Results 91 to 100 of about 5,186 (110)

[Clinical significance of some genetic polymorphisms of cytochrome P-450 subfamilies CYP2D, CYP2E and CYP3A--part II].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2010
Polymorphism of drugs biotransformation is clinically significant from the point of view of the effectiveness and safety of pharmacotherapy and an increased risk of some illnesses. The paper presents molecular mechanisms and clinical implication of several genetic polymorphisms of cytochrome P-450 (CYP) xenobiotics metabolizing enzymes and genetic ...
Anna, Wojtczak, Jadwiga, Skretkowicz
openaire   +1 more source

Role of cytochrome P-450 from the human CYP3A gene family in the potentiation of morpholino doxorubicin by human liver microsomes.

Cancer research, 1992
The cytotoxicity of the morpholino derivative of doxorubicin (MRA) can be potentiated 50- to 100-fold by human liver microsomes and NADPH (J. Natl. Cancer Inst., 81: 1034, 1989). This metabolic potentiation is inhibited by carbon monoxide or hypoxia, indicating that it is cytochrome P-450-dependent.
A D, Lewis, D H, Lau, G E, Durán, C R, Wolf, B I, Sikic   +4 more
openaire   +1 more source

Identification of polymorphisms in the 3′-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism

Xenobiotica, 2010
David J Greenblatt, L L Von Moltke
exaly  

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily

Biochemical Pharmacology, 1994
S A Wrighton, Mark Vandenbranden, S D Hall   +2 more
exaly  

In vivo induction of cytochrome P450 CYP3A expression in rat leukocytes using various inducers

Biochemical Pharmacology, 1996
Peter H Roos, G G Chabot
exaly  

Effect of classic and atypical neuroleptics on cytochrome P450 3A (CYP3A) in rat liver

Pharmacological Reports, 2012
Władyslawa Anna Daniel, Anna Haduch, Jacek Wójcikowski   +2 more
exaly  

Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes

Toxicology Letters, 1998
David E Amacher, D E Amacher
exaly  

Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver

Toxicology, 1998
Brian Lake, Morag E Cunninghame, Roger J Price   +2 more
exaly  

Clinical Drug–Drug Interactions Through Cytochrome P450 3A (CYP3A) for the Selective ALK Inhibitor Alectinib

Clinical Pharmacology in Drug Development, 2017
Peter Morcos
exaly  

Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr(−/−) mouse liver microsomes

Biochemical Pharmacology, 1999
Michael Perloff, David J Greenblatt, Lisa L Von Moltke   +2 more
exaly