Haplotype network analyses, genetic diversity, and population structure of Hyalomma anatolicum based on cytochrome c oxidase subunit I (COI) and the large subunit ribosomal RNA (16S rRNA). [PDF]
Khan Z +7 more
europepmc +1 more source
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
Protocols for monitoring condensate formation and dynamics between the phase-separating proteins SET/TAF-Iβ and cytochrome c. [PDF]
Casado-Combreras MÁ +2 more
europepmc +1 more source
Abstract Aim Tacrolimus dosing in the early post‐kidney transplant period is challenging due to a narrow therapeutic index and substantial interindividual pharmacokinetic (PK) variability. This study aimed to develop and validate mechanism‐informed machine learning (ML) models to support individualized tacrolimus dosing during this critical period ...
Hui Yu +4 more
wiley +1 more source
Effects of marijuana and tobacco on male fertility and their relationship to genetic variation of mitochondrial cytochrome C oxidase genes. [PDF]
Amor H +6 more
europepmc +1 more source
Abstract Aim Tacrolimus monitoring is generally performed in whole blood (WB). Most (>85%) of circulating tacrolimus is bound to red blood cells. During pregnancy, WB monitoring might be suboptimal because of physiological changes including increased plasma volume and decreased haematocrit.
Jildau R. Meinderts +7 more
wiley +1 more source
A Case of Infantile Reversible Cytochrome C Oxidase Deficiency Myopathy in Taiwan: A 4-Year Follow-Up. [PDF]
Ma YT +4 more
europepmc +1 more source
Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells
Common genetic CYP2B6 variants correlate with adverse breast cancer outcome. The oestrogen metabolites estriol and 16‐epiestriol, which are formed downstream of CYP2B6‐catalysed 16α/β‐hydroxytestosterone, may be linked to elevated breast cancer risk and might increase due to the demonstrated CYP2B6 variants‐related metabolic shifts.
Marco Hoffmann +5 more
wiley +1 more source

