Results 61 to 70 of about 40,950,057 (342)

Molecular dynamics simulations and hydrogen-bonded network dynamics of cytochrome c oxidase from Paracoccus denitrificans [PDF]

, 2004
Cytochrome c oxidase is the terminal enzyme in the respiratory chain of mitochondria and aerobic bacteria. This enzyme ultimately couples electron transfer from cytochrome c to an oxygen molecule with proton translocation across the inner mitochondrial ...
Olkhova, E., Olkhova, Elena
core  

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Cytochrome c as a Potentially Clinical Useful Marker of Mitochondrial and Cellular Damage

Frontiers in Immunology, 2016
Mitochondria are evolutionary endosymbionts derived from bacteria. Thus, they bear molecules, such as mitochondrial DNA (mtDNA) that contains CpG DNA repeats and N-formyl peptides (FPs), found in bacteria. Upon cell necrosis or apoptosis, these molecules
T. Eleftheriadis, G. Pissas, V. Liakopoulos, I. Stefanidis   +3 more
semanticscholar   +1 more source

The complex of cytochrome c and cytochrome c peroxidase: The end of the road?

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2011
Cytochrome c (Cc) and cytochrome c peroxidase (CcP) form a physiological complex in the inter-membrane space of yeast mitochondria, where CcP reduces hydrogen peroxide to water using the electrons provided by ferrous Cc. The Cc-CcP system has been a popular choice of study of interprotein biological electron transfer (ET) and in understanding dynamics ...
Volkov, A.N., Worrall, J.A.R., Nicholls, P.   +2 more
openaire   +3 more sources

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Structural Insights into Mechanisms Underlying Mitochondrial and Bacterial Cytochrome c Synthases

Biomolecules
Mitochondrial holocytochrome c synthase (HCCS) is an essential protein in assembling cytochrome c (cyt c) of the electron transport system. HCCS binds heme and covalently attaches the two vinyls of heme to two cysteine thiols of the cyt c CXXCH motif ...
Pema L. Childs, Ethan P. Lowder, Deanna L. Mendez, Shalon E. Babbitt, Amidala Martinie, Jonathan Q. Huynh, Robert G. Kranz   +6 more
doaj   +1 more source

Mitochondrial Cytochrome c Oxidase Deficiency

Clinical science, 2016
As with other mitochondrial respiratory chain components, marked clinical and genetic heterogeneity is observed in patients with a cytochrome c oxidase deficiency.
Malgorzata Rak, P. Bénit, D. Chrétien, Juliette Bouchereau, M. Schiff, R. El-Khoury, A. Tzagoloff, P. Rustin   +7 more
semanticscholar   +1 more source

Evolution of the Couple Cytochrome c and Cytochrome c Oxidase in Primates [PDF]

, 2012
Mitochondrial energy metabolism has been affected by a broad set of ancient and recent evolutionary events. The oldest example is the endosymbiosis theory that led to mitochondria and a recently proposed example is adaptation to cold climate by anatomically modern human lineages.
Denis, Pierron, Derek E, Wildman, Maik, Hüttemann, Thierry, Letellier, Lawrence I, Grossman   +4 more
openaire   +2 more sources

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Complex structure of cytochrome c–cytochrome c oxidase reveals a novel protein–protein interaction mode

EMBO Journal, 2016
Mitochondrial cytochrome c oxidase (CcO) transfers electrons from cytochrome c (Cyt.c) to O2 to generate H2O, a process coupled to proton pumping. To elucidate the mechanism of electron transfer, we determined the structure of the mammalian Cyt.c–CcO ...
S. Shimada, K. Shinzawa-Itoh, J. Baba, Shimpei Aoe, A. Shimada, E. Yamashita, Jiyoung Kang, M. Tateno, S. Yoshikawa, T. Tsukihara   +9 more
semanticscholar   +1 more source