Copper-Induced Enhancement of Glioblastoma Tumorigenicity via Cytochrome C Oxidase [PDF]
AntioxidantsCopper is an essential trace element, yet chronic copper exposure can lead to toxicity in humans, and high levels of copper have been found in the blood or tumors of patients with various forms of cancer and may affect cancer severity and response to ...
Claudia R. Oliva +3 more
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Thermodynamic Volume Cycles for Electron Transfer in the Cytochrome c Oxidase and for the Binding of Cytochrome c to Cytochrome c Oxidase [PDF]
Biophysical Journal, 1998 Dilatometry is a sensitive technique for measuring volume changes occurring during a chemical reaction. We applied it to the reduction-oxidation cycle of cytochrome c oxidase, and to the binding of cytochrome c to the oxidase. We measured the volume changes that occur during the interconversion of oxidase intermediates.
Kornblatt, Jack A. +4 more
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Cell Reports, 2019 Summary: In eukaryotes, cellular respiration is driven by mitochondrial cytochrome c oxidase (CcO), an enzyme complex that requires copper cofactors for its catalytic activity.
Marcos N Morgada +2 more
exaly +3 more sources
Evolution of a biological thermocouple by adaptation of cytochrome c oxidase in a subterrestrial metazoan, Halicephalobus mephisto [PDF]
Communications BiologyIn this study, we report a biological temperature-sensing electrical regulator in the cytochrome c oxidase of the Devil Worm, Halicephalobus mephisto.
Megan N. Guerin +10 more
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Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase
Cells, 2021 Cytochrome c oxidase (COX), the rate-limiting enzyme of mitochondrial respiration, is regulated by various mechanisms. Its regulation by ATP (adenosine triphosphate) appears of particular importance, since it evolved early during evolution and is still ...
Rabia Ramzan +2 more
doaj +1 more source
Nature Communications, 2021 Cytochrome c oxidase is a fundamental enzyme of life and its mechanism is not fully understood yet. Here, the authors present four cryo-EM structures of different intermediate states, which suggest an alternative cytochrome c oxidase reaction cycle.
F. Kolbe +5 more
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Rcf1 Modulates Cytochrome c Oxidase Activity Especially Under Energy-Demanding Conditions
Frontiers in Physiology, 2020 The mitochondrial respiratory chain is assembled into supercomplexes. Previously, two respiratory supercomplex-associated proteins, Rcf1 and Rcf2, were identified in Saccharomyces cerevisiae, which were initially suggested to mediate supercomplex ...
Hannah Dawitz +5 more
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Multilayered polyelectrolyte microcapsules: interaction with the enzyme cytochrome C oxidase. [PDF]
PLoS ONE, 2014 Cell-sized polyelectrolyte capsules functionalized with a redox-driven proton pump protein were assembled for the first time. The interaction of polyelectrolyte microcapsules, fabricated by electrostatic layer-by-layer assembly, with cytochrome c oxidase
Laura Pastorino +9 more
doaj +1 more source
Activity of respiratory chain cytochrome complexes and cytochromes content in the rat kidney mitochondria under different nutrients content in a diet [PDF]
The Ukrainian Biochemical Journal, 2023 An important role in ensuring the functioning of the respiratory chain belongs to the cytochrome part, which includes complexes III (ubiquinol-cytochrome c oxidoreductase) and IV (cytochrome c oxidase). The key components of these enzymatic complexes are
H. P. Kopylchuk, O. M. Voloshchuk
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Cytochrome c Oxidase Deficiency [PDF]
Pediatric Research, 1990 Cytochrome c oxidase (COX) is a complex enzyme composed of 13 subunits, three of which are encoded by the mitochondrial DNA (mtDNA). The other 10 subunits are encoded by the nuclear DNA, synthesized in the cytoplasm, and transported into the mitochondria.
Dlmauro S. +9 more
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