Results 141 to 150 of about 10,403 (155)
Nanopore sequencing-based genotyping suggested an association between CYP2D6 function and susceptibility to anxiety and depression. [PDF]
BMC Res NotesChua EW +7 more
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Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions
Journal of Pharmacological and Toxicological Methods, 1994 Metabolic N-dealkylation is a commonly observed biotransformation with tertiary and secondary amine drugs and related N-alkylated amides, but surprisingly little is known about the cytochrome P-450 isozymes involved in these dealkylation reactions.
Ronald T. Coutts, Glen B. Baker, Ping Su
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Drug Metabolism and Disposition, 1999 The ability of antipsychotic drugs to inhibit the catalytic activity of five cytochrome P-450 (CYP) isoforms was compared using in vitro human liver microsomal preparations to evaluate the relative potential of these drugs to inhibit drug metabolism. The apparent kinetic parameters for enzyme inhibition were determined by nonlinear regression analysis ...
J G, Shin, N, Soukhova, D A, Flockhart
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ELECTROPHORESIS, 2006 AbstractAn enantioselective CE method was used to identify the ability of CYP450 enzymes and their stereoselectivity in catalyzing the transformation of propafenone (PPF) to 5‐hydroxy‐propafenone (5OH‐PPF) andN‐despropyl‐propafenone (NOR‐PPF). Usingin vitroincubations with single CYP450 enzymes (SUPERSOMES), 5OH‐PPF is shown to be selectively produced ...
Wolfgang Thormann, Minoo Afshar
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Drug Metabolism and Disposition, 1999 Azelastine, an antiallergy and antiasthmatic drug, has been reported to be mainly N-demethylated to desmethylazelastine in humans. In the present study, Eadie-Hofstee plots of azelastine N-demethylation in human liver microsomes were biphasic. In microsomes from human B-lymphoblast cells, recombinant cytochrome P-450 (CYP)2D6 and CYP1A1 exhibited ...
M, Nakajima +5 more
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Cancer research, 1995 We describe a case-control study to identify associations between polymorphism at the cytochrome P-450 (CYP2D6) and glutathione S-transferase (GSTT1 and GSTM1) loci and susceptibility to astrocytoma and meningioma. Accordingly, genotype frequencies in 112 astrocytoma and 50 meningioma patients were compared with frequencies in 577 controls.
J, Elexpuru-Camiruaga +9 more
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[Anti-cytochrome P 450 2D6 antibody(CYP2D6 antibody)].
Nihon rinsho. Japanese journal of clinical medicine, 2010 Nobuyuki, Amino, Mako, Fujiwara
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[Immunological tests: Anti-cytochrome P 450 2D6 antibody (CYP2D6 antibody)].
Nihon rinsho. Japanese journal of clinical medicine, 2005 Nobuyuki, Amino, Sumihisa, Kubota
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Correlation between cytochrome P-450 CYP2D6 (CYP2D6) genotype and phenotype.
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 2000To study the correlation between CYP2D6 genotype and its phenotype.CYP2D6 genotyping was made by detecting CYP2D6*3, *4, *6, and *7 alleles with an allele-specific polymerase chain reaction procedure.The CYP2D6 genotypes were well correlated with its phenotypes in all 125 extensive metabolizers and in 43 poor metabolizers. Extensive metabolizers had at
S Q, Chen, P J, Wedlund
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Parkinson disease and cytochrome P-450 CYP2D6 genetic polymorphism
2000We investigated the association of inactive CYP2D6 alleles *3, *4, *6, *7 and *8 with Parkinson disease (PD). Genotyping of the 41 patients and 145 healthy volunteers was performed by multiplex-allele specific PCR. Patient's phenotype was predicted from genotypes: extensive metabolizer (EM, two wild-type alleles), poor metabolizer (PM, two deficiency ...
Štefanović, Mario +4 more
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