Results 111 to 120 of about 28,268,520 (143)

Evaluation of the Effect of Cendakimab on the Pharmacokinetics of CYP Probe Drugs in Patients With Eosinophilic Esophagitis. [PDF]

Clin Transl Sci
Zhang P, Charriez CM, Murthy B, Basdeo S, Wang Y, Villa-Caballero L, Kandoussi H, De Oliveira CHMC, Leiman DA, Li J, Aras U.   +10 more
europepmc   +1 more source

DeepCYP: an integrated deep learning web server for the holistic "pathway-site product" prediction of CYP450 metabolism. [PDF]

Nucleic Acids Res
Zhou Y, Yang S, Wang X, He Y, Tian Y, Yi J, Wang Y, Deng Y, Jiang D, Cao D.   +9 more
europepmc   +1 more source

Herbal Medicines and Drugs Interactions: Cytochrome P450 Responsibility. [PDF]

Curr Med Chem
Shanaida M, Oleshchuk O, Shevchuk O, Posokhova K, Ivankiv Y, Mocherniuk K, Klantsa M, Korda M.   +7 more
europepmc   +1 more source

Integrated genomic, transcriptomic, and microsomal metabolic profiling of cytochrome P450s in squirrels. [PDF]

J Vet Med Sci
Goto M, Watanabe K, Yohannes YB, Hasegawa N, Morita A, Banda N, Kakisaka K, Ito M, Ikenaka Y, Nakayama SM, Ishizuka M.   +10 more
europepmc   +1 more source

Dexamethasone-Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH-7 Cells. [PDF]

Fundam Clin Pharmacol
Yu H, Lee SH, Kim JH, Kim SJ, Kang HE.
europepmc   +1 more source

Unraveling the complexities of caffeine: metabolism, genetics, evolution, and health. [PDF]

Hereditas
Liu X, Xu S.
europepmc   +1 more source

Fused Azine Derivatives Mitigate Long-Term Paracetamol-Induced Liver Fibrosis in Mice: Role of JNK1/ASK1 and Nrf2/HO-1 Signaling Pathways. [PDF]

Inflammation
Shawky AR, Metwaly HA, Ragab HM, Wahid A.   +3 more
europepmc   +1 more source

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Regulation of Cytochrome P-450 Isozymes CYP1A1, CYP1A2 and CYP2B10 by Three Benzodioxole Compounds

Chemico-Biological Interactions, 1995
Three benzodioxole (BD) compounds were used to investigate the structural requirement for regulation of the cytochrome P450 isozymes, CYP1A1, CYP1A2 and CYP2B10, in mouse liver. Male mice (C57BL/6) were treated intraperitoneally for 3 days with 5-t-butyl-1,3-benzodioxole (t-BBD), 5-n-butyl-1,3-benzodioxole (n-BBD) and 5-(3-oxobutyl)-1,3-benzodioxole (o-
E Hodgson, Patricia E Levi, P E Levi
exaly   +3 more sources

Comparison of Levels of Cytochromes P-450, CYP1A2, CYP2E1, and Their Related Monooxygenase Activities in Human Surgical Liver Samples

Alcoholism: Clinical and Experimental Research, 1993
Hepatic microsomal cytochromes P‐450 CYP1A2, and CYP2E1 contents and catalytic activities have been simultaneously investigated in 42 patients undergoing diagnostic liver biopsy. CYP1A2 contents, measured by Western blotting, were correlated with methoxyresorufin‐O‐demethylation and ethoxyresorufin‐O‐deethylation (r= 0.65 and r = 0.66, p < 0.001 ...
Y Dréano, Yvonne Dreano, François Berthou   +2 more
exaly   +3 more sources

Azelastine N-Demethylation by Cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in Human Liver Microsomes: Evaluation of Approach to Predict the Contribution of Multiple CYPs

Drug Metabolism and Disposition, 1999
Azelastine, an antiallergy and antiasthmatic drug, has been reported to be mainly N-demethylated to desmethylazelastine in humans. In the present study, Eadie-Hofstee plots of azelastine N-demethylation in human liver microsomes were biphasic. In microsomes from human B-lymphoblast cells, recombinant cytochrome P-450 (CYP)2D6 and CYP1A1 exhibited ...
M, Nakajima, S, Nakamura, S, Tokudome, N, Shimada, H, Yamazaki, T, Yokoi   +5 more
openaire   +2 more sources