Results 171 to 180 of about 127,252 (263)

From closed to open: three dynamic states of membrane-bound cytochrome P450 3A4. [PDF]

J Comput Aided Mol Des
Spanke VA, Egger-Hoerschinger VJ, Ruzsanyi V, Liedl KR.   +3 more
europepmc   +1 more source

Unveiling a Novel Zearalenone Biodegradation Pathway in <i>Metarhizium anisopliae</i> and Elucidating the Role of Cytochrome P450. [PDF]

Int J Mol Sci
Nowak M, Kozłowska E, Agier J, Góralczyk-Bińkowska A, Różalska S.   +4 more
europepmc   +1 more source

Pharmacokinetics of Ethyl Glucuronide and Ethyl Sulfate and Pharmacodynamic Effects Following Intravenous and Oral Administration of Ethanol to Exercised Horses

Drug Testing and Analysis, EarlyView.
This study describes the pharmacokinetics of ethanol metabolites following intravenous and oral administration to horses. Based on rapid metabolism, ethyl glucuronide is the best candidate for monitoring of illicit administration to performance horses.
Heather K. Knych, Jeff Blea, Mary Scollay, Philip H. Kass, Daniel S. McKemie   +4 more
wiley   +1 more source

Thylakoid Targeting Improves Stability of a Cytochrome P450 in the Cyanobacterium <i>Synechocystis</i> sp. PCC 6803. [PDF]

ACS Synth Biol
Hanamghar SS, Mellor SB, Mikkelsen L, Crocoll C, Motawie MS, Russo DA, Jensen PE, Zedler JAZ.   +7 more
europepmc   +1 more source

Total Synthesis of Ectocarpin A

European Journal of Organic Chemistry, Accepted Article.
A total enantioselective synthesis of Ectocarpin A, an oxylipin identified through the first hydroperoxide bicyclase activity of CYP5164A3 in brown algae, has been successfully completed in 12 steps starting from tetrahydro‐1H‐cyclopentafuranone.
Alexandre Guy, Thierry Durand, Camille Oger   +2 more
wiley   +1 more source

Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes. [PDF]

Front Pharmacol
Faramarzi S, Bassan A, Cross KP, Yang X, Myatt GJ, Volpe DA, Stavitskaya L.   +6 more
europepmc   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

An Enhanced Metabolization Protocol for In Vitro Genotoxicity Assessment of N‐Nitrosamines in Mammalian Cells

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT N‐Nitrosamines (NAs) are probable human carcinogens and were detected as impurities in pharmaceuticals, which led to a concern for human health. NAs require metabolic activation before they become mutagenic, and not all NAs are mutagenic since their reactivity is related to their structure.
M. E. Geijer, A. M. Gernaat, N. Moelijker, I. Brandsma, G. Hendriks   +4 more
wiley   +1 more source

Computational Insights into the Antioxidant Activity of Luteolin: Density Functional Theory Analysis and Docking in Cytochrome P450 17A1. [PDF]

Pharmaceuticals (Basel)
de Aguiar ASN, de Carvalho LBR, Gomes CM, Castro MM, Martins FS, Borges LL.   +5 more
europepmc   +1 more source

Cytochrome P450 2C19 Genotypes and Clopidogrel in Patients With Ischemic Stroke: A Nonrandomized Clinical Trial.

JAMA Netw Open
Jung YH, Song TJ, Kim J, Park HK, Han SW, Kim YD, Park JH, Cha JK, Park HY, Sohn SI, Yu S, Lee JH, Shin DH, Kim EG, Lee HS, Lee KY, PLATELET Trial Investigators.   +16 more
europepmc   +1 more source