Results 1 to 10 of about 5,159 (106)
The Effect of Efavirenz and Rufinamide on the Pharmacokinetics and Safety of Quizartinib: Two Phase 1 Studies in Healthy Participants. [PDF]
Clin Transl SciABSTRACT Quizartinib is an oral, potent, selective FMS‐like tyrosine kinase 3 (FLT3) inhibitor, approved for the treatment of FLT3‐internal tandem duplication (ITD)–positive acute myeloid leukemia (AML) and under investigation in patients with newly diagnosed FLT3‐ITD–negative AML.
Yoo Y +8 more
europepmc +2 more sources
The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Cytochrome P450 3A4 (CYP3A4) is one of the most important members of the cytochrome P450 subfamily, which is involved in the catalytic process of many drug activation or deactivation. Meanwhile, it is also a risk factor for drug‐induced toxic reactions.
Wang F +7 more
europepmc +2 more sources
Interplay of Vitamin D and Polymorphisms in Endocrine Disorders and Cancer [PDF]
Endocrinology and Metabolism, 2022 Vitamin D has received considerable optimistic attention as a potentially important factor in many pathological states over the past few decades. However, the proportion of the active form of vitamin D metabolites responsible for biological activity is ...
Siva Swapna Kasarla +3 more
doaj +1 more source
Diagnostics, 2022 Midazolam is a drug that is metabolized by cytochrome P450 (CYP450) enzymes, particularly CYP3A4 and CYP3A5. The present study aimed to determine the sex and age influence on association of CYP450 polymorphism with midazolam levels in critically ill ...
Carmen Flores-Pérez +6 more
doaj +1 more source
Antiviral Therapy, 2022 Ergotism is a rare cause of peripheral vasoconstriction with varying presentation depending on the affected vessels. Coronary vasospasm is a rare, potentially fatal manifestation of ergotism.
Cheng-En Wu +3 more
doaj +1 more source
Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1
Microbiome, 2023 Background Following solid organ transplantation, tacrolimus (TAC) is an essential drug in the immunosuppressive strategy. Its use constitutes a challenge due to its narrow therapeutic index and its high inter- and intra-pharmacokinetic (PK) variability.
Alexandra L. Degraeve +7 more
doaj +1 more source
Pharmacology Research & Perspectives, 2020 Synthetic cannabinoids (SCBs), designer drugs marketed as legal alternatives to marijuana, act as ligands to cannabinoid receptors; however, they have increased binding affinity and potency, resulting in toxicity symptoms such as cardiovascular incidents,
Sabrina Jones +6 more
doaj +1 more source
Auto-Induction Effect of Chloroxoquinoline on the Cytochrome P450 Enzymes of Rats Associated with CYP 3A and 1A. [PDF]
PLoS ONE, 2015 To investigate the auto-induction of cytochrome P450 (CYP450) by Chloroxoquinoline (CXL), a novel anticancer drug. Three experiments related to the induction of CYP450 were performed: a) In vitro use of the rat fresh hepatocytes model; b) In vivo ...
Xin Li +7 more
doaj +1 more source
Inhibitory Effect of Antituberculosis Drugs on Human Cytochrome P450-Mediated Activities
Journal of Pharmacological Sciences, 2004 The potential for drug-drug interactions mediated by the inhibition of cytochrome P-450 (CYP) were concerned during antituberculosis therapy. However, the information regarding human CYP inhibition by antituberculosis drugs is limited to isoniazid.
Yuki Nishimura +3 more
doaj +1 more source
Monitoring imatinib plasma concentrations in chronic myeloid leukemia
Revista Brasileira de Hematologia e Hemoterapia, 2011 Imatinib has proved to be effective in the treatment of chronic myeloid leukemia, but plasma levels above 1,000 ng/mL must be achieved to optimize activity.
Darlize Hübner Martins +6 more
doaj +1 more source