Results 31 to 40 of about 160,314 (244)

Membrane bound cytochrome p-450 determines the optimal temperatures of NADPH - cytochrome p-450 reductase and cytochrome p-450-linked monooxygenase reactions in rat and trout hepatic microsomes

, 1985
The hepatic monooxygenase systems largely responsible for the biotransformation of drugs and other xenobiotics are comprised of NADPH-cytochrome P-450 reductase and multiple forms of cytochrome P-450.
Mannering, Gilbert J, Prema , Gurumurthy
core   +1 more source

Comparison of highly purified sheep liver and lung nadph-cytochrome P-450 reductases by the analysis of kinetic and catalytic properties

, 1988
1. Reductase was purified to electrophoretic homogeneity from sheep liver and lung microsomes. The specific activity of both enzymes ranged from 55 to 66 μ mol cytochrome c reduced/min/mg protein. 2.
Arınç, Emel, İşcan, Mesude Y., ARINC, E, ISCAN, MY   +3 more
core   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

SERR spectroelectrochemical study of cytochrome cd1 nitrite reductase co-immobilized with physiological redox partner cytochrome c552 on biocompatible metal electrodes [PDF]

, 2015
© 2015 Silveira et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Peter Hildebrandt (373077), Smilja Todorovic, Célia M Silveira, Moura, Isabel, Isabel Moura (757629), Quintas, Pedro O., M Gabriela Almeida, Pedro O. Quintas (757628), José J. G. Moura (503784), Todorovic, Smilja, Peter Hildebrandt, Silveira, Célia M., Pedro O. Quintas, Hildebrandt, Peter, Pedro O Quintas, M. Gabriela Almeida (757630), José J G Moura, Almeida, M. Gabriela, Célia M. Silveira (757627), Moura, José J. G., Isabel Moura, Smilja Todorovic (165616), M. Gabriela Almeida, Célia M. Silveira, José J. G. Moura, Hildebrandt Peter, Almeida M. Gabriela, Todorovic Smilja, Moura Isabel, Moura José J. G., Quintas Pedro O., Silveira Célia M.   +31 more
core   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Independent elaboration of steroid hormone signaling pathways in Metazoans [PDF]

, 2009
Steroid hormones regulate many physiological processes in vertebrates, nematodes and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors.
Laudet, Vincent, Vincent Laudet, Baker, Michael E., Chantal Dauphin-Villemant, Demeneix, Barbara A., Markov, Gabriel, V, Gabriel V. Markov, Demeneix, Ba, Tavares, Raquel, Michael E. Baker, Markov, Gv., Raquel Tavares, Barbara A. Demeneix, Dauphin-Villemante, C., Laudet, V., Dauphin-Villemant, Chantal, Tavares, R., Bakerf, Me.   +17 more
core   +1 more source

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

Photoenzymatic Synthesis of Tertiary Amines by Engineered Flavin-Dependent Ene-Reductases

, 2021
α-Tertiary amines are a common motif in pharmaceutically important molecules but are challenging to prepare using asymmetric catalysis. Here, we demonstrate engineered flavin-dependent ‘ene’-reductases (EREDs) can catalyze radical additions into oximes ...
Todd K. Hyster, Todd K. Hyster (1323081), Joshua R. Turek-Herman (11715407), Young Joo Choi (1561144), Ryan D. Cohen (1458091), Xin Gao (14001), Ryan D. Cohen, Xin Gao, Joshua R. Turek-Herman, Young Joo Choi   +9 more
core   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources