Results 11 to 20 of about 39,545,119 (227)

Metabolic pathway of the nitrosoureas catalyzed by cytochrome P-450 and NADPH cytochrome P-450 reductase [PDF]

Three highly purified forms of cytochrome P-450 (P-450a, P-450b, P-450c) from Aroclor 1254-induced rat hepatic microsomes catalyzed the monooxygenation of 1-(2- chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (MeCCNU) and 1-(2-chloroethyl)-3 ...
Potter, David Willard
core   +6 more sources

Integrated assessment of rifampicin-mediated induction of transporters and drug-metabolizing enzymes in a long-term human liver tissue chip system. [PDF]

Clin Pharmacol Ther
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Hartauer ME, Lanphier RM, Ohri S, Snyder J, Tiley JB, Fallon JK, Ho H, Cirit M, Rajan SAP, Brouwer KLR.   +9 more
europepmc   +2 more sources

Role of phospholipid in electron transfer in a reconstituted liver microsomal enzyme system containing cytochrome P-450 [PDF]

, 1971
Phosphatidylcholine, which is required for fatty acid, hydrocarbon and drug hydroxylation in a reconstituted liver microsomal enzyme system, is essential for the enzymatic reduction of cytochrome P-450.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/
Strobel, Henry W., Coon, Minor J., Autor, Anne P.   +2 more
core   +1 more source

Antioxidant Activity of New Aramide Nanoparticles Containing Redox-Active <em>N</em>-phthaloyl Valine Moieties in the Hepatic Cytochrome P₄₅₀ System in Male Rats

Molecules, 2012
We report the synthesis of aramide nanoparticles containing a chiral <em>N</em>-phthaloyl valine moiety and their antioxidant activities on hepatic contents of cytochrome P₄₅₀, amidopyrene <em>N</em> ...
Hammed H. A. M. Hassan, Sabah G. El-Banna, Amel F. Elhusseiny, El-Sayed M. E. Mansour   +3 more
doaj   +1 more source

REPRODUCTIVE PATHOLOGY OF EXPERIMENTALLY INDUCED LEAD POISONING IN RED SOKOTO BUCK: PROTECTIVE EFFECT OF TIGER NUT (CYPERUS ESCULENTUS) [PDF]

Assiut Veterinary Medical Journal, 2020
  Tiger-nut (Cyperus esculentus) is a crop that belongs to family Cyperaceae which produces rhizome and tuber that are small spherical in shape. The tubers have aphrodisiac, carminative, diuretics and several health benefits.
ADAM M., ESIEVO K.A.N., AYO, J.O., ALIYU, A.I., AKANBI O.B., RAJI L.O, BABA A.Y., BISALLA M., SALEH A.   +8 more
doaj   +1 more source

Medicinal importance of grapefruit juice and its interaction with various drugs

Nutrition Journal, 2007
Grapefruit juice is consumed widely in today's health conscious world as a protector against cardiovascular diseases and cancers. It has however, been found to be an inhibitor of the intestinal cytochrome P – 450 3A4 system, which is responsible for the ...
Imam Sardar Z, Kiani Jawad
doaj   +1 more source

Pharmacokinetics of Caffeine: A Systematic Analysis of Reported Data for Application in Metabolic Phenotyping and Liver Function Testing

Frontiers in Pharmacology, 2022
Caffeine is by far the most ubiquitous psychostimulant worldwide found in tea, coffee, cocoa, energy drinks, and many other beverages and food. Caffeine is almost exclusively metabolized in the liver by the cytochrome P-450 enzyme system to the main ...
Jan Grzegorzewski, Florian Bartsch , Adrian Köller, Matthias König   +3 more
doaj   +1 more source

Genetic polymorphism and pharmacokinetics/toxicokinetics of carbamazepine: A general review [PDF]

Vojnosanitetski Pregled
Carbamazepine (CBZ) is a widely used medication in treating epilepsy, bipolar disorder, and neuropathic pain. Its pharmacokinetic profile is highly variable due to slow absorption, extensive metabolism, and auto-induction.
Kovačević Aleksandra, Lukić Vladan, Cikota-Aleksić Bojana, Janković Slobodan M., Dragojević-Simić Viktorija   +4 more
doaj   +1 more source

Side chain hydroxylation of C27-steroids and vitamin D3 by a cytochrome P-450 enzyme system isolated from human liver mitochondria

Journal of Lipid Research, 1981
The present study was undertaken to obtain information on the involvement of cytochrome P-450 in the 26-hydroxylation on bile acid intermediates and in the 25-hydroxylation of vitamin D3 in human liver mitochondria.
H Oftebro, K Saarem, I Björkhem, J I Pedersen   +3 more
doaj   +1 more source

Drug-induced liver toxicity and prevention by herbal antioxidants: an overview

Frontiers in Physiology, 2016
The liver is the center for drug and xenobiotic metabolism, which is influenced most with medication/xenobiotic-mediated toxic activity. Drug-induced hepatotoxicity is common and its actual frequency is hard to determine due to underreporting ...
Divya eSingh, William eCho, Ghanshyam eUpadhyay   +2 more
doaj   +1 more source