Results 101 to 110 of about 778,750 (338)

Import of cytochrome c into mitochondria [PDF]

, 1989
The covalent attachment of heme to apocytochrome c, and therefore the import of cytochrome c into mitochondria, is dependent on both NADH plus a cytosolic cofactor that has been identified to be FMN or FAD.
Neupert, Walter, Nicholson, Donald W.
core  

Different Transport Pathways of Individual Precursor Proteins in Mitochondria [PDF]

, 1981
Transport of mitochondrial precursor proteins into mitochondria of Neurospora crassa was studied in a cellfree reconstituted system. Precursors were synthesized in a reticulocyte lysate programmed with Neurospora mRNA and transported into isolated ...
Allen E. H., Ambler R. P., Basile G., Conboy J. G., Cote C., Fisher W. R., Hackenberg H., Hallermayer G., Harmey M. A., Heller J., Jagow G., Korb H., Laemmli U. K., Lewin A., Maccechini M. -L., Maccechini M. -L., Michel R., Mihara K., Mori M., Nelson N, Paul K. G., Pelham H. R. B., Raymond Y., Schatz G., Schmelzer E., Sebald W., Shore G. S., Sonderegger P., Tzagoloff A., Zimmermann R., Zimmermann R., Zimmermann R.   +31 more
core   +1 more source

Bioinspired Design of Heterogenous Single‐Atomic‐Site Catalysts for Electrocatalysis and Photocatalysis

Advanced Materials, EarlyView.
This review gives a summary on the representative bioinspired single‐atomic‐site catalysts (SACs) and their applications in heterogeneous electrocatalysis and photocatalysis. The fundamentals of bioinspired design strategies are systematically discussed in the context of the first shell coordination, the second/long‐range coordination, and the outer ...
Ying Wang, Guangri Jia, Piaoping Yang, Linshan Zhang, Kwok‐Yin Wong   +4 more
wiley   +1 more source

MOM19, an import receptor for mitochondrial precursor proteins [PDF]

, 1989
We have identified a 19 kd protein of the mitochondrial outer membrane (MOM19). Monospecific IgG and Fab fragments directed against MOM19 inhibit import of precursor proteins destined for the various mitochondrial subcompartments, including porin ...
Griffiths, Gareth, Neupert, Walter, Pfaller, Rupert, Pfanner, Nikolaus, Söllner, Thomas   +4 more
core   +1 more source

Development of Photo‐Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten

Advanced Synthesis &Catalysis, EarlyView.
Abstract α‐Chiral amines are versatile building blocks for the asymmetric synthesis of optically pure high‐added‐value chemicals, including pharmaceuticals, agrochemicals, and natural products. Herein, we report a one‐pot, two‐step sequential deracemization of racemic sec‐alcohols to optically enriched primary amines throught a photo‐biocatalytic ...
Natalia Antos, Aleksandra Rudzka, Anna Hoser, Tamara Reiter, Wolfgang Kroutil, Paweł Borowiecki   +5 more
wiley   +1 more source

Automated Transcranial Photobiomodulation in Healthy Rats: Effects on Working Memory and Brain Markers

Advanced Therapeutics, EarlyView.
Transcranial photobiomodulation (PBM) enhances spatial working memory in healthy rats under both continuous and alternating stimulation protocols. At the neural level, PBM modulates cytochrome c oxidase activity, increases prefrontal and hippocampal synaptic markers, and induces region‐specific c‐Fos expression. These effects suggest improved cognitive
Candela Zorzo, Lucía Rodríguez‐Fernández, Emily Gabriela Castillo‐Escalona, Juan A. Martínez, Laura Mañas, Natalia Arias, Jorge L. Arias   +6 more
wiley   +1 more source

Physiological function and catalytic versatility of bacterial multihaem cytochromescinvolved in nitrogen and sulfur cycling [PDF]

, 2011
Bacterial MCCs (multihaem cytochromes c) represent widespread respiratory electron-transfer proteins. In addition, some of them convert substrates such as nitrite, hydroxylamine, nitric oxide, hydrazine, sulfite, thiosulfate or hydrogen peroxide. In many
Arslan, Atkinson, Bayachou, Bianca Hermann, Campbell, Clarke, Costa, de Almeida, Eaves, Einsle, Einsle, Frawley, Hartshorne, Hartshorne, Henson, Hoffmann, Igarashi, Julea N. Butt, Jörg Simon, Kemp, Kern, Kern, Kern, Kern, Kern, Klotz, Kostera, Kostera, Kranz, Londer, Lukat, Marritt, Melanie Kern, Mills, Mowat, Mowat, Oliver Einsle, Pereira, Pisa, Pittman, Poock, Rudolf, Schalk, Sharma, Shimamura, Shimamura, Shirodkar, Simon, Simon, Simon, Sorokin, Stach, Strous, Tikhonova, van Wonderen   +54 more
core   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Solanidine-derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients. [PDF]

Br J Clin Pharmacol
Abstract Aims Phenoconversion, a genotype‐phenotype mismatch, challenges a successful implementation of personalized medicine. The aim of this study was to detect and determine phenoconversion using the solanidine metabolites 3,4‐seco‐solanidine‐3,4‐dioic acid (SSDA) and 4‐OH‐solanidine as diet‐derived cytochrome P450 2D6 (CYP2D6) biomarkers in a ...
Sarömba JA, Müller JP, Tupiec J, Roeth A, Kurt B, Kahles F, Laurentius T, Bollheimer C, Stingl JC, Just KS.   +9 more
europepmc   +2 more sources

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source