Results 61 to 70 of about 20,306,851 (378)

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Import of apocytochrome c into the mitochondrial intermembrane space along a cytochrome c1 sorting pathway [PDF]

, 1990
The question of whether cytochrome c could be functionally sorted to the mitochondrial intermembrane space along a "conservative sorting" pathway was investigated using a fusion protein termed pLc1-c. pLc1-c contains 3-fold targeting information, namely,
Neupert, Walter, Nicholson, Donald W., Stuart, Rosemary A., Wienhues, Ulla   +3 more
core  

A Structural Model of the Cytochrome c Reductase/Oxidase Supercomplex from Yeast Mitochondria [PDF]

, 2007
Mitochondrial respiratory chain complexes are arranged in supercomplexes within the inner membrane. Interaction of cytochrome c reductase (complex III) and cytochrome c oxidase (complex IV) was investigated in Saccharomyces cerevisiae. Projection maps at
Allen, Berry, Boumans, Cruciat, DeLano, Dudkina, Dudkina, Dudkina, Dudkina, Giraud, Guex, Harris, Heinemeyer, Khalimonchuk, Kim, Lange, Lee, Ludtke, Mannella, Meisinger, Minauro-Sanmiguel, Neuhoff, Paumard, Pearce, Penczek, Pfeiffer, Roberts, Saraste, Schwerzmann, Schäfer, Schägger, Schägger, Schägger, Schägger, Stroh, Sunderhaus, Tsukihara, Van Heel, Van Heel, Wittig, Wittig, Zerbetto, Zhang, Zhang   +43 more
core   +4 more sources

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

Journal of Cell Biology, 1999
Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol, cytochrome c binds to the CED-4 homologue, Apaf-1, thereby triggering Apaf-1–mediated activation of caspase-9.
E. Slee, M. Harte, R. Kluck, B. Wolf, C. Casiano, D. Newmeyer, Hong-Gang Wang, John Calvin Reed, D. Nicholson, E. Alnemri, D. Green, Seamus J. Martin   +11 more
semanticscholar   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Long-Wavelength Infrared Sensing by Cytochrome C Protein Thin Film Deposited by the Spin Coating Method

Sensors, 2013
High infrared absorption, large temperature coefficient of resistance (TCR) and small 1/f noise are preferred characteristics for sensing materials used in bolometers. In this paper, we discuss a cytochrome c protein as a potential sensing material for
Bo-Yu Lai, Chung-Hao Chu, Guo-Dung John Su   +2 more
doaj   +1 more source

Cytochrome c-554 from Methylosinus trichosporium OB3b; a protein that belongs to the cytochrome c2 family and exhibits a HALS-Type EPR signal. [PDF]

PLoS ONE, 2011
A small soluble cytochrome c-554 purified from Methylosinus trichosporium OB3b has been purified and analyzed by amino acid sequencing, mass spectrometry, visible, CD and EPR spectroscopies.
Espen Harbitz, K Kristoffer Andersson
doaj   +1 more source

Cell-free synthesis of cytochrome c [PDF]

, 1979
Cytochrome c is a peripheral membrane protein, attached to the cytoplasmic surface of the inner mito-chondrial membrane [l-4].
Blombäck, Cassio, Chance, De Pierre, Dubnoff, Estabrook, Fisher, Gonzales-Cadavid, Hackenbrock, Hallermayer, Harmey, Heller, Korb, Lederer, Lodish, Palmiter, Richard Zimmermann, Schatz, Scheele, Sebald, Sherman, Smith, Stewart, Strauss, Ulrich Paluch, Walter Neupert, Zimmermann, Zitomer   +27 more
core   +1 more source

The interactions of cytochrome c and porphyrin cytochrome c with cytochrome c oxidase. The resting, reduced and pulsed enzymes [PDF]

European Journal of Biochemistry, 1986
Cytochrome c oxidase forms tight binding complexes with the cytochrome c analog, porphyrin cytochrome c. The behaviour of the reduced and pulsed forms of the oxidase with porphyrin cytochrome c have been followed as functions of ionic strength; this behaviour has been compared with that of the resting oxidase [Kornblatt, Hui Bon Hoa and English (1984 ...
Hue Anh Luu, Jack A. Kornblatt
openaire   +3 more sources

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source