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Pharmacogenetics of the Cytochromes P450
Current Topics in Medicinal Chemistry, 2004The cytochromes P450 are a family of heme-containing proteins with a major role in the oxidation of both xenobiotics (including prescribed drugs) and endogenous compounds. There are at least 57 human P450s (termed isoforms) which are all encoded by separate genes but only 10 of these contribute to drug metabolism, with the major contribution coming ...
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Induction of Cytochrome P450s by Rutaecarpine and Metabolism of Rutaecarpine by Cytochrome P450s
Planta Medica, 2004Rutaecarpine is an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa. Recently, rutaecarpine has been characterized to have an anti-inflammatory activity through cyclooxygenase-2 inhibition. In the present studies, the effects of rutaecarpine on liver cytochrome P450 s (P450s) and P450 s involved in the metabolism of rutaecarpine ...
Sang Kyu, Lee +8 more
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Current Drug Metabolism, 2001
Humans and rodents are exposed to many foreign compounds in their diet (e.g., herbal supplements such as St. John's wart), in their environment (e.g., organochlorine pesticides and polychorinated biphenyls), and as clinically prescribed drugs (e.g., rifampin and phenobarbital).
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Humans and rodents are exposed to many foreign compounds in their diet (e.g., herbal supplements such as St. John's wart), in their environment (e.g., organochlorine pesticides and polychorinated biphenyls), and as clinically prescribed drugs (e.g., rifampin and phenobarbital).
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Current Topics in Medicinal Chemistry, 2004
The induction of cytochromes P450 (CYPs) has been appreciated for some time but an understanding of the mechanisms involved has been poorly understood until recently. The discovery of the role of nuclear receptors such as the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) has provided a major trigger for research in this area.
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The induction of cytochromes P450 (CYPs) has been appreciated for some time but an understanding of the mechanisms involved has been poorly understood until recently. The discovery of the role of nuclear receptors such as the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) has provided a major trigger for research in this area.
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Structure and Chemistry of Cytochrome P450
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Denisov, I. +3 more
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Engineering Cytochrome P450 Enzymes
Chemical Research in Toxicology, 2007The last 20 years have seen the widespread and routine application of methods in molecular biology such as molecular cloning, recombinant protein expression, and the polymerase chain reaction. This has had implications not only for the study of toxicological mechanisms but also for the exploitation of enzymes involved in xenobiotic clearance.
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2008
PART A: Chapter 1: Cytochrome P450 Structure and Function: An Evolutionary Perspective Chapter 2: Generation of reactive intermediates by cytochromes P450 PART B: Chapter 3: The CYP1A subfamily Chapter 4: The CYP1B subfamily Chapter 5: The CYP2A subfamily Chapter 6: The CYP2B subfamily Chapter 7: The CYP2C subfamily Chapter 8: The CYP2D subfamily ...
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PART A: Chapter 1: Cytochrome P450 Structure and Function: An Evolutionary Perspective Chapter 2: Generation of reactive intermediates by cytochromes P450 PART B: Chapter 3: The CYP1A subfamily Chapter 4: The CYP1B subfamily Chapter 5: The CYP2A subfamily Chapter 6: The CYP2B subfamily Chapter 7: The CYP2C subfamily Chapter 8: The CYP2D subfamily ...
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Journal of Lipid Mediators and Cell Signalling, 1995
M L, Schwartzman, J C, McGiff
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M L, Schwartzman, J C, McGiff
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