Results 111 to 120 of about 101,816 (333)
Screening of flavonoid aglycons’ metabolism mediated by the human liver cytochromes P450
Acta Pharmaceutica, 2019 Biological effects of flavonoids have been extensively studied in the last 80 years. As flavonoids represent a rather large group of compounds, data on metabolic biotransformations of these compounds is relatively limited to those well studied.
Benković Goran +3 more
doaj +1 more source
Yeast lactic dehydrogenase and cytochrome b2 [PDF]
, 1946 S. J. Bach, Martin Dixon, L. G. Zerfas
openalex +1 more source
Engineered Hydrogels for Organoid Models of Human Nonalcoholic Fatty Liver Disease
Advanced Science, Volume 12, Issue 22, June 12, 2025.Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation and extracellular matrix stiffening. An in vitro NAFLD model is developed using engineered hydrogels (G′ ≈ 1–6 kPa) and iPSC‐derived hepatic organoids. It is demonstrated that higher stiffness can increase lipid droplet accumulation, fibrosis, and metabolic dysregulation ...
Yueming Liu +11 more
wiley +1 more source
Scientific ReportsC-type cytochromes fulfil many essential roles in both aerobic and anaerobic respiration. Their characterization requires large quantities of protein which can be obtained through heterologous production.
Helena Fuchs +2 more
doaj +1 more source
Prediction of Cytochrome P450-Mediated Metabolism Using a Combination of QSAR Derived Reactivity and Induced Fit Docking [PDF]
arXiv, 2018 Prediction of metabolism in cytochrome P450s remains to be a crucial yet challenging topic in discovering and designing drugs, agrochemicals and nutritional supplements. The problem is challenging because the rate of P450 metabolism depends upon both the intrinsic chemical reactivity of the site and the protein-ligand geometry that is energetically ...
arxiv
Advanced Science, Volume 12, Issue 22, June 12, 2025.Here a transcranial photo‐biomodulation approach is developed using near‐infrared (NIR) laser on hippocampus of mice, revealing significant improvements in learning and memory ability of mice under normal and disease conditions. The improvement results from the high‐density cell‐induced NIR local energy deposition, neuronal activation, and axonogenesis
Wei‐Tong Pan +6 more
wiley +1 more source
CYTOCHROME COMPONENTS IN THE SPADIX OF ARUM MACULATUM [PDF]
, 1956 Derek S. Bendall, Robert D. Hill
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Advanced Science, EarlyView.LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang +5 more
wiley +1 more source
Structure-Based Drug Design for Cytochrome P450 Family 1 Inhibitors
Bioinorganic Chemistry and Applications, 2018 Cytochromes P450 are a class of metalloproteins which are responsible for electron transfer in a wide spectrum of reactions including metabolic biotransformation of endogenous and exogenous substrates.
Zbigniew Dutkiewicz, Renata Mikstacka
doaj +1 more source