Results 181 to 190 of about 127,252 (263)

Interim analysis of the long‐term efficacy and safety of azetukalner in an ongoing open‐label extension study following a phase 2b clinical trial (X‐TOLE) in adults with focal epilepsy

Epilepsia Open, EarlyView.
Abstract Objective To report interim data from an ongoing, open‐label extension (OLE) of a Phase 2b study (X‐TOLE) of azetukalner in adults with focal onset seizures (FOS) receiving 1–3 antiseizure medications. Methods Eligible participants enrolled in the 7‐year OLE at 20 mg azetukalner once daily with food.
Jacqueline A. French, Roger J. Porter, Emilio Perucca, Martin J. Brodie, Michael A. Rogawski, Cynthia Harden, Jenny Qian, Constanza Luzon Rosenblut, Christopher Kenney, Gregory N. Beatch, X‐TOLE Study Group, Bassel Abou‐Khalil, Sami Aboumatar, Robert Armstrong, Ricardo Ayala, Juan Luis Becerra, Francesca Bisulli, Victor Biton, Christian Brandt, Dulce Campos, Laura Canafoglia, Micaela Chatman, Samuel Destefano, Carlo Di Bonaventura, Toufic Fakhoury, Evan Fertig, Nathan Fountain, Antonio Gambardella, Michael Gelfand, Antonio Gil‐Nagel, Khalid Hamandi, Heidi Henninger, Shahram Izadyar, Sergii Kharchuk, Pavel Klein, Kenneth Laxer, Rebekka Lehmann, Holger Lerche, Andrew Lerman, George Li, Kore Liow, Irene Garcia Morales, Dean Naritoku, Alberto Pinzon‐Ardila, Chiara Pizzanelli, Rodrigo Rocamora, Juan Rodriguez‐Uranga, Joanne Rogin, Felix Rosenow, Ahmed Sadek, Rosa Ana Saiz‐Diaz, Juan Carlos Sanchez, Andreas Schulze‐Bonhage, Pedro Serrano‐Castro, Jose Serratosa, Michael Sperling, Claude Steriade, William Tatum, Christian Tilz, Rafael Toledano, Manuel Toledo, Vicente Villanueva, David Vossler   +62 more
wiley   +1 more source

Evaluation of pharmacogenomic testing to identify cytochrome P450 and SLCO1B1 enzymes and adverse drug events: A non-experimental observational research. [PDF]

Medicine (Baltimore)
Flowers-Moore T, Rapp AR, Salazar JH, Rajendran R.   +3 more
europepmc   +1 more source

Effects of perampanel on bone health in adult patients with epilepsy

Epilepsia Open, EarlyView.
Abstract Objective The objective was to assess the effects of perampanel (PER) on bone metabolism and bone mineral density (BMD) in adult patients with epilepsy. Methods This retrospective study included consecutive patients admitted to the Epilepsy Center of Sichuan Provincial People's Hospital from January 2023 to June 2024.
Mingxing Yu, Nana Zhang, Chunyan Chen, Yuxuan He, Jing Meng, Wen Luo, Yi Liang, Yi Guo, Liang Yu   +8 more
wiley   +1 more source

Cytochrome P450 3A gene family and medication in childhood nephrotic syndrome: An update. [PDF]

Glob Med Genet
Kochuthakidiyel Suresh P, Venkatachalapathy Y, Ekambaram S, Sangeetha, Manoj M, C D M.   +5 more
europepmc   +1 more source

Heme Regulatory Motif of Heme Oxygenase-2 Is Involved in the Interaction with NADPH-Cytochrome P450 Reductase and Regulates Enzymatic Activity. [PDF]

Int J Mol Sci
Sugishima M, Kusumoto T, Sato H, Sakamoto H, Higashimoto Y, Yamamoto K, Taira J.   +6 more
europepmc   +1 more source

Naturally occurring variation in a cytochrome P450 modifies thiabendazole responses independently of beta-tubulin. [PDF]

PLoS Pathog
Collins JB, Dilks CM, Hahnel SR, Rodriguez B, Fox BW, Redman E, Yu J, Cooke B, Sihuta K, Zamanian M, Roy PJ, Schroeder FC, Gilleard JS, Andersen EC.   +13 more
europepmc   +1 more source

Comparing Transcriptomic Responses to Chemicals Across Six Species Using the EcoToxChip RNASeq Database

Environmental Toxicology and Chemistry, EarlyView.
Abstract The EcoToxChip project includes RNA‐sequencing data from experiments involving model (Japanese quail, fathead minnow, African clawed frog) and ecological (double‐crested cormorant, rainbow trout, northern leopard frog) species at multiple life stages (whole embryo and adult) exposed to eight chemicals of environmental concern known to perturb ...
Krittika Mittal, Jessica Ewald, Doug Crump, Jessica Head, Markus Hecker, Natacha Hogan, Jianguo Xia, Niladri Basu   +7 more
wiley   +1 more source

Rice Cytochrome P450 Protein CYP71P1 Is Required for Heat Stress Tolerance by Regulating Serotonin Biosynthesis and ROS Homeostasis. [PDF]

Plants (Basel)
Lv X, Zhao X, Wang F, Wang H, Zhang Y, Ruan B, Dong G, Yu Y, Wu L, Chen F.   +9 more
europepmc   +1 more source

Organ‐on‐Chip: The Future of Nutrition Research in a One Health World

Food Frontiers, EarlyView.
Organ‐on‐chips offer a promising tool for evaluating food and feed safety. Organ‐on‐chips also present a scientifically robust and ethical alternative to animal studies. ABSTRACT The One Health approach emphasizes the interconnectedness of human, animal, and environmental health, recognizing that the health of each is interdependent and influenced by ...
Manuela Cassotta, Maria Elexpuru‐Zabaleta, Sandra Sumalla Cano, Yasmany Armas Diaz, Francesca Giampieri, Zou Xiaobo, Di Zhang, Giuseppe Grosso, Maurizio Battino   +8 more
wiley   +1 more source

Development of a high throughput cytochrome P450 ligand-binding assay. [PDF]

J Biol Chem
Frydendall EK, Scott EE.
europepmc   +1 more source