Results 191 to 200 of about 39,545,119 (227)

Staurosporine Targets Mitochondrial Regulator VdAtuA3 to Disrupt Mitochondrial Homeostasis to Control Verticillium Wilt

Plant Biotechnology Journal, Volume 24, Issue 9, Page 5131-5151, September 2026.
ABSTRACT Mitochondria serve as cellular powerhouses that generate ATP via electron transport chain complexes and orchestrate metabolism‐apoptosis cross‐talk, yet genes maintaining mitochondrial homeostasis remain underexplored as antifungal targets. In this study, a previously uncharacterised protein VdAtuA3 was identified as a novel interactor with ...
Ruo‐Cheng Sheng, Huan Li, Jun Wang, Li‐Chao Wang, Hui‐Zi Liu, Xiao‐Feng Dai, Steven J. Klosterman, Jie‐Yin Chen, Krishna V. Subbarao, Feng‐Mao Chen, Dan‐Dan Zhang   +10 more
wiley   +1 more source

Toxicity and DNA Adduct Formation Reinforce AI-Guided Prediction of Aflatoxin B1 Bioactivation in VERO E6 Cells. [PDF]

Toxins (Basel)
Sangwan B, Okoro U, Atteck I, Jaruga P, Ekenna C, Fasullo M.   +5 more
europepmc   +1 more source

Harnessing two UDP‐glycosyltransferases from Saponaria officinalis toward heterologous production of endosomal escape enhancer saponins in Gypsophila elegans hairy roots

The Plant Journal, Volume 127, Issue 6, September 2026.
SUMMARY Soapwort (Saponaria officinalis) synthesizes a vast repertoire of specialized metabolites with bioactive properties. Among those, a specific type of highly glycosylated oleanane‐derived triterpenoid saponins has potential applications in the pharmaceutical industry due to their anticancer activity and enhancement of endosomal escape for ...
Tongtong Qu, Helga Schinkel, Tessa Moses, Kaylan Reddy, René de Vaumas, Stefan Schillberg, Alain Goossens, Elia Lacchini   +7 more
wiley   +1 more source

Hepatic CYP1A2 Activity in Adolescents with and without Obesity Assessed by the Urinary Paraxanthine-to-Caffeine Metabolic Ratio: A Pharmacokinetic Study. [PDF]

J Clin Pharmacol
Gade C, Ullah S, Dalhoff K, Andersen JT, Riis T, Holm JC, Lausten-Thomsen U.   +6 more
europepmc   +1 more source

Estimation of chloroplast macromolecular complex copy numbers and subunit stoichiometries during the Chlamydomonas reinhardtii cell cycle

The Plant Journal, Volume 127, Issue 5, September 2026.
SUMMARY An unbiased, quantitative view of biomolecules in a living cell is a prerequisite for accurate modeling approaches and informs our understanding of cellular metabolism at scale. In this work, we used the total protein approach (TPA), in which the total protein mass of a given proteomics sample is used as a calibrator for absolute protein ...
Stefan Schmollinger, Daniela Strenkert, Samuel O. Purvine, Carrie D. Nicora, Eric Soubeyrand, Gilles J. Basset, Sabeeha S. Merchant   +6 more
wiley   +1 more source

Exogenous application of α-Ionone and Methyl jasmonate induces metabolite-based response in Alstroemeria and reduces feeding damage by Western Flower Thrips. [PDF]

PLoS One
Velasco-Cárdenas AF, Rodríguez D, Coy-Barrera E.   +2 more
europepmc   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 468-484, September 2026.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Enzyme-substrate-inactivator complex formation can impact time-dependent inhibition kinetics. [PDF]

Drug Metab Dispos
Yadav J, Wahlstrom J, Korzekwa K, Nagar S.   +3 more
europepmc   +1 more source

Investigating the Impact of Calcium Channel Blockers on the Pharmacokinetics of Lapatinib: Possible Role of Cytochrome P450 Enzymes and P-glycoprotein Efflux Transporters. [PDF]

Eur J Drug Metab Pharmacokinet
Desai MP, Patil PH, Rajpurohit AUS, Anand VSK, Channabasavaiah JP.   +4 more
europepmc   +1 more source

Liposomal Morin Attenuates DMH-Associated Colonic Oxidative Stress, Inflammation, and Apoptosis/Autophagy-Related Dysregulation in Rats. [PDF]

Pharmaceuticals (Basel)
Akeel MA, Elmorsy EM, Alshammari FM, Shaalan AAM, Aldaghmi AS, Alrashdi BM, Alrashidi SM, Elshopakey GE, Abu Alsel B, Fawzy MS.   +9 more
europepmc   +1 more source