Results 81 to 90 of about 5,159 (106)

Canine duodenal organoids as a functional platform for intestinal CYP regulation and drug metabolism studies. [PDF]

Drug Metab Dispos
Nakazawa M, Court MH, Ambrosini YM.
europepmc   +1 more source

Dual effects of indoxyl sulfate on modulation of human hepatic CYP3A activity, with individual differences. [PDF]

PLoS One
Togao M, Asakawa N, Wagai G, Ohta-Takada Y, Otsuka J, Ando M, Kurita A, Kawakami K.   +7 more
europepmc   +1 more source

Pharmacokinetics of midazolam and hepatic cytochrome P450 3A activity in an in vivo extracorporeal membrane oxygenation rat model. [PDF]

Sci Rep
Sato Y, Motoishi E, Kakuba R, Nagatsuka Y, Abe T, Fujii Y.   +5 more
europepmc   +1 more source

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Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1)

Biochimica Et Biophysica Acta - General Subjects, 1994
A cDNA encoding a novel member of the cytochrome P-450 superfamily, Cyp3a-13, has been isolated from mouse liver cDNA library by hybridization screening. The Cyp3a-13 encoded 503 amino acid residues and shared 71% amino acid identity with Cyp3a-11.
Susumu Itoh, M Sawada, Hisashi Hashimoto   +2 more
exaly   +3 more sources

Particular ability of cytochrome P-450 CYP3A to reduce glyceryl trinitrate in rat liver microsomes: Subsequent formation of nitric oxide

Chemico-Biological Interactions, 1993
Glyceryl trinitrate was denitrated in rat hepatic subcellular fractions, with formation of glyceryl dinitrates and glyceryl mononitrates. Among differently treated-rat liver microsomes, the highest microsomal activity was obtained under anaerobic conditions with microsomal preparations from dexamethasone-treated rats and NADPH.
Marcel Delaforge, Denis Servent
exaly   +4 more sources

Inhibition of Cytochrome P-450 3A (CYP3A) in Human Intestinal and Liver Microsomes: Comparison of Ki Values and Impact of CYP3A5 Expression

Drug Metabolism and Disposition, 1999
The purpose of this study was to compare the kinetics of intestinal and hepatic cytochrome P-450 3A (CYP3A) inhibition by using microsomal midazolam 1'-hydroxylation as a marker of enzyme activity. The effect of two antifungal agents commonly implicated in CYP3A drug-drug interactions was examined.
Kenneth E Thummel, Danny D Shen, Kent L Kunze   +2 more
exaly   +3 more sources

Insulin Differentially Affects Xenobiotic-Enhanced, Cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A Expression in Primary Cultured Rat Hepatocytes

Journal of Pharmacology and Experimental Therapeutics, 1999
Uncontrolled diabetes results in enhanced expression of cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A. Because of the simultaneous and confounding metabolic and hormonal changes that occur in vivo as a consequence of diabetes, primary cultured rat hepatocytes provide an excellent model system for examination of the effects of insulin on P-450 ...
Kimberley J Woodcroft, Raymond F Novak
exaly   +3 more sources

The Glucocorticoid Receptor Is Essential for Induction of Cytochrome P-4502B by Steroids but Not for Drug or Steroid Induction of CYP3A or P-450 Reductase in Mouse Liver

Drug Metabolism and Disposition, 2000
Cytochrome P-4503A, CYP2B, and P-450 reductase are induced by glucocorticoids, antiglucocorticoids such as pregnenolone 16alpha-carbonitrile, and drugs such as rifampin and phenobarbital. Although the pregnane X receptor is reported to mediate steroid and drug activation of CYP3A via a conserved cis-element in CYP3A genes, discrepancies exist between ...
Erin G Schuetz, GÜNTHER Schutz, Kazuto Yasuda   +2 more
exaly   +3 more sources

N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors.

The Journal of Pharmacology and Experimental Therapeutics, 1995
Biotransformation of amitriptyline (AMI) to its demethylated product nortriptyline (NT) was studied in vitro with human liver microsomes from four different donors, preselected to reflect a range of metabolic rates. Reaction velocity versus substrate concentration was consistent with a sigmoid Vmax model.
J, Schmider, D J, Greenblatt, L L, von Moltke, J S, Harmatz, R I, Shader   +4 more
openaire   +2 more sources

[Clinical significance of some genetic polymorphisms of cytochrome P-450 subfamilies CYP2D, CYP2E and CYP3A--part II].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2010
Polymorphism of drugs biotransformation is clinically significant from the point of view of the effectiveness and safety of pharmacotherapy and an increased risk of some illnesses. The paper presents molecular mechanisms and clinical implication of several genetic polymorphisms of cytochrome P-450 (CYP) xenobiotics metabolizing enzymes and genetic ...
Anna, Wojtczak, Jadwiga, Skretkowicz
openaire   +1 more source