Results 31 to 40 of about 203,240 (311)

Dually Cross-Linked Core-Shell Structure Nanohydrogel with Redox–Responsive Degradability for Intracellular Delivery

Pharmaceutics, 2021
A redox-responsive nanocarrier is a promising strategy for the intracellular drug release because it protects the payload, prevents its undesirable leakage during extracellular transport, and favors site-specific drug delivery.
Siyuan Deng, Maria Rosa Gigliobianco, Emin Mijit, Marco Minicucci, Manuela Cortese, Barbara Campisi, Dario Voinovich, Michela Battistelli, Sara Salucci, Pietro Gobbi, Giulio Lupidi, Giorgia Zambito, Laura Mezzanotte, Roberta Censi, Piera Di Martino   +14 more
doaj   +1 more source

Use of in-gel peroxidase assay for cytochrome c to visualize mitochondrial complexes III and IV

Biology Open, 2020
The in-gel activity assay (IGA) is a powerful technique that uses enzymatic activity and compares intensities of detected bands in mitochondrial respiratory chain supercomplexes, and it is applicable to eukaryotic organisms.
Tsukasa Hara, Yuma Shibata, Ryosuke Amagai, Ayako Okado-Matsumoto   +3 more
doaj   +1 more source

Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle

Nature Communications, 2023
Skeletal muscle is more resilient to ischemia-reperfusion injury than other organs. Tissue specific post-translational modifications of cytochrome c (Cytc) are involved in ischemia-reperfusion injury by regulating mitochondrial respiration and apoptosis.
Paul T. Morse, Gonzalo Pérez-Mejías, Junmei Wan, Alice A. Turner, Inmaculada Márquez, Hasini A. Kalpage, Asmita Vaishnav, Matthew P. Zurek, Philipp P. Huettemann, Katherine Kim, Tasnim Arroum, Miguel A. De la Rosa, Dipanwita Dutta Chowdhury, Icksoo Lee, Joseph S. Brunzelle, Thomas H. Sanderson, Moh H. Malek, David Meierhofer, Brian F. P. Edwards, Irene Díaz-Moreno, Maik Hüttemann   +20 more
doaj   +1 more source

The Naturally Occurring A51V Variant of Human Cytochrome c Destabilizes the Native State and Enhances Peroxidase Activity.

Journal of Physical Chemistry B, 2019
The A51V variant of human cytochrome c is linked to thrombocytopenia 4 (THC4), a condition that causes decreased blood platelet counts. A 1.82 Å structure of the A51V variant shows only minor changes in tertiary structure relative to the wild type (WT ...
Haotian Lei, B. Bowler
semanticscholar   +1 more source

Hydrogen-rich water treatment improves fresh-cut Gastrodia elata quality by regulating reactive oxygen species metabolism and energy metabolism during low temperature storage

Frontiers in Sustainable Food Systems, 2023
The application of hydrogen-rich water (HRW) can extend the shelf life of fruits and vegetables. This study aims to investigate the effects of HRW on the quality of fresh-cut Gastrodia elata during low-temperature (4°C) storage. The results indicate that
Boyu Dong, Boyu Dong, Dequan Zhu, Dequan Zhu, Qiuping Yao, Qiuping Yao, Fangfang Da, Fangfang Da, Yulong Chen, Yulong Chen, Xiaochun Ding   +10 more
doaj   +1 more source

Effects of Laser Radiation on Mitochondria and Mitochondrial Proteins Subjected to Nitric Oxide

Frontiers in Medicine, 2018
The biological roles of heme and nonheme nitrosyl complexes in physiological and pathophysiological conditions as metabolic key players are considered in this study. Two main physiological functions of protein nitrosyl complexes are discussed—(1) a depot
Anatoly N. Osipov, Tatiana V. Machneva, Evgeny A. Buravlev, Evgeny A. Buravlev, Yury A. Vladimirov, Yury A. Vladimirov   +5 more
doaj   +1 more source

Acute Alcohol Tissue Damage: Protective Properties of Betaine

Journal of Renal and Hepatic Disorders, 2021
Teenage binge drinking is a major health issue; however, there is a paucity of data on liver injury. Herein, we investigated how acute ethanol affects juvenile hepatic cells through changes in oxidative stress, apoptosis, and liver function, as well as ...
Lucy Petagine, Hannah Everitt, Victor Preedy, Roy Sherwood, Vinood Patel   +4 more
doaj   +1 more source

The complex of cytochrome c and cytochrome c peroxidase: The end of the road?

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2011
Cytochrome c (Cc) and cytochrome c peroxidase (CcP) form a physiological complex in the inter-membrane space of yeast mitochondria, where CcP reduces hydrogen peroxide to water using the electrons provided by ferrous Cc. The Cc-CcP system has been a popular choice of study of interprotein biological electron transfer (ET) and in understanding dynamics ...
Volkov, A.N., Worrall, J.A.R., Nicholls, P.   +2 more
openaire   +4 more sources

Lysine carbonylation is a previously unrecognized contributor to peroxidase activation of cytochrome c by chloramine-T

Chemical Science, 2019
Ion mobility-assisted tandem MS uncovers hitherto overlooked modifications that are critical for the peroxidase activity of chloramine T-modified cytochrome c.
Victor C Yin, Safee Mian, L. Konermann
semanticscholar   +1 more source

Lysine 53 Acetylation of Cytochrome c in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis

Cells, 2021
Prostate cancer is the second leading cause of cancer-related death in men. Two classic cancer hallmarks are a metabolic switch from oxidative phosphorylation (OxPhos) to glycolysis, known as the Warburg effect, and resistance to cell death. Cytochrome c
Viktoriia Bazylianska, Hasini A. Kalpage, Junmei Wan, Asmita Vaishnav, Gargi Mahapatra, Alice A. Turner, Dipanwita Dutta Chowdhury, Katherine Kim, Paul T. Morse, Icksoo Lee, Joseph S. Brunzelle, Lisa Polin, Prabal Subedi, Elisabeth I. Heath, Izabela Podgorski, Katrin Marcus, Brian F.P. Edwards, Maik Hüttemann   +17 more
doaj   +1 more source