Results 1 to 10 of about 23,312 (291)
Metabolic profiling and transcriptome analysis of Sinomenium acutum provide insights into the biosynthesis of structurally diverse benzylisoquinoline alkaloids [PDF]
Scientific ReportsSinomenium acutum, a traditional medicinal plant, has been utilized for millennia to alleviate various forms of rheumatic pain symptoms. The structurally diverse benzylisoquinoline alkaloids (BIAs) found in S.
Xiuyu Liu +6 more
doaj +2 more sources
Nitroreduction of flutamide by Cunninghamella elegans NADPH: Cytochrome P450 reductase
Biochemistry and Biophysics Reports, 2022 The microbial model of mammalian drug metabolism, Cunninghamella elegans, has three cytochrome P450 reductase genes in its genome: g1631 (CPR_A), g4301 (CPR_B), and g7609 (CPR_C).
Mohd Faheem Khan, Cormac D. Murphy
doaj +1 more source
Drug interaction of boceprevir and amlodipine in a patient with hepatitis C: A cardiovascular follow-up [PDF]
Journal of Microbiology and Infectious Diseases, 2015 Boceprevir is a NS3/4A hepatitis C virus (HCV) protease inhibitor, used in combination with peginterferon and ribavirin to treat HCV. Boceprevir undergoes extensive metabolism via cytochrome P450-mediated oxidation and ketoreduction by cytosolic aldo ...
Çiğdem Kader +3 more
doaj +1 more source
Frontiers in Chemistry, 2023 Cytochromes bd are essential for microaerobic respiration of many prokaryotes including a number of human pathogens. These enzymes catalyze the reduction of molecular oxygen to water using quinols as electron donors.
Tamara N. Grund +9 more
doaj +1 more source
PLoS ONE, 2023 Cytochrome b561 (cytb561) proteins comprise a family of transmembrane oxidoreductases that transfer single electrons across a membrane. Most eukaryotic species, including insects, possess multiple cytb561 homologs. To learn more about this protein family
Jessica D Holst +3 more
doaj +3 more sources
Engineering Microbiology, 2022 Cytochrome P450 (CYP) enzymes play crucial roles during the evolution and diversification of ancestral monocellular eukaryotes into multicellular eukaryotic organisms due to their essential functionalities including catalysis of housekeeping biochemical ...
Pradeepraj Durairaj, Shengying Li
doaj +1 more source
Methemoglobin Reductase (Cytochrome b5 Reductase) Deficiency in Congenital Methemoglobinemia [PDF]
Blood, 1974 Abstract Two NADH diaphorases, diaphorase I and II, were isolated from normal red cells and congenital methemoglobinemic red cells by CM-cellulose and DE 32 column chromatography. For methemoglobinemic sample, activities of diaphorase I and diaphorase II were 80% and less than 5% of those for the normal red cells, respectively.
T, Kitao +3 more
openaire +2 more sources
Molecules, 2023 Diterpenoid alkaloids (DAs) are major pharmacologically active ingredients of Aconitum vilmorinianum, an important medicinal plant. Cytochrome P450 monooxygenases (P450s) are involved in the DA biosynthetic pathway, and the electron transfer reaction of ...
Jingping Cheng +6 more
doaj +1 more source
Exploring ND-011992, a quinazoline-type inhibitor targeting quinone reductases and quinol oxidases
Scientific Reports, 2023 Bacterial energy metabolism has become a promising target for next-generation tuberculosis chemotherapy. One strategy to hamper ATP production is to inhibit the respiratory oxidases.
Jan Kägi +5 more
doaj +1 more source
Resolution of Key Roles for the Distal Pocket Histidine in Cytochrome c Nitrite Reductases [PDF]
, 2015 Cytochrome c nitrite reductases perform a key step in the biogeochemical N-cycle by catalyzing the six-electron reduction of nitrite to ammonium. These multi-heme cytochromes contain a number of His/His ligated c-hemes for electron transfer and a ...
Burlat, Benedicte +7 more
core +5 more sources