Results 171 to 180 of about 42,048 (270)

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

In Vitro Pharmacokinetic Properties of MK-2048, a Potent Drug Candidate for HIV Prevention. [PDF]

Viruses
Zheng R, Valicherla GR, Graebing PW, Zhang J, Hillier SL, Rohan LC.   +5 more
europepmc   +1 more source

Biosynthesis and assembly of mitochondrial proteins [PDF]

, 1983
Glaser, Luis, Martin Teintze, Walter Neupert, Elson, Elliot, Teintze, Martin, Neupert, Walter, Frazier, William A.   +6 more
core   +1 more source

Biological and In Silico Evaluation of Novel Methoxyphenol–1,2,3‐Triazole Hybrids as Multifunctional Anti‐Alzheimer's and Anticancer Agents

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Novel methoxyphenol‐1,2,3‐triazole hybrids were synthesized as multifunctional leads. Compound 5e exhibited potent PC3 cytotoxicity (IC50: 3.57 μM), while 5c showed superior AChE inhibition (IC50: 1.44 μM) and high selectivity (SI: 6.22). DFT and docking studies confirmed their dual‐targeting potential, providing a robust scaffold for Alzheimer's and ...
Sultan Onur, Mustafa Çeşme, Ferhan Tümer   +2 more
wiley   +1 more source

Label-Free High-Throughput Screening of CYP3A4 Inhibitors Using Acoustic Ejection Mass Spectrometry. [PDF]

Anal Chem
Rimmer MA, Wang J, Ranathunge TA, Shi Z, Li Y, Lee D, Chai SC, Lin W, Twarog NR, Ansari AZ, Shelat AA, Young BM, Chen T, Yang L.   +13 more
europepmc   +1 more source

The Effect of Efavirenz and Rufinamide on the Pharmacokinetics and Safety of Quizartinib: Two Phase 1 Studies in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Quizartinib is an oral, potent, selective FMS‐like tyrosine kinase 3 (FLT3) inhibitor, approved for the treatment of FLT3‐internal tandem duplication (ITD)–positive acute myeloid leukemia (AML) and under investigation in patients with newly diagnosed FLT3‐ITD–negative AML.
YoungJun Yoo, Hamim Zahir, Shinichi Inaba, Kyoin Koo, Tushar Garimella, Malaz Abutarif, Ming Zheng, Emi Kamiyama, Yuan Xu   +8 more
wiley   +1 more source

Drug-Drug Interactions in Recently Approved Antibacterials: A Mini Review. [PDF]

Eur J Drug Metab Pharmacokinet
Baccari I, Bergmann F, Zeitlinger M.
europepmc   +1 more source

The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3708-3722, June 2026.
ABSTRACT Iridoids constitute a prominent class of plant‐specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate‐specific carboxyl methyltransferases—GjGAMT and CrLAMT—that catalyse the decisive methylation step in ...
Li Li, Zhiteng Luo, Zhaoyin He, Jie Tang, Wuke Wei, Ruoting Zhan, Huihao Zhou, Dongming Ma   +7 more
wiley   +1 more source

Influence of combined CYP2C19 and CYP2D6 phenotypes on adverse drug reactions in patients with major depressive disorder: a clinical cohort study. [PDF]

Pharmacogenomics J
Görnert C, Scherf-Clavel M, Weber H, Roll SC, Eckert A, Reif A, Hahn M.   +6 more
europepmc   +1 more source

Deciphering photosynthetic protein networks: a crosslinking‐MS strategy for studying functional thylakoid membranes

The Plant Journal, Volume 126, Issue 5, June 2026.
SUMMARY Photosynthesis, which sustains life on Earth, depends on organized and yet adaptable protein assemblies embedded in specialized membranes known as thylakoids. Understanding how these complexes interact and reorganize within functional photosynthetic membranes is essential to reveal the molecular basis of energy conversion in cells.
Nicolas Frances, Cecile Giustini, Giovanni Finazzi, Myriam Ferro, Pascal Albanese   +4 more
wiley   +1 more source