Results 51 to 60 of about 160,314 (244)
Chemistry – A European Journal, EarlyView.Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi +6 more
wiley +1 more source
Biocatalytic Enantioselective Reduction of Cyclopropenyl Esters and Ketones Using Ene-Reductases
Enantioselective reduction of cyclopropenyl esters and ketones to optically active cyclopropanes has been achieved by using whole-cell-overexpressing ene-reductases (EREDs). By using these enzymes, trans-cyclopropanes were isolated in good yield and high
Tomohiro Yasukawa (1595212) +4 more
core +1 more source
Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases.
, 2003 Iron has a variety of functions in cellular organisms ranging from electron transport and DNA synthesis to adenosine triphosphate (ATP) and neurotransmitter synthesis.
Vargas, J D +7 more
core +1 more source
Trends and Future Directions in Organic Chemistry for Drug Discovery
Chemistry – A European Journal, EarlyView.Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley +1 more source
The preparation and characterisation of novel microperoxidase biocatalysts [PDF]
, 1987 Microperoxidases are haem oligopeptides, derived from the proteolytic digestion of cytochrome c, possessing peroxidase activity. They are termed "microperoxidases" in contrast to other relatively large peroxidases such as horseradish peroxidase.
Atkinson, Susan Lesley
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Clinical Pharmacology &Therapeutics, EarlyView.The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhuolin Zhang +5 more
wiley +1 more source
Functional Domains of Assimilatory Nitrate Reductases and Nitrite Reductases
, 1990 Biochemical investigation of nitrate assimilation enzymes spans the past four decades. With the molecular cloning of genes for nitrate reductases and nitrite reductases, exciting new prospects are developing for the study of these enzymes.
Kinghorn, James R., Campbell, Wilbur H.
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Clinical Pharmacology &Therapeutics, EarlyView.Chronic inflammation has long been known to downregulate the activity of certain cytochrome P450 (CYP) enzymes—the main enzymes responsible for the phase I metabolism of many small molecule drugs—potentially leading to higher exposures in patients with chronic inflammatory diseases compared to healthy volunteers. Neglecting this potential difference in
Johannes Tillil +6 more
wiley +1 more source
The effect of anti‐seizure medications on exposure to statins: A systematic review and meta‐analysis
Epileptic Disorders, EarlyView.Abstract Objectives Antiseizure medications (ASMs) can reduce the efficacy of statin treatment, partly due to reduction in statin concentrations. In this systematic review and network meta‐analysis (NMA), we compared the effects of ASMs and the prototypical enzyme inducer rifampin on statin exposure.
Sharon Valiyev Huino +5 more
wiley +1 more source
, 1998 The effects of the neuroleptic flupenthixol on the expression of the genes coding for the mitochondrial ubiquinone and cytochrome b5 reductases have been studied because of the importance of these enzymes in energy metabolism, oxidative stress and also ...
WHATLEY SA +6 more
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