Results 181 to 190 of about 42,048 (270)

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans. [PDF]

Clin Pharmacol Ther
Aurinsalo L, Lapatto-Reiniluoto O, Kurkela M, Neuvonen M, Moilanen E, Niemi M, Tornio A, Backman JT.   +7 more
europepmc   +1 more source

Targeting DNMT1 Attenuates Radiation‐Induced Heart Disease: An Integrated Multiomic and Functional Study

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Our study elucidates that DNMT1 promotes radiation‐induced heart disease by orchestrating aberrant epigenetic regulation and impairing cardioprotective signaling. Inhibition of DNMT1 mitigates this damage, revealing a translatable strategy to prevent RIHD.
Gang Wang, Yan‐ling Li, Bo‐wen Wang, Rong Wang, Yan Wang, Yan‐biao Shu, Wen‐bo Zhang, Pan Wu, Yu‐jie Hu, Wei‐jie Lu, Ping Xie   +10 more
wiley   +1 more source

In Silico Comparison of Rifampicin and 25-desacetyl Rifampicin-Induced PXR-Mediated CYP450 Transcriptional Response in 3D Primary Human Hepatocytes. [PDF]

Bull Math Biol
Kahiya ET, Smutný T, Smutná L, Duintjer Tebbens J, Pávek P, Bernhauerová V.   +5 more
europepmc   +1 more source

SCD1 Regulates Osteoclast Differentiation by Modulating Arachidonic Acid Metabolism and Mitochondrial Homeostasis

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
This graphical abstract illustrates that SCD1 inhibition by A939572 or the targeted nanovesicle POCM‐NP@A939572 reprograms arachidonic acid metabolism via the COX1‐HPGDS‐PGD2 axis and impairs mitochondrial homeostasis, thereby suppressing osteoclastogenesis and alleviating bone loss in osteoporosis.
Yihao Zhao, Xiaoan Wei, Haihao Wu, Chengjun Yao, Zeyu Zheng, Weishao Chen, Zhenhua Feng, Bao Huang, Zimin Cai, Qize Xue, Jian Chen, Fengdong Zhao, Junhui Liu   +12 more
wiley   +1 more source

Engineering a cytochrome P450 enzyme as a peroxygenase for selective hydroxylation of steroids. [PDF]

Nat Commun
Tang T, Wang R, Chen Y.
europepmc   +1 more source

Recombinant mouse cytochromes P1-450 and P3-450: enzymatic characterization of the hemoprotein expressed in human cells infected with recombinant vaccinia virus.

We expressed mouse cytochrome P1-450 and P3-450 using recombinant vaccinia virus gene expression system in HeLa cells that were devoid of significant basal levels of P-450.
Tsuji, Takao, Thorgeirsson, Snorri S, Nouso, Kazuhiro, Battula, Narayama, Higashi, Toshihiro   +4 more
core  

Elucidating the binding and metabolic interactions of sunitinib and sorafenib with Cytochrome P450s CYP2U1 and CYP2D6. [PDF]

Mol Pharmacol
Tang TY, Li Y, Chapman P, Tajkhorshid E, Das A.   +4 more
europepmc   +1 more source

CYP2E1 and CYP2D6 in Anti-Tuberculosis Drug-Induced Liver Injury: Mechanisms, Epigenetic Regulation, and Translational Implications. [PDF]

Clin Transl Sci
Prakongsup P, Udomsinprasert W.
europepmc   +1 more source

Brewing an Interaction: Non-commercial Green Tea-Associated Supratherapeutic Tacrolimus Levels Presenting With Gastrointestinal Symptoms. [PDF]

Cureus
Modi R, Patel F, Chag A, Joshi MR.
europepmc   +1 more source

Integrating Genetic Variants and Expression Profiles of Pharmacogenes to Investigate Resistance to Antidepressant Treatment. [PDF]

Medicina (Kaunas)
Pisanu C, Squassina A, Perera-Bel J, Silva RC, Buson L, Sires AM, Bortolomasi M, Menesello V, Perusi G, Carpiniello B, Ferensztajn-Rochowiak E, Rybakowski F, Sanz F, Manchia M, Potier MC, Dierssen M, Prompt Study Group, Baune BT, Gennarelli M, Minelli A.   +19 more
europepmc   +1 more source