Results 21 to 30 of about 42,048 (270)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Cellular development associated with induced mycotoxin synthesis in the filamentous fungus Fusarium graminearum. [PDF]

PLoS ONE, 2013
Several species of the filamentous fungus Fusarium colonize plants and produce toxic small molecules that contaminate agricultural products, rendering them unsuitable for consumption. Among the most destructive of these species is F.
Jon Menke, Jakob Weber, Karen Broz, H Corby Kistler   +3 more
doaj   +1 more source

Alcohol metabolism and toxicity: Role of cytochrome P-450 [PDF]

, 1984
A new isozyme of cytochrome P-450, designated form 3a on the basis of its relative electrophoretic mobility, has been purified to homogeneity from liver microsomes of rabbits treated chronically with ethanol.
Koop, Dennis R., Reeve, Lorraine E., Coon, Minor J., Crump, Becky L.   +3 more
core   +1 more source

Adrenal mitochondria and steroidogenesis: from individual proteins to functional protein assemblies

Frontiers in Endocrinology, 2016
The adrenal cortex is critical for physiological function as the central site of glucocorticoid and mineralocorticoid synthesis. It possesses a great degree of specialized compartmentalization at multiple hierarchical levels, ranging from the tissue down
Andrew Midzak, Vassilios Papadopoulos
doaj   +1 more source

Therapeutic drug monitoring of tacrolimus in kidney transplantation

Indian Journal of Transplantation, 2020
Calcineurin inhibitors (CNI) are the backbone of present-day immunosuppressive regimen in kidney transplant recipients. Tacrolimus (TAC) has gradually replaced cyclosporine as CNI of choice due to its better potency and side effect profile.
Shyam Bihari Bansal
doaj   +1 more source

Enzyme Activity of the Cytochrome P-450 Monooxygenase System in the Presence of Single Chain Lipid Molecules

Zeitschrift für Naturforschung C, 2001
Abstract The influence of single chain lipids on the 7-ethoxycoumarin O-deethyase activity of the reconstituted binary protein complex of isolated cytochrome P450 and NADPH-cytochrome P450 reductase has been examined. The enzyme activity of this binary enzyme complex has been shown to be influenced by (i) altering the complexation ...
D, Müller-Enoch, R, Fintelmann, A, Nicolaev, H, Gruler   +3 more
openaire   +2 more sources

Polymethoxylated flavonoids in citrus fruits: absorption, metabolism, and anticancer mechanisms against breast cancer [PDF]

PeerJ
Polymethoxylated flavonoids (PMFs) are a subclass of flavonoids found in citrus fruits that have shown multifunctional biological activities and potential anticancer effects against breast cancer.
Yiyu Wang, Yuan Mou, Senlin Lu, Yuhua Xia, Bo Cheng   +4 more
doaj   +2 more sources

Induction of Microsomal Liver Enzymes by Silymarin in Experimental Animals

مجلة كلية الطب, 2011
Background: previous researches showed that the hepatoprotective effect of silymarin was through inhibition of cytochrome p450- system (e.g. protection against Amanita toxin), in addition to protection from free radicals generated by this enzymatic ...
Bahir A.R. Mshiemish, Saad A. R. Hussain, Amaal A. Suliman   +2 more
doaj   +1 more source

Evaluation of pharmacokinetic and pharmacodynamic interaction between repaglinide and atazanavir in healthy, diabetic and hepatic impaired rats: possible inhibition of CYP3A, OATP, and P-glycoprotein transporters

ADMET and DMPK, 2016
The metabolic syndrome in HIV infected patients is particularly associated with the use protease inhibitors. Atazanavir is an inhibitor of the cytochrome P 450 (CYP) system, in particular CYP3A4 and CYP2C9 which can affect the metabolism of several drugs.
Thirumal Eswara Goud, Srinivas Maddi, Nayakanti Devanna, Thatipamula Rajendra Prasad   +3 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source