Results 181 to 190 of about 39,545,119 (227)

Revisiting the PCR‐Based Molecular Approaches for Mycotoxigenic Fusarium Species Detection and Quantification in Wheat

open access: yesComprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.
ABSTRACT Fusarium species cause yield losses in wheat production through fusarium head blight (FHB) and the associated contamination of regulated mycotoxins, such as trichothecenes and zearalenone. Despite the widespread use of PCR‐based molecular approaches for Fusarium detection, quantification, and chemotyping, most primers were developed prior to ...
Kavitha Vijeandran   +9 more
wiley   +1 more source

Ketogenic Diet and β‐Hydroxybutyrate Suppress Bladder Cancer Growth and Enhance Anti‐PD‐L1 Immunotherapy Efficacy

open access: yesCancer Science, Volume 117, Issue 9, Page 2379-2396, September 2026.
Ketogenic diet and β‐hydroxybutyrate (β‐HB) suppress bladder cancer growth through direct anti‐tumor mechanisms and enhance anti‐PD‐L1 immunotherapy efficacy. β‐HB upregulates PD‐L1 via JAK2‐STAT3 activation and remodels the tumor immune microenvironment, sensitizing tumors to immune checkpoint blockade. ABSTRACT The limited clinical efficacy of immune
Yuan Zeng   +6 more
wiley   +1 more source

P450 Fusion Protein Expressed in <i>E. coli</i> for Regioselective Hydroxylation of Flavonoids. [PDF]

open access: yesMolecules
Dulak K   +6 more
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling to Predict Human Starting Dose and Pharmacokinetics for Rocbrutinib

open access: yesClinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Rocbrutinib is a fourth‐generation Bruton's tyrosine kinase (BTK) inhibitor that covalently binds wild‐type BTK and non‐covalently engages the C481S mutant. Its pharmacokinetic (PK) characteristics in healthy Chinese subjects remain unclear. This study aimed to support maximum recommended starting dose (MRSD) selection and predict exposure of ...
Lu Wang   +6 more
wiley   +1 more source

Downregulating CHI3L2 via the STAT3 Pathway: The Mechanism of Calcitriol in Suppressing Psoriatic Inflammation and Keratinocyte Hyperproliferation

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT Psoriasis is a chronic inflammatory skin disorder driven by immune dysregulation and keratinocyte hyperproliferation. Calcitriol, the active form of vitamin D, shows therapeutic potential, but its molecular mechanisms remain incompletely understood. CHI3L2 (chitinase‐3‐like protein 2) is a member of the chitinase‐like protein family implicated
Qingqing He, Junlin Liu
wiley   +1 more source

Ketogenic diet-induced changes in hepatic drug metabolism with potential implications for ozanimod pharmacokinetics in mice. [PDF]

open access: yesPLoS One
Frybortova V   +8 more
europepmc   +1 more source

Gene‐Based Clustering Identifies QSOX1 and IL1RAP as Biomarkers of Metabolic Dysfunction‐Associated Steatotic Liver Disease

open access: yesLiver International, Volume 46, Issue 9, September 2026.
ABSTRACT Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a progressive liver disease that ranges from simple steatosis to inflammation, fibrosis and cirrhosis. To address the unmet need for new MASLD biomarkers, we aimed to identify candidate biomarkers using publicly available RNA sequencing (RNA‐seq) and ...
Wenfeng Ma   +17 more
wiley   +1 more source

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