Results 201 to 210 of about 102,281 (237)
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Enzyme, 1982
The rate of oxidative demethylation of ethylmorphine by preparations of microsomes from livers of male rats decreased following whole-body gamma-irradiation, reaching a minimum of 50% of the control value on the 5th or 6th day. The value of apparent Vmax changed markedly after irradiation when the Km value was unaltered. At the same time, the amount of
J M, Zajac, P, Bernard
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The rate of oxidative demethylation of ethylmorphine by preparations of microsomes from livers of male rats decreased following whole-body gamma-irradiation, reaching a minimum of 50% of the control value on the 5th or 6th day. The value of apparent Vmax changed markedly after irradiation when the Km value was unaltered. At the same time, the amount of
J M, Zajac, P, Bernard
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1980
Publisher Summary This chapter focuses on characterization of a reconstituted cytochrome P-450 enzyme system mediating tertiary amine N-oxidation. Evidence is presented for the ability of a reconstituted system containing highly purified cytochrome P-448, NADPH-cytochrome c reductase, and lipid factor to mediate N-oxidation of N,N-dimethylaniline. In
P. Hlavica, S. Hülsmann
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Publisher Summary This chapter focuses on characterization of a reconstituted cytochrome P-450 enzyme system mediating tertiary amine N-oxidation. Evidence is presented for the ability of a reconstituted system containing highly purified cytochrome P-448, NADPH-cytochrome c reductase, and lipid factor to mediate N-oxidation of N,N-dimethylaniline. In
P. Hlavica, S. Hülsmann
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Chemosphere, 1994
Abstract The aim of the present study was to find a suitable wild-rodent to be used as terrestrial bioindicator. The wild mice were trapped at three sites around Vienna and at a fourth location in the countryside. Apodemus flavicollis , the yellow-necked mouse, was the most frequently captured mouse at all four sites.
Amrit Bhatia +4 more
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Abstract The aim of the present study was to find a suitable wild-rodent to be used as terrestrial bioindicator. The wild mice were trapped at three sites around Vienna and at a fourth location in the countryside. Apodemus flavicollis , the yellow-necked mouse, was the most frequently captured mouse at all four sites.
Amrit Bhatia +4 more
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Journal of Inorganic Biochemistry, 1989
Initial reaction rates of oxygen consumption and hydrogen peroxide formation in a cytochrome P-450 catalyzed reaction are practically independent of the nature of tertiary amines that were used as substrates. From the kinetic studies and the substrate conversion results that the amount of water formed in a side reaction is determined by the substrate ...
O, Ristau +3 more
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Initial reaction rates of oxygen consumption and hydrogen peroxide formation in a cytochrome P-450 catalyzed reaction are practically independent of the nature of tertiary amines that were used as substrates. From the kinetic studies and the substrate conversion results that the amount of water formed in a side reaction is determined by the substrate ...
O, Ristau +3 more
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Cancer research, 1983
The metabolism of the suspected carcinogen trichloroethylene (TCE) was studied in in vitro systems involving purified rat liver cytochrome P-450; rat, human, and mouse liver microsomes; rat lung microsomes; and isolated rat and mouse hepatocytes. The studies support the view that metabolism of TCE proceeds through formation of a complex with oxygenated
R E, Miller, F P, Guengerich
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The metabolism of the suspected carcinogen trichloroethylene (TCE) was studied in in vitro systems involving purified rat liver cytochrome P-450; rat, human, and mouse liver microsomes; rat lung microsomes; and isolated rat and mouse hepatocytes. The studies support the view that metabolism of TCE proceeds through formation of a complex with oxygenated
R E, Miller, F P, Guengerich
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Bulletin of Environmental Contamination and Toxicology, 1987
DDT, in very first step of its detoxication is either transformed to DDD by reductive dechlorination (Walker i969; Hassal 1973) or DDE by dehydrochlorination (Datta 1970). For further detoxication, these metabolites undergo a series of reactions which result in the elimination of DDA in urine (Peterson and Robison 1964; Datta 1970; Gold and Brunk 1982).
S S, Zaidi, B D, Banerjee
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DDT, in very first step of its detoxication is either transformed to DDD by reductive dechlorination (Walker i969; Hassal 1973) or DDE by dehydrochlorination (Datta 1970). For further detoxication, these metabolites undergo a series of reactions which result in the elimination of DDA in urine (Peterson and Robison 1964; Datta 1970; Gold and Brunk 1982).
S S, Zaidi, B D, Banerjee
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1979
Stopped flow studies were undertaken to examine the kinetics of reduction of 5,6-benzoflavone-inducible P-450 LM4 by NADPH in the presence of NADPH-cytochrome P-450 reductase and phospholipid under anaerobic CO at 25 degrees C. The reaction exhibited biphasic kinetics irrespective of NADPH concentration or of the molar ratio of reductase to P-450 LM4 ...
K P, Vatsis, D D, Oprian, M J, Coon
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Stopped flow studies were undertaken to examine the kinetics of reduction of 5,6-benzoflavone-inducible P-450 LM4 by NADPH in the presence of NADPH-cytochrome P-450 reductase and phospholipid under anaerobic CO at 25 degrees C. The reaction exhibited biphasic kinetics irrespective of NADPH concentration or of the molar ratio of reductase to P-450 LM4 ...
K P, Vatsis, D D, Oprian, M J, Coon
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Cytochrome P-450 enzyme system inhibitors/tretinoin interaction
Reactions Weekly, 2022openaire +1 more source
Biochemical pharmacology, 1987
The sensitivity of the developing embryo to toxins and drugs is highly dependent on the state of development of the cytochrome P-450 system. Previous work in this laboratory has demonstrated the genotoxicity of aflatoxin B1 (AFB1) to the chicken embryo at 3 days of incubation (DI) and induction of AFB1 genotoxicity by phenobarbital at 7 DI.
N A, Lorr, S E, Bloom
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The sensitivity of the developing embryo to toxins and drugs is highly dependent on the state of development of the cytochrome P-450 system. Previous work in this laboratory has demonstrated the genotoxicity of aflatoxin B1 (AFB1) to the chicken embryo at 3 days of incubation (DI) and induction of AFB1 genotoxicity by phenobarbital at 7 DI.
N A, Lorr, S E, Bloom
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