Results 141 to 150 of about 10,662 (153)

Analysis of <i>CYP2D6</i> Gene Variant Frequencies in Iranian Population. [PDF]

Iran J Med Sci
Hokmabadi M, Asadifard E, Arbabi-Bidgoli S, Naghavi A, Hasanzad M.   +4 more
europepmc   +1 more source

Curated CYP450 Interaction Dataset: Covering the Majority of Phase I Drug Metabolism. [PDF]

Sci Data
Ni YH, Su YW, Yang SC, Hong JC, Du PA, Hsu YT, Kuo TC, Tseng YJ.   +7 more
europepmc   +1 more source

Building Sub-Saharan African PBPK Populations Reveals Critical Data Gaps: A Case Study on Aflatoxin B1. [PDF]

Toxins (Basel)
Lootens O, De Boevre M, De Saeger S, Van Bocxlaer J, Vermeulen A.   +4 more
europepmc   +1 more source

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Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions

Journal of Pharmacological and Toxicological Methods, 1994
Metabolic N-dealkylation is a commonly observed biotransformation with tertiary and secondary amine drugs and related N-alkylated amides, but surprisingly little is known about the cytochrome P-450 isozymes involved in these dealkylation reactions.
R T, Coutts, P, Su, G B, Baker
openaire   +2 more sources

Effect of Antipsychotic Drugs on Human Liver Cytochrome P-450 (CYP) Isoforms In Vitro: Preferential Inhibition of CYP2D6

Drug Metabolism and Disposition, 1999
The ability of antipsychotic drugs to inhibit the catalytic activity of five cytochrome P-450 (CYP) isoforms was compared using in vitro human liver microsomal preparations to evaluate the relative potential of these drugs to inhibit drug metabolism. The apparent kinetic parameters for enzyme inhibition were determined by nonlinear regression analysis ...
J G, Shin, N, Soukhova, D A, Flockhart
openaire   +2 more sources

Capillary electrophoretic investigation of the enantioselective metabolism of propafenone by human cytochrome P‐450 SUPERSOMES: Evidence for atypical kinetics by CYP2D6 and CYP3A4

ELECTROPHORESIS, 2006
AbstractAn enantioselective CE method was used to identify the ability of CYP450 enzymes and their stereoselectivity in catalyzing the transformation of propafenone (PPF) to 5‐hydroxy‐propafenone (5OH‐PPF) and N‐despropyl‐propafenone (NOR‐PPF). Using in vitro incubations with single CYP450 enzymes (SUPERSOMES), 5OH‐PPF is shown to be selectively ...
Minoo, Afshar, Wolfgang, Thormann
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Azelastine N-Demethylation by Cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in Human Liver Microsomes: Evaluation of Approach to Predict the Contribution of Multiple CYPs

Drug Metabolism and Disposition, 1999
Azelastine, an antiallergy and antiasthmatic drug, has been reported to be mainly N-demethylated to desmethylazelastine in humans. In the present study, Eadie-Hofstee plots of azelastine N-demethylation in human liver microsomes were biphasic. In microsomes from human B-lymphoblast cells, recombinant cytochrome P-450 (CYP)2D6 and CYP1A1 exhibited ...
M, Nakajima, S, Nakamura, S, Tokudome, N, Shimada, H, Yamazaki, T, Yokoi   +5 more
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Correlation between cytochrome P-450 CYP2D6 (CYP2D6) genotype and phenotype.

Zhongguo yao li xue bao = Acta pharmacologica Sinica, 2000
To study the correlation between CYP2D6 genotype and its phenotype.CYP2D6 genotyping was made by detecting CYP2D6*3, *4, *6, and *7 alleles with an allele-specific polymerase chain reaction procedure.The CYP2D6 genotypes were well correlated with its phenotypes in all 125 extensive metabolizers and in 43 poor metabolizers. Extensive metabolizers had at
S Q, Chen, P J, Wedlund
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Parkinson disease and cytochrome P-450 CYP2D6 genetic polymorphism

2000
We investigated the association of inactive CYP2D6 alleles *3, *4, *6, *7 and *8 with Parkinson disease (PD). Genotyping of the 41 patients and 145 healthy volunteers was performed by multiplex-allele specific PCR. Patient's phenotype was predicted from genotypes: extensive metabolizer (EM, two wild-type alleles), poor metabolizer (PM, two deficiency ...
Štefanović, Mario, Topić, Elizabeta, Ivanišević, Ana-Maria, Relja, Maja, Koršić, Marta   +4 more
openaire   +2 more sources