Results 251 to 260 of about 312,948 (355)

Low magnetic fields stimulate cardiac mitochondrial bioenergetics with a bell-shaped response: Possibly via a radical pair mechanism. [PDF]

Comput Struct Biotechnol J
Beutner G, Yuh HJ, Goldenberg I, Wallace DC, Porter GA, Moss AJ, Sheu SS.   +6 more
europepmc   +1 more source

The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The quantitative effect of several inhibitory drugs on the development of adverse drug reactions (ADRs) is currently difficult to estimate. Our aim was to identify metabolic pathways, which, when inhibited, increase the risk for certain ADRs, and to use this system to consider comedication at individual level. Methods Data of a prospective
Judith Berres, Justyna Wozniak, Hannah Fölsch, Anja Knueppel‐Ruppert, Verena Graeff, Andrea Kriegisch‐Stumpf, Harald Dormann, Julia C. Stingl, Katja S. Just   +8 more
wiley   +1 more source

Current understanding of electroautotrophy and its relevance in astrobiology-related research. [PDF]

mLife
Wang Q, Lau Vetter MCY.
europepmc   +1 more source

Pharmacokinetics and pharmacodynamics of intravenous and oral (S)‐ketamine: Investigating metabolite contribution to subjective effects

British Journal of Clinical Pharmacology, EarlyView.
Aims Oral administration of (S)‐ketamine for treatment‐resistant depression (TRD), as alternative to the registered intranasal or off‐label intravenous administrations, has high potential. However, it is characterized by an extensive first‐pass metabolism, resulting in low (S)‐ketamine exposure and high levels of active metabolites, including (S ...
Marije E. Otto, Gabriël E. Jacobs, Joost C. van Mechelen, Laura G. J. M. Borghans, Johan G. C. van Hasselt, Linda B. S. Aulin   +5 more
wiley   +1 more source

Study of Brain Cells in Neurodegenerative Diseases: Raman Microspectroscopy and Scanning Ion-Conductance Microscopy. [PDF]

Sovrem Tekhnologii Med
Morozova KI, Parshina EY, Kazakova TA, Yusipovich AI, Slatinskaya OV, Brazhe AR, Grivennikov IA, Brazhe NA, Maksimov GV.   +8 more
europepmc   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

Flavin Biosynthesis Enhances Extracellular Electron Transfer in Bioengineered Escherichia coli. [PDF]

Adv Sci (Weinh)
Mouhib M, Reggente M, Wang H, Roullier C, Boghossian AA.   +4 more
europepmc   +1 more source

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

British Journal of Clinical Pharmacology, EarlyView.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup, Michel Tod, Laurent Bourguignon   +2 more
wiley   +1 more source

Erratum: "Dysregulation of lipid mediators in patients with frequent exacerbations of COPD" Marie Fisk, Esteban A. Gomez, Yuan Sun, Monika Mickute, Carmel McEniery, John R. Cockcroft, Charlotte Bolton, Jonathan Fuld, Joseph Cheriyan, Yasmin, William MacNee, Ruth Tal-Singer, Michael Polkey, Ian Wilkinson and Jesmond Dalli. <i>ERJ Open Res</i> 2025; 11: 00950-2023. [PDF]

ERJ Open Res
europepmc   +1 more source

New insights in uranium bioremediation by cytochromes of the bacterium Geotalea uraniireducens. [PDF]

J Biol Chem
Almeida A, Turner DL, Silva MA, Salgueiro CA.   +3 more
europepmc   +1 more source