Results 151 to 160 of about 42,048 (270)

The novel third-generation antipsychotic drug brexpiprazole affects hepatic transcription factors, serum hormone levels, and cytochrome P450 enzymes after prolonged treatment: pharmacological significance. [PDF]

Pharmacol Rep
Danek PJ, Pukło R, Daniel WA.
europepmc   +1 more source

N‐Acetylcysteine Attenuates Mancozeb‐Induced Hepatorenal Injury by Modulating Oxidative Stress, Inflammatory Signaling, and Apoptotic Pathways in Rats

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
N‐acetylcysteine (NAC) attenuated mancozeb‐induced hepatotoxicity and nephrotoxicity in rats by reducing oxidative stress, inflammation, and apoptosis. NAC restored antioxidant balance and suppressed inflammatory and apoptotic signaling pathways, suggesting a protective role against mancozeb‐related hepatorenal injury. ABSTRACT Mancozeb (MNZ), a widely
Ali Çakırlı, Metin Deniz Karakoç, Özlem Özmen, Münevver Nazlıcan Kaplan, Osman Çiftçi   +4 more
wiley   +1 more source

Enzyme-substrate-inactivator complex formation can impact time-dependent inhibition kinetics. [PDF]

Drug Metab Dispos
Yadav J, Wahlstrom J, Korzekwa K, Nagar S.   +3 more
europepmc   +1 more source

DAMP Laden Extracellular Vesicles From the Airways of Patients With Severe SARS‐CoV‐2 Respiratory Infection Compromise Inflammation and Cellular Metabolism

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Extracellular vesicles from severe COVID‐19 airways carry depleted miRNAs and elevated DAMPs, reprogramming monocytes toward senescence, impaired metabolism, and predominantly reduced cytokine responses. However, they drive excess IL‐8 production, amplifying neutrophil recruitment and dysfunctional inflammation across the respiratory tract.
April Rees, Oliver Richards, Molly E Raikes, Megan Chambers, Sophie G Reed, Ceri Battle, Hannah Toghill, Luke Newey, Tyler J Joseph, Haiyan An, Hui Zhang, Iain Perry, Jason Webber, Nicholas Jones, Catherine A Thornton   +14 more
wiley   +1 more source

Associations of CYP2B6, CYP2C19, and CYP2D6 isoforms and phenoconversion with sertraline pharmacokinetics. [PDF]

PLoS One
Tapia-Alzuguren B, Canga-Espina C, Molero P, Aldaz A.   +3 more
europepmc   +1 more source

Evaluation of Salt‐Tolerant Guar (Cyamopsis tetragonoloba L.) Genotypes Based on Physiological, Biochemical, and Yield‐Related Traits

Legume Science, Volume 8, Issue 2, June 2026.
ABSTRACT The 15 guar genotypes were exposed to different concentrations of salt (0, 10, and 15 dS m−1 NaCl) in a factorial experiment (RCBD, r = 3) and different morpho‐physiological, physiological, growth, and yield characteristics were assessed. The lowest seed gum (21.11%), carbohydrate (23.59%), protein content (24.20%), fat (2.21%), fiber (9.38%),
WarqaaMuhammed ShariffAl‐Sheikh, Sahar A. A. Malik Al‐Saadi, Karzan Omer Qader, Heidar Meftahizade   +3 more
wiley   +1 more source

Comparison of cytochrome P450 activity and mRNA expression in canine vs. human hepatocytes after acetaminophen, diclofenac, or valproic acid exposure. [PDF]

J Vet Sci
Kang JR, Lee J, Suh HN.
europepmc   +1 more source

Genomic and Transcriptomic Insights Into Salinity Tolerance in Dry Pea

Legume Science, Volume 8, Issue 2, June 2026.
ABSTRACT Salinity is a major crop production constraint in dry pea (Pisum sativum L.), making the development of salt‐tolerant varieties essential to improve crop productivity and land‐use efficiency. The genetic mechanisms of salt tolerance in dry pea are largely unknown, and research on salt‐tolerant genes is limited.
Shailesh Raj Acharya, Emmanuella Bredu, Harry Navasca, Hannah Worral, Lisa Piche, Rica Amor Saludares, Josephine Princy Johnson, Clarice Coyne, Kevin McPhee, Qi Zhang, Michael Ostlie, Nonoy Bandillo   +11 more
wiley   +1 more source

Characterization of the Orphan Cytochrome P450 CYP107J1 From Bacillus subtilis Through Peroxygenase Activity Engineering. [PDF]

Microb Biotechnol
Kato H, Hashimoto T, Das T, Doherty DZ, Bell SG, Furuya T.   +5 more
europepmc   +1 more source

Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application

MedComm, Volume 7, Issue 6, June 2026.
The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang, Runkang Zhao, Fan Zhang, Dandan Guo, Qing Li, Zhijun Shen, Ruiqing Gao, Chenyu Gao, Zhao Xie, Sentao Fu, Peng Luo, Bufu Tang, Ling Wang   +12 more
wiley   +1 more source