Results 81 to 90 of about 203,240 (311)

Spatial Coordination Structure‐Driven Enzyme‐Like Selectivity in Single‐Atom Nanozymes

Advanced Materials, EarlyView.
Sun et al. reviews recent progress in enhancing the enzyme‐like catalytic selectivity of SAzymes through the rational design of their spatial coordination structures. They emphasize the structure‐activity relationships of various attributes of these coordination structures in promoting selective catalytic behavior, the strategic design of coordination ...
Qijun Sun, Si Liu, Ziping Li, Peiji Deng, Na Niu, Ligang Chen, Kang Liang   +6 more
wiley   +1 more source

Metabolic Engineering of the 5‐Aminolevulinate Biosynthetic Pathway in E. coli Improves Efficiency of Hemoprotein‐Based Biocatalysis

Angewandte Chemie, EarlyView.
We have engineered the heme biosynthetic pathway in E. coli to develop an efficient cofactor supplementation system for hemoproteins. Through the incorporation of the heterogeneous C4 pathway, the engineered cells significantly increase the expression levels of active holohemoproteins and enhance the efficiency of whole‐cell and lysate‐based ...
Shunsuke Kato, Miteki Abe, Nobuyuki Okahashi, Shinya Ariyasu, Fumio Matsuda, Osami Shoji, Takashi Hayashi   +6 more
wiley   +2 more sources

Cytochrome c Peroxidase–Cytochrome c Complexes

, 2015
The yeast cytochrome c peroxidase (CCP)–cytochrome c (cytc) electron transfer system has been critically important in deciphering the molecular level details of protein–protein interactions and electron transfer. The crystal structure of the CCP–cytc together with a number mutagenesis, enzymological, and spectroscopic studies have provided a detailed ...
openaire   +3 more sources

Automated Transcranial Photobiomodulation in Healthy Rats: Effects on Working Memory and Brain Markers

Advanced Therapeutics, EarlyView.
Transcranial photobiomodulation (PBM) enhances spatial working memory in healthy rats under both continuous and alternating stimulation protocols. At the neural level, PBM modulates cytochrome c oxidase activity, increases prefrontal and hippocampal synaptic markers, and induces region‐specific c‐Fos expression. These effects suggest improved cognitive
Candela Zorzo, Lucía Rodríguez‐Fernández, Emily Gabriela Castillo‐Escalona, Juan A. Martínez, Laura Mañas, Natalia Arias, Jorge L. Arias   +6 more
wiley   +1 more source

An Apple Susceptibility‐Related LRR Receptor‐Like Kinase MdRLKT21 Activates Plant Immunity by Hijacking a Trans‐Kingdom Fungal microRNA‐Like RNA

Advanced Science, EarlyView.
The apple susceptibility‐related LRR‐RLK MdRLKT21 competitively binds to fungal sRNA effectors and subsequently activates defenses by salvaging the expression of MdRLKT1 and MdRLKT2 and thereby releasing the resistance protein MdRFP1. These findings provide new insights into the molecular mechanism by which plants counteract pathogen‐secreted sRNA ...
Mingliang Lei, Jian Zhang, Jie Wang, Chengyu Gao, Yanting He, Runze Tian, Hao Feng, Lili Huang   +7 more
wiley   +1 more source

Electron transfer between cytochrome c and cytochome c peroxidase in single crystals.

Journal of the American Chemical Society, 2004
Cytochrome c (Cc) and cytochrome c peroxidase (CcP) form an important redox pair for understanding interprotein electron transfer (ET). Measurements of ET rates from photoexcited CcP substituted with Zn porphyrin to either yeast Fe(III)Cc or horse Fe(III)
Seong A. Kang, Pieti Marjavaara, B. Crane   +2 more
semanticscholar   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

Oxidative and apoptotic effects of fluoxetine and its metabolite norfluoxetine in Daphnia magna

Arhiv za Higijenu Rada i Toksikologiju, 2020
The aim of this study was to investigate the oxidative and apoptotic potential of fluoxetine, a widely used antidepressant in Turkey and the world, and of its metabolite norfluoxetine on a model non-target organism, Daphnia magna to see how exposure to ...
Över Sevgi Başalan, Güven Celal, Taskin Eylem, Sevgiler Yusuf   +3 more
doaj   +1 more source

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

Advanced Science, EarlyView.
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu, Lin Jing, Yixin Li, Jinxing Zhou, Xiaohui Cui, Sen Li, Shijie Yang, Fangming Kan, Junfeng Du, Wentao Zhong, Sheng Yu, Ning Wang, Xing Jia, Junhui Li, Pan Nie, Zhenzhong Chen, Ying Han, Lingxi Jiang, Xiyun Yan, Hongxia Duan, Baiyong Shen   +20 more
wiley   +1 more source

Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome.

Nature Metabolism, 2023
Valerian E Kagan, Y. Tyurina, K. Mikulska-Ruminska, Deena Damschroder, Eduardo Vieira Neto, Alessia Lasorsa, A. Kapralov, V. Tyurin, A. Amoscato, S. Samovich, Austin B. Souryavong, H. Dar, Abu Ramim, Zhuqing Liang, Pablo Lazcano, J. Ji, Michael W. Schmidtke, K. Kiselyov, Aybike Korkmaz, G. K. Vladimirov, M. Artyukhova, Pushpa Rampratap, L. Cole, Ammanamanchi Niyatie, Emma-Kate Baker, Jim Peterson, Grant M. Hatch, Jeffrey Atkinson, Jerry Vockley, Bernhard Kühn, R. Wessells, P. V. D. van der Wel, Ivet Bahar, H. Bayır, M. Greenberg   +34 more
semanticscholar   +1 more source