Results 31 to 40 of about 9,195 (133)

Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults [PDF]

, 2017
Background The clearance of cytochrome P450 (CYP) 3A substrates is reported to be reduced with lower age, inflammation and obesity. As it is unknown what the overall influence is of these factors in the case of obese adolescents vs.
Anker, J.N. (John) van den, Barrett, J.S. (Jeffrey), Brill, M.J.E. (Margreke J.E.), Dongen, E.H.P.A. (Eric) van, Knibbe, C.A.J. (Catherijne), Ramshorst, B. (Bert) van, van Rongen, A. (Anne), Vaughns, J.D. (Janelle D.), Välitalo, P.A.J. (Pyry A. J.)   +8 more
core   +4 more sources

Vitamin C Alleviates Oxidative Stress in Silver Carp (Hypophthalmichthys molitrix) Fingerlings Exposed to Toxicity Induced by Temephos and Buprofezin

Aquaculture Research, Volume 2026, Issue 1, 2026.
Context Organophosphates and chitin synthesis inhibitor pesticides pose a significant indirect threat to fish populations, necessitating effective remedial measures. Objective Supplementation with vitamin C (Vit C) in fish feed as a counteracting strategy to mitigate pesticides effect was explored in silver carp (Hypophthalmichthys molitrix ...
Sumaira Hassan, Irfan Zia Qureshi, Modhi O. Alotaibi, Mitesh Patel, Mohd Adnan, Nawaf Alshammari, Shakira Ghazanfar   +6 more
wiley   +1 more source

Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class [PDF]

, 2016
New psychoactive substances (NPS) are not tested for their cytochrome P450 (CYP) inhibition potential before consumption. Therefore, this potential was explored for tryptamine-derived NPS (TDNPS) including alpha-methyl tryptamines (AMTs), dimethyl ...
Brandt, SD, Dinger, J, Maurer, HH, Meyer, MR, Woods, C   +4 more
core   +1 more source

In Vitro Assessment of Drug‐Induced Liver Injury Using Three‐Dimensional Cultured HepaSH Cells Derived From Chimeric Mouse Model With Humanized Liver

Journal of Applied Toxicology, Volume 45, Issue 12, Page 2641-2653, December 2025.
ABSTRACT Drug‐induced liver injury (DILI) is a serious adverse event and a common cause of postmarketing drug withdrawal. Despite nonclinical assessments of DILI risk, which are predominantly conducted in experimental animals, DILI remains a frequent adverse event, highlighting the need to improve nonclinical assessments.
Xingming Liu, Yuichiro Higuchi, Yuta Sakamoto, Shota Yanagida, Shotaro Uehara, Hiroshi Suemizu, Yasunari Kanda, Hiroyuki Kawagishi   +7 more
wiley   +1 more source

Pharmacokinetic and Pharmacogenetic aspects of drug-drug interactions between antiretroviral and anti-tuberculosis drugs in Ethiopian patients: Implication for optimization of TB-HIV co-treatment [PDF]

, 2013
TB and HIV are immuno-pathologically interacting epidemic infectious diseases affecting the lives of millions globally & sub-Saharan African region accounts the highest burden of both diseases.
Habtewolde Eyakem, Abiy
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen [PDF]

, 2011
Oxygen promotes closure of the ductus arteriosus at birth. We have previously presented a scheme for oxygen action with a cytochrome P450 (CYP450) hemoprotein and endothelin-1 (ET-1) being, respectively, sensor and effector, and a hypothetical ...
B. Baragatti, F. Coceani
core   +1 more source

Tuberculous Retroperitoneal Lymphadenitis After Kidney Transplantation That Was Difficult to Diagnose and Treat: A Case Report

IJU Case Reports, Volume 8, Issue 6, Page 558-562, November 2025.
ABSTRACT Introduction We present a rare case of tuberculous retroperitoneal lymphadenitis after kidney transplantation that was difficult to diagnose and treat. Case Presentation A 52‐year‐old man who received a kidney transplantation from his wife presented with right lower quadrant pain.
Ryota Nakayasu, Yuki Kita, Yuki Teramoto, Kenji Nakamura, Toru Sakatani, Kimihiko Masui, Takayuki Goto, Ryoichi Saito, Takashi Kobayashi   +8 more
wiley   +1 more source

CYP3A5 variant allele frequencies in Dutch Caucasians [PDF]

, 2002
BACKGROUND: Enzymes of the cytochrome P450 3A (CYP3A) family are responsible for the metabolism of >50% of currently prescribed drugs. CYP3A5 is expressed in a limited number of individuals.
Anker, J.N. (John) van den, Heiden, I.P. (Ilse) van der, Lindemans, J. (Jan), Schaik, R.H.N. (Ron) van   +3 more
core  

Derivation of a health‐based guidance value for Δ8‐tetrahydrocannabinol (Δ8‐THC) and its occurrence in food

EFSA Journal, Volume 23, Issue 11, November 2025.
Abstract The European Food Safety Authority (EFSA) was asked to deliver a scientific opinion on the derivation of a health‐based guidance value (HBGV) for Δ8‐tetrahydrocannabinol (Δ8‐THC) in food with an assessment of the occurrence of Δ8‐THC and the co‐occurrence with Δ9‐THC in hemp and hemp‐derived products.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Birgit Dusemund, Carlo Nebbia, Stefan Weigel, Claudia Cascio, Anna Christodoulidou, José Cortiñas Abrahantes, Bruno Dujardin, Andrea Gissi, Lydia Alarcón Asensio, Eleni Gkimprixi, Tuuli Tauriainen, Laurent Bodin   +30 more
wiley   +1 more source