Results 161 to 170 of about 39,545,119 (227)

Evaluation of the cytochrome P450-mediated drug interaction profile of olorofim. [PDF]

Antimicrob Agents Chemother
Cornelissen K, Rex JH, Zinzi D, Law D, Upcott Gill R, Jones HM, Maertens J, Chen SC-A, Brüggemann R.   +8 more
europepmc   +1 more source

Acrylamide‐Induced Developmental and Molecular Toxicity in Drosophila melanogaster: The Role of Vanillic Acid in CncC/Keap1 Modulation

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Vanillic acid, a dietary phenolic, dose‐dependently protects Drosophila melanogaster from acrylamide‐induced oxidative damage, DNA strand breaks, and developmental toxicity by modulating CncC/Keap1 redox signaling—establishing vanillic acid as a candidate natural protective agent against a major environmental contaminant.
Fahriye Zemheri‐Navruz, Sinan Ince, Gamze Ataman   +2 more
wiley   +1 more source

High-level expression of full-length human CYP2E1 in Escherichia coli: Comparison of full-length human CYP2E1 to truncated counterpart shows enhanced association with redox partners. [PDF]

Drug Metab Dispos
Sun Y, Amunugama P, Osawa Y, Zhang H.
europepmc   +1 more source

Chronic Contractile Activity Remediates Lysosomal Dysfunction in a Muscle Cell Lysosomal Disease Model

Journal of Cellular Physiology, Volume 241, Issue 9, September 2026.
Bafilomycin A1‐induced lysosomal dysfunction can be mitigated by CCA in muscle myotubes. The curcumin analogue C1 similarly decreases lysosomal accumulation, modestly improves function and increases mitochondrial content, suggesting that both CCA and C1 may represent potential strategies for alleviating lysosomal dysfunction and supporting muscle cell ...
Debasmita Bhattacharya, Neushaw Moradi, David A. Hood   +2 more
wiley   +1 more source

BV100 (rifabutin IV) drug interaction studies in healthy subjects with index CYP450 3A probes midazolam and itraconazole. [PDF]

J Antimicrob Chemother
Delique P, Kemmer C, Husband L, Lakner G, Jäger J, Jung F, Shorr AF, Dale GE.   +7 more
europepmc   +1 more source

Hybrid Quatsome‐Encapsulated Silver Nanoparticles as Stable Plasmonic Substrates for Surface‐Enhanced Raman Scattering

Journal of Raman Spectroscopy, Volume 57, Issue 9, Page 1603-1616, September 2026.
In this work, silver nanoparticles encapsulated within quatsome membranes have shown to preserve their plasmonic properties for at least 165 days without aggregation. These hybrid nanostructures enable strong SERS enhancement of pyrene and Prodan by confining the molecules within a few nanometers from the silver surface.
Renato Cezar Peramezza Ribeiro, Caio Hiroaki Miyake, Pedro Henrique Figueiredo Backes Costa, Jhenifer Hallen Braga Mauricio, Ana Luiza Correa Januário, Diogo Soga, Evandro Luiz Duarte, Márcia de Almeida Rizzutto, Rômulo Augusto Ando, Antonio Rodrigues da Cunha, Erix Alexander Milán‐Garcés   +10 more
wiley   +1 more source

The role of Zearalenone in epigenetic modifications of candidate genes in Nellore heifers. [PDF]

Trop Anim Health Prod
Coelho LADS, Barbero RP, Pereira PRMT, Polido CEB, de Aguiar ACSR, Santos HA, de Mello MRB, Kern EL, Andia DC, Barbero MMD.   +9 more
europepmc   +1 more source

Prevention of Myc‐Driven Prostate Cancer in Mice by Oral Administration of Sulforaphane

Molecular Carcinogenesis, Volume 65, Issue 9, Page 1052-1062, September 2026.
ABSTRACT Prevention is desirable to reduce suffering and death from prostate cancer. However, a clinical‐grade intervention for the prevention of this malignancy is still lacking. This study was undertaken to determine the feasibility of prostate cancer prevention by broccoli constituent sulforaphane (SFN) because epidemiological studies have suggested
Krishna B. Singh, Eun‐Ryeong Hahm, Bruce L. Jacobs, Shivendra V. Singh   +3 more
wiley   +1 more source

Effect of Individual and Combined Cytochrome P450 Activity Scores on Symptom Improvement and Side Effects in Youth Treated With Sertraline. [PDF]

Clin Transl Sci
Gerlach S, Maruf AA, Shaheen SM, McCloud R, Heintz M, McAusland L, Arnold PD, Bousman CA.   +7 more
europepmc   +1 more source

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source