Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202 [PDF]
, 2018 CYP17A1 is a key steroidogenic enzyme known to conduct several distinct chemical transformations on multiple substrates. In its hydroxylase activity, this enzyme adds a hydroxyl group at the 17α position of both pregnenolone and progesterone at ...
Bangcharoenpaurpong O. +8 more
core +2 more sources
Substitution of antibodies and receptors with molecularly imprinted polymers in enzyme-linked and fluorescent assays [PDF]
, 2001 A new technique for coating microtitre plates with molecularly imprinted polymers (MIP), specific for low-molecular weight analytes (epinephrine, atrazine) and proteins is presented.
Bossi, Alessandra +5 more
core +1 more source
Drug-induced liver toxicity and prevention by herbal antioxidants: an overview
Frontiers in Physiology, 2016 The liver is the center for drug and xenobiotic metabolism, which is influenced most with medication/xenobiotic-mediated toxic activity. Drug-induced hepatotoxicity is common and its actual frequency is hard to determine due to underreporting ...
Divya eSingh +2 more
doaj +1 more source
Cellular development associated with induced mycotoxin synthesis in the filamentous fungus Fusarium graminearum. [PDF]
PLoS ONE, 2013 Several species of the filamentous fungus Fusarium colonize plants and produce toxic small molecules that contaminate agricultural products, rendering them unsuitable for consumption. Among the most destructive of these species is F.
Jon Menke +3 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
The Use of Isomeric Testosterone Dimers to Explore Allosteric Effects in Substrate Binding to Cytochrome P450 CYP3A4 [PDF]
, 2016 : Cytochrome P450 CYP3A4 is the main drug-metabolizing enzyme in the human liver, being responsible for oxidation of 50% of all pharmaceuticals metabolized by human P450 enzymes.
Bastien, Dominic +6 more
core +2 more sources
Adrenal mitochondria and steroidogenesis: from individual proteins to functional protein assemblies
Frontiers in Endocrinology, 2016 The adrenal cortex is critical for physiological function as the central site of glucocorticoid and mineralocorticoid synthesis. It possesses a great degree of specialized compartmentalization at multiple hierarchical levels, ranging from the tissue down
Andrew Midzak, Vassilios Papadopoulos
doaj +1 more source
: pharmacogenetics; drug toxicity; cytochrome P-450 enzyme system; TPMT; genetic testing
Paediatria Croatica, 2013 Varijabilnosti u učinku lijeka mogu se djelomično objasniti genetičkim razlikama. Postoje interindividualne razlike u metaboličkom itransportnom kapacitetu i detoksikaciji lijekova i drugih ksenobiotika. Osjetljivost na toksične učinke jednim dijelom ovisi ogenetičkom polimorfi zmu metaboličkih enzima faze I. i faze II.
Nada Božina, Lana Pejnović
openaire +1 more source
Resonance Raman Spectroscopy Reveals that Substrate Structure Selectively Impacts the Heme-Bound Diatomic Ligands of CYP17 [PDF]
, 2013 An important function of steroidogenic cytochromes P450 is the transformation of cholesterol to produce androgens, estrogens, and the corticosteroids.
Gregory, Michael C. +3 more
core +2 more sources
Therapeutic drug monitoring of tacrolimus in kidney transplantation
Indian Journal of Transplantation, 2020 Calcineurin inhibitors (CNI) are the backbone of present-day immunosuppressive regimen in kidney transplant recipients. Tacrolimus (TAC) has gradually replaced cyclosporine as CNI of choice due to its better potency and side effect profile.
Shyam Bihari Bansal
doaj +1 more source