rabin Neupane, Saloni Sood, Noor Hussein, Mariam Abou‐Dahech, David Terrero, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +8 more
wiley   +1 more source

Polypharmacology‐Driven Discovery of ZAK‐I‐57: A Potent Multi‐Targeted Benzoxazinone Small Molecule for Hepatocellular Carcinoma Therapy

MedComm, Volume 6, Issue 8, August 2025.
ABSTRACT Hepatocellular carcinoma (HCC) is a deadly disease characterized by a high mortality rate and resistance to conventional therapies, highlighting the need for novel therapeutic interventions. Given the multifaceted nature of HCC pathogenesis, a multitargeted and polypharmacological approach is crucial for effective treatment. This study reports
Shakeel Ahmad Khan, Huihai Yang, Fan Ying, Chin Ngok Chu, Terence Kin Wah Lee   +4 more
wiley   +1 more source

Chemoprotective effect of nimbolide against N-methyl-N-nitrosourea induced gastric cancer via alteration of apoptosis and NF-κB signaling pathway. [PDF]

Acta Cir Bras
Gu Y, Liu B, Xia X, Luo C, Ren Y.
europepmc   +1 more source

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment

MedComm, Volume 6, Issue 8, August 2025.
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang, Ke Zhang, Zhenwang Zhang, Xinran Zeng, Zihang Huang, Peizhuo Qin, Zhilin Xie, Xue Cai, Milad Ashrafizadeh, Yu Tian, Ruqiong Wei   +10 more
wiley   +1 more source

Insights Into Atorvastatin Pharmacokinetics in Rats Reveal Regulation of CYP3A1 by Humanization of SLCO2B1

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT The organic anion transporting polypeptide (OATP) 2B1 is expressed in pharmacokinetically relevant organs such as the liver, the kidney, and the small intestine and it is known to transport a broad range of substrates including statins. In pharmacokinetic studies applying two rat models—one deficient for rat Oatp2b1 and the other expressing ...
Jonny Kinzi, Janine Hussner, Isabell Seibert, Marta Rysz, Valerio Taggi, Simone Zuercher, Annika Tillmann, Oliver Schwardt, Stefan Oswald, Daniel Ricklin, Henriette E. Meyer zu Schwabedissen   +10 more
wiley   +1 more source

Insights into Lead Toxicity and Detoxification Mechanisms in the Silkworm, <i>Bombyx mori</i>. [PDF]

Insects
Bian DD, Shi YX, Shi KW, Du HC, Tang BP, Liu QN.   +5 more
europepmc   +1 more source

Mangiferin Against Respiratory Diseases: Pharmacological Targets and Prospects

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Respiratory diseases are associated with high mortality worldwide. Respiratory infections can lead to the emergence of chronic respiratory diseases. Scientists are constantly striving to identify new therapies with reduced side effects.
Kazi Ahsan Ahmed, Nusrat Afrin, Popy Ghosh, Irin Amin Heya, Sajidur Rahman Akash, Akhi Moni, Mohammad Nazrul Islam, Md. Golzar Hossain, Alessandra Sinopoli, Md Abdul Hannan, Md Jamal Uddin   +10 more
wiley   +1 more source

Antioxidant, Antiinflammatory and Antiapoptotic Effects of Lycopene in Rats With Vancomycin‐Induced Nephrotoxicity

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 2, August 2025.
Vancomycin caused nephrotoxicity in rats. Lycopene treatment showed ameliorative efficacy on vancomycin‐induced nephrotoxicity. This efficacy of lycopene was dose dependent. ABSTRACT Background The most important side effect of vancomycin (Vanco) is nephrotoxicity (NPT).
Hülya Demirkapı Atik, Orkun Atik, Recep Aslan, Yavuz Osman Birdane, Abdullah Eryavuz   +4 more
wiley   +1 more source

Nanozymes expanding the boundaries of biocatalysis. [PDF]

Nat Commun
Zhang R, Yan X, Gao L, Fan K.
europepmc   +1 more source