Results 1 to 10 of about 5,186 (110)
Interplay of Vitamin D and Polymorphisms in Endocrine Disorders and Cancer [PDF]
Endocrinology and Metabolism, 2022 Vitamin D has received considerable optimistic attention as a potentially important factor in many pathological states over the past few decades. However, the proportion of the active form of vitamin D metabolites responsible for biological activity is ...
Siva Swapna Kasarla +3 more
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Diagnostics, 2022 Midazolam is a drug that is metabolized by cytochrome P450 (CYP450) enzymes, particularly CYP3A4 and CYP3A5. The present study aimed to determine the sex and age influence on association of CYP450 polymorphism with midazolam levels in critically ill ...
Carmen Flores-Pérez +6 more
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Antiviral Therapy, 2022 Ergotism is a rare cause of peripheral vasoconstriction with varying presentation depending on the affected vessels. Coronary vasospasm is a rare, potentially fatal manifestation of ergotism.
Cheng-En Wu +3 more
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Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1
Microbiome, 2023 Background Following solid organ transplantation, tacrolimus (TAC) is an essential drug in the immunosuppressive strategy. Its use constitutes a challenge due to its narrow therapeutic index and its high inter- and intra-pharmacokinetic (PK) variability.
Alexandra L. Degraeve +7 more
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Pharmacology Research & Perspectives, 2020 Synthetic cannabinoids (SCBs), designer drugs marketed as legal alternatives to marijuana, act as ligands to cannabinoid receptors; however, they have increased binding affinity and potency, resulting in toxicity symptoms such as cardiovascular incidents,
Sabrina Jones +6 more
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Auto-Induction Effect of Chloroxoquinoline on the Cytochrome P450 Enzymes of Rats Associated with CYP 3A and 1A. [PDF]
PLoS ONE, 2015 To investigate the auto-induction of cytochrome P450 (CYP450) by Chloroxoquinoline (CXL), a novel anticancer drug. Three experiments related to the induction of CYP450 were performed: a) In vitro use of the rat fresh hepatocytes model; b) In vivo ...
Xin Li +7 more
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Inhibitory Effect of Antituberculosis Drugs on Human Cytochrome P450-Mediated Activities
Journal of Pharmacological Sciences, 2004 The potential for drug-drug interactions mediated by the inhibition of cytochrome P-450 (CYP) were concerned during antituberculosis therapy. However, the information regarding human CYP inhibition by antituberculosis drugs is limited to isoniazid.
Yuki Nishimura +3 more
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Monitoring imatinib plasma concentrations in chronic myeloid leukemia
Revista Brasileira de Hematologia e Hemoterapia, 2011 Imatinib has proved to be effective in the treatment of chronic myeloid leukemia, but plasma levels above 1,000 ng/mL must be achieved to optimize activity.
Darlize Hübner Martins +6 more
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Predictors of Irinotecan Toxicity and Efficacy in Treatment of Metastatic Colorectal Cancer
Acta Medica, 2012 The colorectal cancer ranks high among the malignant tumours in incidence and mortality and irinotecan is standardly used in palliative treatment of metastatic disease in every therapeutic line.
Adam Paulík +2 more
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Revista do Colégio Brasileiro de CirurgiõesRESUMO Os polimorfismos genéticos do CYP3A5 têm sido apontados enquanto fatores influenciadores na eficácia farmacológica com tacrolimo em pacientes em terapia imunossupressora no pós-transplante hepático.
Lucas Soares Bezerra +6 more
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